Alemtuzumab (Campath-1H) Induction in a Pediatric Heart Transplant: Successful Outcome and Rationale for Its Use

Journal of Heart and Lung Transplantation

Volumn 27, Issue 2, 2008, Pages 242-244

  Das, Bibhuti ^a   Shoemaker, Lawrence ^a   Recto, Michael ^a   Austin, Erle ^a   Dowling, Robert ^a  

^a University of Louisville School of Medicine   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALEMTUZUMAB; METHYLPREDNISOLONE; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; TACROLIMUS;

ADOLESCENT; ARTICLE; B LYMPHOCYTE; CASE REPORT; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CONGESTIVE CARDIOMYOPATHY; CYTOKINE RELEASE; DISEASE SEVERITY; FEMALE; FLOW CYTOMETRY; GRAFT REJECTION; GRAFT SURVIVAL; HEART CATHETERIZATION; HEART FAILURE; HEART MUSCLE BIOPSY; HEART TRANSPLANTATION; HUMAN; LEUKOCYTE COUNT; ORTHOTOPIC TRANSPLANTATION; PEDIATRIC SURGERY; POSTOPERATIVE PERIOD; PRIORITY JOURNAL; TREATMENT OUTCOME;

ADOLESCENT; ANTIBODIES, MONOCLONAL; ANTIBODIES, NEOPLASM; CARDIOMYOPATHY, DILATED; DRUG ADMINISTRATION SCHEDULE; DRUG THERAPY, COMBINATION; FEMALE; FOLLOW-UP STUDIES; GRAFT REJECTION; HEART FAILURE; HEART TRANSPLANTATION; HUMANS; IMMUNOSUPPRESSIVE AGENTS; POSTOPERATIVE CARE; RISK ASSESSMENT; TRANSPLANTATION IMMUNOLOGY; TRANSPLANTATION, HOMOLOGOUS; TREATMENT OUTCOME;

EID: 38949153071     PISSN: 10532498     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.healun.2007.11.569     Document Type: Article

References (15)

1. Hale G. The CD52 antigen and development of the CAMPATH antibodies. Cytotherapy 3 (2001) 137-143
2. Riechman L., Clark M., Waldmann H., et al. Reshaping human antibodies for therapy. Nature 332 (1988) 323-327
3. Morris P.J., and Russell N.K. Alemtuzumab (Campath-1H): a systematic review in organ transplantation. Transplantation 81 (2006) 1361-1367
4. Calne R., Friend P., Moffatt S., et al. Prope tolerance, perioperative Campath 1H, and low-dose cyclosporin monotherapy in renal allograft recipients. Lancet 351 (1998) 1701-1702
5. Vathsala A., Ona E.T., Tan S., et al. Randomized trial of alemtuzumab for prevention of graft rejection and preservation of renal function after kidney transplantation. Transplantation 80 (2005) 765-774
6. Ciancio G., Burke G.W., Gaynor J.J., et al. A randomized trial of three renal transplant induction antibodies: early comparison of tacrolimus, mycophenolate mofetil, and steroid dosing, and newer immune-monitoring. Transplantation 80 (2005) 457-465
7. Silveira F.P., Marcos A., Kwak E.J., et al. Blood stream infections in organ transplant recipients receiving alemtuzumab: no evidence of occurrence of organisms typically associated with profound T cell depletion. J Infect Dis 53 (2006) 241-247
8. Malek S.K., Obman M.A., Gotoff R., et al. Campath-1H induction and the incidence of infectious complications in adult renal transplantation. Transplantation 81 (2006) 17-20
9. Coles A.J., Wing M., Smith S., et al. Pulsed monoclonal antibody treatment and autoimmune thyroid disease in multiple sclerosis. Lancet 354 (1999) 1691-1695
10. Watson C.J.E., Bradley J.A., Friend P.J., et al. Alemtuzumab (CAMPATH 1H) induction therapy in cadaveric kidney transplantation-efficacy and safety at five years. Am J Transplant 5 (2005) 1347-1353
11. Hale G., and Waldmann H. Risks of developing Epstein-Barr virus related lymphoproliferative disorders after T-cell-depleted marrow transplants. CAMPATH users. Blood 91 (1998) 3079-3083
12. Bartosh S.M., Knechtle S.J., and Sollinger H.W. Campath-1H use in pediatric renal transplantation. Am J Transplant 5 (2005) 1569-1573
13. Kato T., Gaynor J.J., Selvaggi G., et al. Intestinal transplantation in children: a summary of clinical outcomes and prognostic factors in 108 patients from a single center. J Gastrointest Surg 9 (2005) 75-89
14. Kato T., Tzakis A.G., Selvaggi G., et al. Intestinal and multivisceral transplantation in children. Ann Surg 243 (2006) 756-766
15. Miyamoto S.D., Gilbert D., Ballard A., et al. Campath-1H therapy for resistant rejection in pediatric heart transplant patients. J Heart Lung Transplant 26 suppl (2007) S246-S247