Influence of bone marrow fat embolism on coagulation activation in an ovine model of vertebroplasty

Journal of Bone and Joint Surgery

Volumn 90, Issue 2, 2008, Pages 349-356

  Krebs, Jörg ^a   Ferguson, Stephen J ^a   Hoerstrup, Simon P ^b   Goss, Ben G ^c   Haeberli, André ^d   Aebli, Nikolaus ^e  

^a UNIVERSITY OF BERN   (Switzerland)

^b UNIVERSITY OF ZURICH   (Switzerland)

^c PRINCESS ALEXANDRA HOSPITAL   (Australia)

^d UNIVERSITY OF BERN   (Switzerland)

^e SWISS PARAPLEGIC RESEARCH   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

POLY(METHYL METHACRYLATE); BONE CEMENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD CLOTTING; BONE MARROW; CONTROLLED STUDY; EWE; FAT EMBOLISM; FEMALE; HEMOSTASIS; HISTOPATHOLOGY; LUNG EMBOLISM; NONHUMAN; PERCUTANEOUS VERTEBROPLASTY; PEROPERATIVE COMPLICATION; PRIORITY JOURNAL; ANIMAL; BONE MARROW CELL; DISEASE MODEL; LUNG; PATHOLOGY; PHYSIOLOGY; SHEEP;

ANIMALS; BLOOD COAGULATION; BONE CEMENTS; BONE MARROW CELLS; DISEASE MODELS, ANIMAL; EMBOLISM, FAT; FEMALE; LUNG; POLYMETHYL METHACRYLATE; PULMONARY EMBOLISM; SHEEP; VERTEBROPLASTY;

EID: 38949173956     PISSN: 00219355     EISSN: None     Source Type: Journal    
DOI: 10.2106/JBJS.G.00058     Document Type: Article

References (45)

