Platelets play a direct role in sepsis-associated endothelial cell death

Thrombosis and Haemostasis

Volumn 99, Issue 2, 2008, Pages 249-

  Semple, John W ^a  

^a ST MICHAEL'S HOSPITAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

APOPTOSIS; CELL DEATH; CELL INTERACTION; EDITORIAL; ENDOTHELIUM CELL; HUMAN; INFLAMMATION; PRIORITY JOURNAL; SEPSIS; THROMBOCYTE; THROMBOSIS; VASCULITIS;

ANIMALS; APOPTOSIS; BLOOD PLATELETS; CASPASE 3; CASPASE 8; CASPASE 9; CATTLE; CELLS, CULTURED; CULTURE MEDIA, CONDITIONED; ENDOTHELIAL CELLS; ENZYME ACTIVATION; FAS LIGAND PROTEIN; HAEMOPHILUS SOMNUS; HUMANS; PLATELET ACTIVATION; REACTIVE OXYGEN SPECIES; SEPSIS; TIME FACTORS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 38949133879     PISSN: 03406245     EISSN: None     Source Type: Journal    
DOI: 10.1160/TH08-01-0010     Document Type: Editorial

References (4)

1. Aslam R, Speck ER, Kim M, et al. et al. Platelet Toll-like receptor expression modulates lipopolysaccharide-induced thrombocytopenia and tumor necrosis factor-production in vivo. Blood 2006; 107: 637-641.
2. Clark SR, Ma AC, Tavener SA, et al. Platelet TLR4 activates neutrophil extracellular traps to ensnare bacteria in septic blood. Nature Med 2007; 13: 463-469.
3. Semple JW, Aslam R, Kim M, et al. Platelet-bound lipopolysaccharide enhances Fc receptor-mediated phagocytosis of IgG opsonized platelets. Blood 2007; 109: 4803-4805.
4. Kuckleburg CJ, Tiwari R, Czuprynski CJ. Endothelial cell apoptosis induced by bacteria-activated platelets requires caspase-8 and -9 and generation of reactive oxygen species. Thromb Haemost 2008; 99: 363-372.