Haplotype mapping of a diploid non-meiotic organism using existing and induced aneuploidies

PLoS Genetics

Volumn 4, Issue 1, 2008, Pages 0018-0028

  Legrand, Melanie ^a   Forche, Anja ^a   Selmecki, Anna ^a   Chan, Christine ^a   Kirkpatrick, David T ^a   Berman, Judith ^a  

^a UNIVERSITY OF MINNESOTA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANEUPLOIDY; ARTICLE; CANDIDA ALBICANS; CHROMOSOME LOSS; CHROMOSOME PAIRING; CLONE; DIPLOIDY; FUNGAL STRAIN; FUNGUS ISOLATION; GENE; GENE CASSETTE; GENE CONVERSION; GENE DELETION; GENE INSERTION; GENE MAPPING; GENE REARRANGEMENT; GENE SEGREGATION; GENE SEQUENCE; GENE TARGETING; GENETIC RECOMBINATION; GENETIC VARIABILITY; HAPLOTYPE; HOMOZYGOTE; MEIOSIS; MITOTIC RECOMBINATION; NONHUMAN; ORC1 GENE; PROGENY; SINGLE NUCLEOTIDE POLYMORPHISM; TRISOMY; ALLELE; CHROMOSOME; CHROMOSOME MAP; CYTOLOGY; GENETICS; HETEROZYGOSITY LOSS; ISOLATION AND PURIFICATION; MOLECULAR GENETICS; NUCLEOTIDE SEQUENCE;

CANDIDA ALBICANS;

ALLELES; ANEUPLOIDY; BASE SEQUENCE; CANDIDA ALBICANS; CHROMOSOME MAPPING; CHROMOSOMES, FUNGAL; DIPLOIDY; HAPLOTYPES; LOSS OF HETEROZYGOSITY; MEIOSIS; MOLECULAR SEQUENCE DATA; POLYMORPHISM, SINGLE NUCLEOTIDE; RECOMBINATION, GENETIC; TRISOMY;

EID: 38949170722     PISSN: 15537390     EISSN: 15537404     Source Type: Journal    
DOI: 10.1371/journal.pgen.0040001     Document Type: Article

References (24)

1. Gibbs RA and 172 co-authors (2003) The International HapMap Project. Nature 426: 789-796.
2. Glinsky GV (2006) Integration of HapMap-based SNP pattern analysis and gene expression profiling reveals common SNP profiles for cancer therapy outcome predictor genes. Cell Cycle 5: 2613-2625.
3. Guryev V, Smits BM, van de Belt J, Verheul M, Hubner N, et al. (2006) Haplotype block structure is conserved across mammals. PLoS genetics 2: e121. doi: 10.1371/journal.pgen.0020121
4. Selmecki A, Forche A, Berman J (2006) Aneuploidy and isochromosome formation in drug-resistant Candida albicans. Science 313: 367-370.
5. Jones T, Federspiel NA, Chibana H, Dungan J, Kalman S, et al. (2004) The diploid genome sequence of Candida albicans. Proc Natl Acad Sci U S A 101: 7329-7334.
6. Holmes AR, Tsao S, Ong SW, Lamping E, Niimi K, et al. (2006) Heterozygosity and functional allelic variation in the Candida albicans efflux pump genes CDR1 and CDR2. Mol Microbiol 62: 170-186.
7. Forche A, May G, Magee PT (2005) Demonstration of loss of heterozygosity by single-nucleotide polymorphism microarray analysis and alterations in strain morphology in Candida albicans strains during infection. Eukaryot Cell 4: 156-165.
8. Chen X, Magee BB, Dawson D, Magee PT, Kumamoto CA (2004) Chromosome 1 trisomy compromises the virulence of Candida albicans. Mol Microbiol 51: 551-565.
9. Selmecki A, Bergmann S, Berman J (2005) Comparative genome hybridization reveals widespread aneuploidy in Candida albicans laboratory strains. Mol Microbiol 55: 1553-1565.
10. Wellington M, Kabir MA, Rustchenko E (2006) 5-fluoro-orotic acid induces chromosome alterations in genetically manipulated strains of Candida albicans. Mycologia 98: 393-398.
11. Janbon G, Sherman F, Rustchenko E (1998) Monosomy of a specific chromosome determines L-sorbose utilization: a novel regulatory mechanism in Candida albicans. Proc Natl Acad Sci U S A 95: 5150-5155.
12. Wu W, Pujol C, Lockhart SR, Soll DR (2005) Chromosome loss followed by duplication is the major mechanism of spontaneous mating-type locus homozygosis in Candida albicans. Genetics 169: 1311-1327.
13. Perepnikhatka V, Fischer FJ, Niimi M, Baker RA, Cannon RD, et al. (1999) Specific chromosome alterations in fluconazole-resistant mutants of Candida albicans. J Bacteriol 181: 4041-4049.
14. Rustchenko E (2007) Chromosome instability in Candida albicans. FEMS Yeast Res 7: 2-11.
15. Enloe B, Diamond A, Mitchell AP (2000) A single-transformation gene function test in diploid Candida albicans. J Bacteriol 182: 5730-5736.
16. Cowen LE, Sirjusingh C, Summerbell RC, Walmsley S, Richardson S, et al. (1999) Multilocus genotypes and DNA fingerprints do not predict variation in azole resistance among clinical isolates of Candida albicans. Antimicrob Agents Chemother 43: 2930-2938.
17. Cowen LE, Sanglard D, Calabrese D, Sirjusingh C, Anderson JB, et al. (2000) Evolution of drug resistance in experimental populations of Candida albicans. J Bacteriol 182: 1515-1522.
18. Noble SM, Johnson AD (2005) Strains and strategies for large-scale gene deletion studies of the diploid human fungal pathogen Candida albicans. Eukaryot Cell 4: 298-309.
19. Wilson RB, Davis D, Mitchell AP (1999) Rapid hypothesis testing with Candida albicans through gene disruption with short homology regions. J Bacteriol 181: 1868-1874.
20. Forche A, Magee PT, Magee BB, May G (2004) Genome-wide single-nucleotide polymorphism map for Candida albicans. Eukaryot Cell 3: 705-714.
21. Chibana H, Beckerman JL, Magee PT (2000) Fine-resolution physical mapping of genomic diversity in Candida albicans. Genome Res 10: 1865-1877.
22. Legrand M, Lephart P, Forche A, Mueller FM, Walsh T, et al. (2004) Homozygosity at the MTL locus in clinical strains of Candida albicans: karyotypic rearrangements and tetraploid formation. Mol Microbiol 52: 1451-1462.
23. Lockhart SR, Pujol C, Daniels KJ, Miller MG, Johnson AD, et al. (2002) In Candida albicans, white-opaque switchers are homozygous for mating type. Genetics 162: 737-745.
24. Wu W, Lockhart SR, Pujol C, Srikantha T, Soll DR (2007) Heterozygosity of genes on the sex chromosome regulates Candida albicans virulence. Mol Microbiol 64: 1587-1604.