1. K. Stricker R. Orler K. Yen J. Takala M. Luginbuhl Severe hypercapnia due to pulmonary embolism of polymethylmethacrylate during vertebroplasty Anesth Analg 98 2004 1184 1186
2. J.S. Jang S.H. Lee S.K. Jung Pulmonary embolism of polymethylmethacrylate after percutaneous vertebroplasty: a report of three cases Spine 27 2002 E416 E418
3. A.P. Amar D.W. Larsen N. Esnaashari F.C. Albuquerque S.D. Lavine G.P. Teitelbaum Percutaneous transpedicular polymethylmethacrylate vertebroplasty for the treatment of spinal compression fractures Neurosurgery 49 2001 1105 1115
4. C. Vasconcelos P. Gailloud J.B. Martin K.J. Murphy Transient arterial hypotension induced by polymethylmethacrylate injection during percutaneous vertebroplasty J Vasc Interv Radiol 12 2001 1001 1002
5. M. Sesay V. Dousset D. Liguoro F. Pehourcq J.M. Caille P. Maurette Intraosseous lidocaine provides effective analgesia for percutaneous vertebroplasty of osteoporotic fractures Can J Anaesth 49 2002 137 143
6. D.A. Nussbaum P. Gailloud K. Murphy A review of complications associated with vertebroplasty and kyphoplasty as reported to the Food and Drug Administration medical device related web site J Vasc Interv Radiol 15 2004 1185 1192
7. H.L. Chen C.S. Wong S.T. Ho F.L. Chang C.H. Hsu C.T. Wu A lethal pulmonary embolism during percutaneous vertebroplasty Anesth Analg 95 2002 1060 1062
8. J.C. Childers Jr. Cardiovascular collapse and death during vertebroplasty Radiology 228 2003 902 903
9. M.I. Syed S. Jan N.A. Patel A. Shaikh R.A. Marsh R.V. Stewart Fatal fat embolism after vertebroplasty: identification of the high-risk patient AJNR Am J Neuroradiol 27 2006 343 345
10. N. Aebli J. Krebs G. Davis M. Walton M.J. Williams J.C. Theis Fat embolism and acute hypotension during vertebroplasty: an experimental study in sheep Spine 27 2002 460 466
11. N. Aebli D. Schwenke G. Davis T. Hii J.C. Theis J. Krebs Polymethylmethacrylate causes prolonged pulmonary hypertension during fat embolism: a study in sheep Acta Orthop 76 2005 904 911
12. Y.H. Kim S.W. Oh J.S. Kim Prevalence of fat embolism following bilateral simultaneous and unilateral total hip arthroplasty performed with or without cement: a prospective, randomized clinical study J Bone Joint Surg Am 84 2002 1372 1379
13. J. Parvizi A.D. Holiday M.H. Ereth D.G. Lewallen Sudden death during primary hip arthroplasty Clin Orthop Relat Res 369 1999 39 48
14. N.R. Fahmy H.P. Chandler K. Danylchuk E.B. Matta N. Sunder J.M. Siliski Blood-gas and circulatory changes during total knee replacement. Role of the intramedullary alignment rod J Bone Joint Surg Am 72 1990 19 26
15. L.G. Morawa M.T. Manley A.A. Edidin D.T. Reilly Transesophageal echocardiographic monitored events during total knee arthroplasty Clin Orthop Relat Res 331 1996 192 198
16. R.C. Talucci J. Manning S. Lampard A. Bach C.J. Carrico Early intramedullary nailing of femoral shaft fractures: a cause of fat embolism syndrome Am J Surg 146 1983 107 111
17. A.C. Pell J. Christie J.F. Keating G.R. Sutherland The detection of fat embolism by transoesophageal echocardiography during reamed intramedullary nailing. A study of 24 patients with femoral and tibial fractures J Bone Joint Surg Br 75 1993 921 925
18. S. Takahashi H. Kitagawa T. Ishii Intraoperative pulmonary embolism during spinal instrumentation surgery. A prospective study using transoesophageal echocardiography J Bone Joint Surg Br 85 2003 90 94
19. J.D. Temple S.C. Ludwig W.K. Ross W.K. Marshall L. Larsen D.E. Gelb Catastrophic fat embolism following augmentation of pedicle screws with bone cement: a case report J Bone Joint Surg Am 84 2002 639 642
20. N. Aebli J. Krebs D. Schwenke G. Davis J.C. Theis Cardiovascular changes during multiple vertebroplasty with and without vent-hole: an experimental study in sheep Spine 28 2003 1504 1512
21. R.P. Pitto H. Hamer R. Fabiani M. Radespiel-Troeger M. Koessler Prophylaxis against fat and bone-marrow embolism during total hip arthroplasty reduces the incidence of postoperative deep-vein thrombosis: a controlled, randomized clinical trial J Bone Joint Surg Am 84 2002 39 48
22. J. Modig C. Busch S. Olerud T. Saldeen G. Waernbaum Arterial hypotension and hypoxaemia during total hip replacement: the importance of thromboplastic products, fat embolism and acrylic monomers Acta Anaesthesiol Scand 19 1975 28 43
