Homozygous α-thalassemia in a growth retarded, non-hydropic premature newborn

Journal of Perinatology

Volumn 28, Issue 2, 2008, Pages 158-159

  Ng, Y P M ^a   Joseph, R ^a,b   Biswas, A ^a,b  

^a NATIONAL UNIVERSITY HOSPITAL   (Singapore)

^b NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTIC AGENT; BICARBONATE; HEMOGLOBIN F; HEMOGLOBIN H; INOTROPIC AGENT; MAGNESIUM SULFATE; PLASMA SUBSTITUTE;

ALPHA THALASSEMIA; ANEMIA; ARTICLE; ARTIFICIAL VENTILATION; BLOOD CYTOLOGY; CARDIOPULMONARY INSUFFICIENCY; CASE REPORT; CLINICAL FEATURE; CRYPTORCHISM; DISSEMINATED INTRAVASCULAR CLOTTING; ERYTHROCYTE CONCENTRATE; EXCHANGE BLOOD TRANSFUSION; FEMALE; FETUS OUTCOME; GENETIC RISK; HEMOGLOBINOPATHY; HEPATOMEGALY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HYPOSPADIAS; INTRAUTERINE GROWTH RETARDATION; LUNG HEMORRHAGE; MEAN CORPUSCULAR HEMOGLOBIN; MEAN CORPUSCULAR VOLUME; METABOLIC ACIDOSIS; MOLECULAR GENETICS; NEWBORN; NEWBORN INTENSIVE CARE; OLIGOHYDRAMNIOS; PREMATURITY; PULMONARY HYPERTENSION;

ADULT; FATAL OUTCOME; FEMALE; FETAL GROWTH RETARDATION; HOMOZYGOTE; HUMANS; HYDROPS FETALIS; INFANT, NEWBORN; INFANT, PREMATURE; INFANT, PREMATURE, DISEASES; MALE; PREGNANCY;

EID: 38949187181     PISSN: 07438346     EISSN: 14765543     Source Type: Journal    
DOI: 10.1038/sj.jp.7211873     Document Type: Article

References (16)

1. Zaisov P, Matoth Y. Red cell values on the first postnatal day during the lost 16 weeks of gestation. Am J Hematol 1976; 1: 272-278.
2. Lie-Injo LE. Alpha-chain thalassemia and hydrops fetalis in Malaya: report of five cases. Blood 1962; 5: 581-590.
3. Tan SL, Tseng AM, Thong PW. Bart's hydrops fetalis - clinical presentation and management - an analysis of 25 cases. Aust NZ J Obstet Gynaecol 1989; 29: 233-237.
4. Shyur SD, Shih CC, Hung HY, Lin-Chu M, Liang DC, Lan CC et al. Non-hydropic cases in homosygous alpha thalassemia: Report of 3 cases. J. Formosan Med Assoc 1997; 86: 438-441.
5. Monaco SE, Davis M, Huang AC, Bhagat G, Baergen RN, Lorenz JM et al Alpha-thalassemia major presenting in a term neonate without hydrops. Pediatr Dev Pathol 2005; 8: 706-709.
6. Weatherall DJ. The thalassaemias. BMJ 1997; 314: 1675-1678.
7. Thiolo EH, Curlander JB, Hay WW. Pulse oximetry. In: Brans YW and Hay WW (eds). Physiological Monitoring and Instrument Diagnosis in Perinatal and Neonatal Medicine. Cambridge University Press: Cambridge, New York, 1995; pp 147-161.
8. Pologe JA, Raley DM. Effects of fetal hemoglobin on pulse oximetry. J Perinatol 1987; 7: 423-426.
9. Dame C, Albers N, Hasan C, Bode U, Eigel A, Hansmann M et al. Homozygous alpha-thalassaemia and hypospadias - common etiology or incidental association? Eur J Pediatr 1999; 158: 217-220.
10. Fung TY, Kin LT, Kong LC, Keung LC. Homozygous alpha-thalassemia associated with hypospadias in three survivors. Am J Med Genet 2000; 95: 287-290.
11. Gagnon R, Harding R, Brace RA. Amniotic fluid and fetal urinary responses to severe placental insufficiency in sheep. Am J Obstet Gynecol 2002; 186: 1076-1094.
12. Bain BJ, Amos RJ, Bareford D, Chapman C, Davies SC, Old JM, et al. for the General Haematology Task Force of the British Committee for Standards in Haematology. Guidelines on the laboratory diagnosis of haemoglobinopathies. Br J Haematol 1998; 101: 783-792.
13. NHS Antenatal and Newborn Screening Programmes: Sickle cell and thalassaemia. Handbook for Laboratories Sept 2006 (accessed online 29 October 2007 at http://www.sickleandthal.org.uk/Documents/ Labhandbook2006.pdf).
14. Chui DHK, Wave JS. Hydrops fetalis caused by α-thalassemia: An emerging health care problem. Blood 1998, 91: 2213-2222.
15. Kham SK, Quah TC, Loong AM, Tan PL, Fraser A, Chong SS et al. A molecular epidemiologic study of thalassemia using newborns' cord blood in a multiracial Asian population in Singapore: Results and recommendations for a population screening program. J Pediatr Hematol Oncol 2004; 26: 817-819.
16. Hofstaetter C, Gonsen M, Goelz R. Perinatal case report of unexpected thalassemia Hb Bart. Fetal Diagn Ther 1993; 8: 418-422.