Non-isotopic tyrosine kinetics using an alanyl-tyrosine dipeptide to assess graft function in liver transplant recipients - A pilot study

Wiener Klinische Wochenschrift

Volumn 120, Issue 1-2, 2008, Pages 19-24

  Krenn, Claus G ^a,b   Pokorny, Herwig ^a   Hoerauf, Klaus ^a   Stark, Josef ^a   Roth, Erich ^a   Steltzer, Heinz ^a   Druml, Wilfred ^a  

^a MEDICAL UNIVERSITY OF VIENNA   (Austria)

^b UNIVERSITY OF VIENNA   (Austria)

Author keywords

Graft failure; Indocyanine green; Liver function test; Orthotopic liver transplantation; Tyrosine metabolism

Indexed keywords

ALANINE; ALANYL TYROSINE DIPEPTIDE; BIOLOGICAL MARKER; INDOCYANINE GREEN; PEPTIDE DERIVATIVE; TYROSINE; UNCLASSIFIED DRUG;

ADULT; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE SEVERITY; FEASIBILITY STUDY; FEMALE; GRAFT DYSFUNCTION; HUMAN; KIDNEY DONOR; KIDNEY FAILURE; KIDNEY PRESERVATION; LABORATORY TEST; LIVER FUNCTION; LIVER TRANSPLANTATION; MALE; MEDICAL ASSESSMENT; PILOT STUDY; PROTEIN BLOOD LEVEL; PROTEIN TRANSPORT; RECIPIENT;

ADULT; ALANINE TRANSAMINASE; ASPARTATE AMINOTRANSFERASES; DIPEPTIDES; FEASIBILITY STUDIES; FEMALE; HUMANS; INDOCYANINE GREEN; LIVER FAILURE; LIVER FUNCTION TESTS; LIVER TRANSPLANTATION; MALE; METABOLIC CLEARANCE RATE; MIDDLE AGED; PILOT PROJECTS; PREDICTIVE VALUE OF TESTS; TISSUE DONORS; TYROSINE;

EID: 38949126567     PISSN: 00435325     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00508-007-0908-y     Document Type: Article

References (37)