23. N.E. Sharrock G. Go P.C. Harpel C.S. Ranawat T.P. Sculco E.A. Salvati Thrombogenesis during total hip arthroplasty Clin Orthop Relat Res 319 1995 16 27
24. O.E. Dahl H. Johnsen P. Kierulf I. Molnar J.S. Ro A. Vinje P. Mowinckel Intrapulmonary thrombin generation and its relation to monomethylmethacrylate plasma levels during hip arthroplasty Acta Anaesthesiol Scand 36 1992 331 335
25. G. Hallin J. Modig L. Nordgren S. Olerud The intramedullary pressure during the bone marrow trauma of total hip replacement surgery Ups J Med Sci 79 1974 51 54
26. K. Murakami R. McGuire R.A. Cox J.M. Jodoin F.C. Schmalstieg L.D. Traber H.K. Hawkins D.N. Herndon D.L. Traber Recombinant antithrombin attenuates pulmonary inflammation following smoke inhalation and pneumonia in sheep Crit Care Med 31 2003 577 583
27. P.S. Barie A.B. Malik Role of intravascular coagulation and granulocytes in lung vascular injury after bone marrow embolism Circ Res 50 1982 830 838
28. D. Heim P. Regazzoni D.A. Tsakiris T. Aebi U. Schlegel G.A. Marbet S.M. Perren Intramedullary nailing and pulmonary embolism: does unreamed nailing prevent embolization? An in vivo study in rabbits J Trauma 38 1995 899 906
29. P.S. Barie F.L. Minnear A.B. Malik Increased pulmonary vascular permeability after bone marrow injection in sheep Am Rev Respir Dis 123 1981 648 653
30. C.M. Bernards J. Chapman S. Mirza Lethality of embolized Norian bone cement varies with the time between mixing and embolization Proceedings of the 50th Annual Meeting of the Orthopaedic Research Society 2004 Mar 7-10; San Francisco, CA. Poster n.o. 254
31. A. Blinc M. Bozic R. Vengust M. Stegnar Methyl-methacrylate bone cement surface does not promote platelet aggregation or plasma coagulation in vitro Thromb Res 114 2004 179 184
32. J. Krebs N. Aebli B.G. Goss K. Wilson R. Williams S.J. Ferguson Cardiovascular changes after pulmonary cement embolism: an experimental study in sheep AJNR Am J Neuroradiol 28 2007 1046 1050
33. J. Krebs N. Aebli B.G. Goss S. Sugiyama T. Bardyn I. Boecken P.J. Leamy S.J. Ferguson Cardiovascular changes after pulmonary embolism from injecting calcium phosphate cement J Biomed Mater Res B Appl Biomater 82 2007 526 532
34. R.J. Byrick Fat embolism and postoperative coagulopathy Can J Anaesth 48 2001 618 621
35. B. Steinberg C.S. Mundy Experimental pulmonary embolism and infarction Arch Pathol 22 1936 539 542
36. G.E. Haggart A.M. Walker The physiology of pulmonary embolism as disclosed by quantitative occlusion of the pulmonary artery Arch Surg 6 1923 764 783
37. K. Mohanty J.N. Powell D. Musso M. Traboulsi I. Belenkie J.B. Mullen J.V. Tyberg The effect of a venous filter on the embolic load during medullary canal pressurization: a canine study J Bone Joint Surg Am 87 2005 1332 1337
38. E.F. Wheelwright R.J. Byrick D.F. Wigglesworth J.C. Kay P.Y. Wong J.B. Mullen J.P. Waddell Hypotension during cemented arthroplasty. Relationship to cardiac output and fat embolism J Bone Joint Surg Br 75 1993 715 723
39. Y.M. Smulders Pathophysiology and treatment of haemodynamic instability in acute pulmonary embolism: the pivotal role of pulmonary vasoconstriction Cardiovasc Res 48 2000 23 33
40. J. Hyland G. Smith L. McGuire D. Harrison F.W. Haynes L. Dexter Effect of selective embolization of various sized pulmonary arteries in dogs Am J Physiol 204 1963 619 625
41. D. Halmagyi H. Colebatch Cardiorespiratory effects of experimental lung embolism J Clin Invest 40 1961 1785 1796
42. I. Johansen J. Benumof Methylmethacrylate and the cardiovascular system Anaesth Rev 4 1977 27 32
43. R.P. Fairman C. Morrow F.L. Glauser Methylmethacrylate induces pulmonary hypertension and increases lung vascular permeability in sheep Am Rev Respir Dis 130 1984 92 95
44. R.E. McLaughlin C.A. DiFazio M. Hakala B. Abbott J.A. MacPhail W.P. Mack D.E. Sweet Blood clearance and acute pulmonary toxicity of methylmethacrylate in dogs after simulated arthroplasty and intravenous injection J Bone Joint Surg Am 55 1973 1621 1628
45. J. Modig C. Busch G. Waernbaum Effects of graded infusions of monomethylmethacrylate on coagulation, blood lipids, respiration and circulation. An experimental study in dogs Clin Orthop Relat Res 113 1975 187 197