Synthesis of deuterated naproxens

Journal of Labelled Compounds and Radiopharmaceuticals

Volumn 50, Issue 14, 2007, Pages 1272-1275

  Gannett, Peter M ^a   Miller, Laura ^a   Daft, Jonathan ^a   Locuson, Charles ^b   Tracy, Timothy S ^b  

^a WEST VIRGINIA UNIVERSITY   (United States)

^b UNIVERSITY OF MINNESOTA   (United States)

Author keywords

Deuterated; Naproxen; Synthesis

Indexed keywords

DEUTERIUM; SATURATED FATTY ACIDS;

ATYPICALS; CYTOCHROMES P450; DEUTERATED; METHOXY; METHOXY GROUP; NAPROXENS; PROPANOIC ACID;

PROPIONIC ACID;

2 (6 HYDROXY 2 NAPHTHYL)PROPANOIC ACID; 2 (6 METHOXY 2 NAPHTHYL)PROPANOIC ACID; 2 [6 (1,4,7) 2 NAPHTHYL]PROPANOIC ACID D3 2; 2 [6 HYDROXY(1,4,7) 2 NAPHTHYL]PROPANOIC ACID D3 2; 2 [6 [METHYLOXY] 2 NAPHTHYL]PROPANOIC ACID D3 2; 2 [6 [METHYLOXY](1,4,7) 2 NAPHTHYL]PROPANOIC ACID D3 2; CYTOCHROME P450 2C9; DEUTERIUM; MTHYL 2 (6 METHOXY 2 NAPHTHYL)PROPANOATE; NAPROXEN DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; DRUG STRUCTURE; DRUG SYNTHESIS; ISOTOPE LABELING;

EID: 38949100762     PISSN: 03624803     EISSN: 10991344     Source Type: Journal    
DOI: 10.1002/jlcr.1451     Document Type: Article

References (8)

1. Williams PA, Cosme J, Vinkovic DM, Ward A, Angove HC, Day PJ, Vonrhein C, Tickle IJ, Jhoti H. Science 2004; 305: 683-686.
2. Rettie A, Jones JP. Annu Rev Pharmacol Toxicol 2005; 45: 477-494.
3. Hutzler JM, Kolwankar D, Hummel MA, Tracy TS. Drug Metab Dispos 2002; 30: 1194-1200.
4. Locuson CW, Gannett PM, Tracy TS. Arch Biochem Biophys 2006; 449: 115-129.
5. Rock DA, Perkins BNS, Wahlstrom J, Jones JP. Arch Biochem Biophys 2003; 416: 9-16.
6. Hafferl W, Hary A. J Label Compd Radiopharm 1973; 9: 293-300.
7. Yavorsky PM, Gorin E. J Am Chem Soc 1962; 84: 1071-1072.
8. Parker D. Chem Rev 1991; 91: 1441-1457.