1. Sear JW (2002) Assessment of liver function: its application to outcome from liver transplantation. Br J Anaesth 88: 757-760
2. Shaked A, Nunes FA, Olthoff KM, Lucey MR (1997) Assessment of liver function: pre- and peritransplant evaluation. Clin Chem 43: 1539-1545
3. Renner EL (1995) Liver function tests. Baillieres Clin Gastroenterol 9: 661-677
4. Levine RJ, Conn HO (1967) Tyrosine metabolism in patients with liver disease. J Clin Invest 46: 2012-2020
5. Clowes GH Jr, McDermott WV, Williams LF, Loda M, Menzoian JO, Pearl R (1984) Amino acid clearance and prognosis in surgical patients with cirrhosis. Surgery 96: 675-685
6. Pittiruti M, Siegel JH, Sganga G, Coleman B, Wiles CE 3rd, Belzberg H, Wedel S, et al (1985) Increased dependence of leucine in posttraumatic sepsis: leucine/tyrosine clearance ratio as an indicator of hepatic impairment in septic multiple organ failure syndrome. Surgery 98: 378-387
7. Hehir DJ, Jenkins RL, Bistrian BR, Wagner D, Moldawer LL, Young VR, Blackburn GL (1985) Abnormal phenylalanine hydroxylation and tyrosine oxidation in a patient with acute fulminant liver disease with correction by liver transplantation. Gastroenterology 89: 659-663
8. Shanbhogue RL, Bistrian BR, Lakshman K, Crosby L, Swenson S, Wagner D, Jenkins RL, et al (1987) Whole body leucine, phenylalanine, and tyrosine kinetics in end-stage liver disease before and after hepatic transplantation. Metabolism 36: 1047-1053
9. Svensson KL, Persson H, Henriksson BA, Karlberg I, Sonander H, Lundholm K, Stenqvist O, et al (1989) Whole body gas exchange: amino acid and lactate clearance as indicators of initial and early allograft viability in liver transplantation. Surgery 105: 472-480
10. Druml W, Lochs H, Roth E, Hubl W, Balcke P, Lenz K (1991) Utilization of tyrosine dipeptides and acetyltyrosine in normal and uremic humans. Am J Physiol 260: E280-E285
11. Druml W, Hubl W, Roth E, Lochs H (1995) Utilization of tyrosine-containing dipeptides and N-acetyl-tyrosine in hepatic failure. Hepatology 21: 923-928
12. Krenn CG, Krafft P, Schaefer B, Pokorny H, Schneider B, Pinsky MR, Steltzer H (2000) Effects of positive end-expiratory pressure on hemodynamics and indocyanine green kinetics in patients after orthotopic liver transplantation. Crit Care Med 28: 1760-1765
13. Faybik P, Krenn CG, Baker A, Lahner D, Berlakovich G, Steltzer H, Hetz H (2004) Comparison of invasive and noninvasive measurement of plasma disappearance rate of indocyanine green in patients undergoing liver transplantation: a prospective investigator-blinded study. Liver Transpl 10: 1060-1064
14. Tanaka E, Inomata S, Yasuhara H (2000) The clinical importance of conventional and quantitative liver function tests in liver transplantation. J Clin Pharm Ther 25: 411-419
15. Hickman PE, Potter JM, Pesce AJ (1997) Clinical chemistry and post-liver-transplant monitoring. Clin Chem 43: 1546-1554
16. Dabos KJ, Newsome PN, Parkinson JA, Mohammed HH, Sadler IH, Plevris JN, Hayes PC (2004) Biochemical prognostic markers of outcome in non-paracetamol-induced fulminant hepatic failure. Transplantation 77: 200-205
17. Schmidt LE, Ott P, Tygstrup N (2004) Galactose elimination capacity as a prognostic marker in patients with severe acetaminophen-induced hepatotoxicity: 10 years' experience. Clin Gastroenterol Hepatol 2: 418-424
18. Tsubono T, Todo S, Jabbour N, Mizoe A, Warty V, Demetris AJ, Starzl TE (1996) Indocyanine green elimination test in orthotopic liver recipients. Hepatology 24: 1165-1171
19. Steltzer H, Tuchy G, Hiesmayr M, Muller C, Germann P, Zimpfer M (1992) Peri-operative liver graft function: monitoring using the relationship between blood glucose and oxygen consumption during anaesthesia. Anaesthesia 47: 955-958
20. Nagel RA, Dirix LY, Hayllar KM, Preisig R, Tredger JM, Williams R (1990) Use of quantitative liver function tests - caffeine clearance and galactose elimination capacity - after orthotopic liver transplantation. J Hepatol 10: 149-157
21. Lamesch P, Ringe B, Oellerich M, Burdelski M, Beyrau R, Gubernatis G, Pichlmayr R (1990) Assessment of liver function in the early postoperative period after liver transplantation with ICG, MEGX, and GAL tests. Transplant Proc 22: 1539-1541
22. Plevris JN, Jalan R, Bzeizi KI, Dollinger MM, Lee A, Garden OJ, Hayes PC (1999) Indocyanine green clearance reflects reperfusion injury following liver transplantation and is an early predictor of graft function. J Hepatol 30: 142-148
23. Mandell MS, Wachs M, Niemann CU, Henthorn TK (2002) Elimination of indocyanine green in the perioperative evaluation of donor liver function. Anesth Analg 95: 1182-1184
24. Krenn CG, Schafer B, Berlakovich GA, Steininger R, Steltzer H, Spiss CK (1998) Detection of graft nonfunction after liver transplantation by assessment of indocyanine green kinetics. Anesth Analg 87: 34-36
25. Conti F, Dousset B, Cherruau B, Guerin C, Soubrane O, Houssin D, Calmus Y (2004) Use of lidocaine metabolism to test liver function during the long-term follow-up of liver transplant recipients. Clin Transplant 18: 235-241
26. Addario L, Scaglione G, Tritto G, Di Costanzo GG, De Luca M, Lampasi F, Galeota Lanza A, et al (2006) Prognostic value of quantitative liver function tests in viral cirrhosis: a prospective study. Eur J Gastroenterol Hepatol 18: 713-720
27. Armuzzi A, Candelli M, Zocco MA, Andreoli A, De Lorenzo A, Nista EC, Miele L, et al (2002) Review article: breath testing for human liver function assessment. Aliment Pharmacol Ther 16: 1977-1996
28. Di Campli C, Angelini G, Armuzzi A, Nardo B, Zocco MA, Candelli M, Santoliquido A, et al (2003) Quantitative evaluation of liver function by the methionine and aminopyrine breath tests in the early stages of liver transplantation. Eur J Gastroenterol Hepatol 15: 727-732
29. Giannini EG, Fasoli A, Borro P, Botta F, Malfatti F, Fumagalli A, Testa E, et al (2005) 13C-galactose breath test and 13C-aminopyrine breath test for the study of liver function in chronic liver disease. Clin Gastroenterol Hepatol 3: 279-285
30. Ishii T, Furube M, Hirano S, Takatori K, Iida K, Kajiwara M (2001) Evaluation of 13C-phenylalanine and 13C-tyrosine breath tests for the measurement of hepatocyte functional capacity in patients with liver cirrhosis. Chem Pharm Bull (Tokyo) 49: 1507-1511
31. Perri F, Marras RM, Ricciardi R, Quitadamo M, Andriulli A (2004) 13C-breath tests in hepatology (cytosolic liver function). Eur Rev Med Pharmacol Sci 8: 47-49
32. Petrolati A, Festi D, De Berardinis G, Colaiocco-Ferrante L, Di Paolo D, Tisone G, Angelico M (2003) 13C-methacetin breath test for monitoring hepatic function in cirrhotic patients before and after liver transplantation. Aliment Pharmacol Ther 18: 785-790
33. Hsieh CB, Chen CJ, Chen TW, Yu JC, Shen KL, Chang TM, Liu YC (2004) Accuracy of indocyanine green pulse spectrophotometry clearance test for liver function prediction in transplanted patients. World J Gastroenterol 10: 2394-2396
34. O'Keefe SJ, Abraham R, El-Zayadi A, Marshall W, Davis M, Williams R (1981) Increased plasma tyrosine concentrations in patients with cirrhosis and fulminant hepatic failure associated with increased plasma tyrosine flux and reduced hepatic oxidation capacity. Gastroenterology 81: 1017-1024
35. Zello GA, Pencharz PB, Ball RO (1990) Phenylalanine flux, oxidation, and conversion to tyrosine in humans studied with L-[1-13C]phenylalanine. Am J Physiol 259: E835-E843
36. Fath JJ, Ascher NL, Konstantinides FN, Bloomer J, Sharp H, Najarian JS, Cerra FB (1984) Metabolism during hepatic transplantation: indicators of allograft function. Surgery 96: 664-674
37. Hadengue A, Lebrec D, Moreau R, Sogni P, Durand F, Gaudin C, Bernuau J, et al (1993) Persistence of systemic and splanchnic hyperkinetic circulation in liver transplant patients. Hepatology 17: 175-178