Up-and-down designs for selecting the dose with maximum success probability

Sequential Analysis

Volumn 27, Issue 1, 2008, Pages 78-96

  Kpamegan, E E ^a   Flournoy, N ^b  

^a FOREST RESEARCH INSTITUTE   (United States)

^b UNIVERSITY OF MISSOURI   (United States)

Author keywords

Constant gain stochastic algorithm; Dose finding; Efficacy; Markov chains; Optimal dose; Phase I II clinical trial; Random walk designs; Stationary treatment distribution; Stochastic approximation; Toxicity; Unimodality

Indexed keywords

DOSE-FINDING; EFFICACY; OPTIMAL DOSE; PHASE I/II CLINICAL TRIALS; RANDOM WALK; STATIONARY TREATMENT DISTRIBUTION; STOCHASTIC ALGORITHMS; STOCHASTIC APPROXIMATIONS; UNIMODALITY;

APPROXIMATION THEORY; DESIGN; MARKOV PROCESSES; OPTIMIZATION; PATIENT TREATMENT; TOXICITY;

DRUG DOSAGE;

EID: 38949140126     PISSN: 07474946     EISSN: 15324176     Source Type: Journal    
DOI: 10.1080/07474940701802034     Document Type: Article

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