Evaluation of the NO-releasing properties of NO-donor linkers

Journal of Pharmacy and Pharmacology

Volumn 60, Issue 2, 2008, Pages 189-195

  Calderone, Vincenzo ^a   Digiacomo, Maria ^a   Martelli, Alma ^a   Minutolo, Filippo ^a   Rapposelli, Simona ^a   Testai, Lara ^a   Balsamo, Aldo ^a  

^a UNIVERSITY OF PISA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

1 [3 (HYDROXYMETHYL)PHENYL]ETHYL NITRATE; 1[4 (HYDROXYMETHYL)PHENYL]ETHYL NITRATE; 3 (HYDROXYMETHYL)BENZYL NITRATE; 3 [(NITROOXY)METHYL]BENZOIC ACID; 4 (HYDROXYMETHYL)BENZYL NITRATE; 4 [(NITROOXY)METHYL]BENZOIC ACID; BENZOIC ACID DERIVATIVE; NITRIC ACID DERIVATIVE; NITRIC OXIDE DONOR; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AORTA; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFECT; DRUG SYNTHESIS; HALOGENATION; IC 50; IN VITRO STUDY; NONHUMAN; RAT; VASCULAR RING; VASODILATATION;

ANIMALS; AORTA, THORACIC; BENZOIC ACIDS; BENZYL ALCOHOLS; CARBOXYLIC ACIDS; MALE; NITRIC OXIDE; NITRIC OXIDE DONORS; POTASSIUM CHLORIDE; RATS; RATS, WISTAR; STRUCTURE-ACTIVITY RELATIONSHIP; VASOCONSTRICTION; VASODILATION;

EID: 38949140483     PISSN: 00223573     EISSN: None     Source Type: Journal    
DOI: 10.1211/jpp.60.2.0007     Document Type: Article

References (13)

1. Baraldi, P. G., Romagnoli, R., Del Carmen Nunez, M., Perretti, M., Paul-Clark, M. J., Ferrario, M., Govoni, M., Benedini, F., Ongini, E. (2004) Synthesis of nitro esters of prednisolone, new compounds combining pharmacological properties of both glucocorticoids and nitric oxide. J. Med. Chem. 47: 711-719
2. Breschi, M. C., Calderone, V., Digiacomo, M., Martelli, A., Martinotti, E., Minutolo, F., Rapposelli, S., Balsamo, A. (2004) NO-sartans: a new class of pharmacodynamic hybrids as cardiovascular drugs. J. Med. Chem. 47: 5597-5600
3. Breschi, M. C., Calderone, V., Digiacomo, M., Macchia, M., Martelli, A., Martinotti, E., Minutolo, F., Rapposelli, S., Rossello, A., Testai, L., Balsamo, A. (2006) New NO-releasing pharmacodynamic hybrids of losartan and its active metabolite: design, synthesis, and biopharmacological properties. J. Med. Chem. 49: 2628-2639
4. Eisen, S. A., Miller, D. K., Woodward, R. S., Spitznagel, E., Przybeck, T. R. (1990) The effect of prescribed daily dose frequency on patient medication compliance. Arch. Intern. Med. 150: 1881-1884
5. Furlong, B., Henderson, A. H., Lewis, M. J., Smith, J. A. (1987) Endothelium-derived relaxing factor inhibits in vitro platelet aggregation. Br. J. Pharmacol. 90: 687-692
6. Martelli, A., Rapposelli, S., Calderone, V. (2006) NO-releasing hybrids of cardiovascular drugs. Curr. Med. Chem. 13: 609-625
7. Minuz, P., Lechi, C., Zuliani, V., Tommasoli, R., Lechi, A. (1998) NO-Aspirins: antithrombotic activity of derivatives of acetyl salicylic acid releasing nitric oxide. Cardiovasc. Drug Rev. 16: 31-47
8. Morphy, R., Rankovic, Z. (2006) The physicochemical challenges of designing multiple ligands. J. Med. Chem. 49: 4961-4970
9. Nakano, A., Liu, G., Heusch, G., Downey, J. M., Cohen, M. V. (2000) Exogenous nitric oxide can trigger a preconditioned state through a free radical mechanism, but endogenous nitric oxide is not a trigger of classical ischemic preconditioning. J. Mol. Cell. Cardiol. 32: 1159-1167
10. Qin, Q., Yang, X. M., Cui, L., Critz, S. D., Cohen, M. V., Browner, N. C., Lincoln, T. M., Downey, J. M. (2004) Exogenous NO triggers preconditioning via a cGMP- and mitoKATP-dependent mechanism. Am. J. Physiol. Heart Circ. Physiol. 287: H712-718
11. Radomski, M. W., Palmer, R. M. J., Moncada, S. (1990) Glucocorticoids inhibit the expression of an inducible, but not the constitutive, nitric oxide synthase in vascular endothelial cells. Proc. Natl. Acad. Sci. USA 87: 10043-10047
12. Shaffer, J. E., Lee, F., Thomson, S., Han, B. J., Cooke, J. P., Loscalzo, J. (1991) The hemodynamic effects of S-nitrosocaptopril in anesthetized dogs. J. Pharmacol. Exp. Ther. 256: 704-709
13. Villarroya, M., Herrero, C. J., Ruiz-Nuno, A., De Pascual, R., Del Valle, M., Michelena, P., Grau, M., Carrasco, E., Lopez, M. G., Garcia, A. G. (1999) PF9404C, a new slow NO donor with beta receptor blocking properties. Br. J. Pharmacol. 128: 1713-1722