Radical fluoroarylation in radiochemical synthesis

Tetrahedron Letters

Volumn 49, Issue 11, 2008, Pages 1881-1883

  Hultsch, Christina ^a   Blank, Olga ^b   Wester, Hans Jürgen ^a   Heinrich, Markus R ^b  

^a TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^b TECHNICAL UNIVERSITY OF MUNICH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ALKENE DERIVATIVE; ARECOLINE; FLUOROBENZENE; PHENYL GROUP; POLYCYCLIC AROMATIC HYDROCARBON DERIVATIVE; RADIOPHARMACEUTICAL AGENT; STILBENE DERIVATIVE; STYRENE DERIVATIVE;

ARTICLE; ARYLATION; CHEMICAL REACTION; FLUORINATION; RADIOCHEMISTRY; REACTION TIME; STEREOCHEMISTRY; SYNTHESIS;

EID: 38949151586     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tetlet.2007.12.128     Document Type: Article

References (18)

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7. General procedure for the non-radioactive fluoroarylation (Table 1, Column 2): To a solution of the substrate (4 mmol) in aqueous titanium(III) chloride (3 mL, ca. 1 M solution in dilute hydrochloric acid, ca. 3.0 mmol) 4-fluorobenzenediazonium tetrafluoroborate (209 mg, 1.0 mmol) was added in one batch. The resulting solution was stirred under argon at 45 °C for 20 min and diluted with water (5 mL). After the careful addition of satd aqueous sodium carbonate (30 mL) the mixture was extracted with ether (3 × 20 mL). The combined extracts were dried over sodium sulfate and concentrated. Purification was achieved by column chromatography.
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