Evaluation of acute and sub-chronic toxicity of Semelil (ANGIPARS™), a new phytotherapeutic drug for wound healing in rodents

Daru

Volumn 16, Issue SUPPL. 1, 2008, Pages 7-14

  Abdollahi, M ^a   Farzamfar, B ^b   Salari, P ^a   Khorram Khorshid, H R ^c   Larijani, B ^d   Farhadi, M ^e   Madani, S H ^f  

^a TEHRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b PASTEUR INSTITUTE OF IRAN   (Iran)

^c UNIVERSITY OF SOCIAL WELFARE AND REHABILITATION SCIENCES   (Iran)

^d TEHRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^e IRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^f Rabe Rashidi Institute Iran   (Iran)

Author keywords

ANGIPARS ; LD50; Preclinical trials; Rodents; Semelil; Toxicity

Indexed keywords

ALANINE AMINOTRANSFERASE; ALKALINE PHOSPHATASE; ANGIPARS; ASPARTATE AMINOTRANSFERASE; HERBACEOUS AGENT; LACTATE DEHYDROGENASE; SEMELIL; UNCLASSIFIED DRUG;

ACUTE TOXICITY; ANESTHESIA; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BEHAVIOR CHANGE; BLOOD ANALYSIS; CHRONIC TOXICITY; CONTROLLED STUDY; DEPRESSION; DRUG EFFECT; DRUG MONITORING; DRUG SAFETY; ENZYME ACTIVITY; FEMALE; HISTOPATHOLOGY; LD 50; MALE; MOUSE; NONHUMAN; RAT; SLEEP; TOXICITY TESTING; WOUND HEALING;

EID: 38949091734     PISSN: 15608115     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (15)

1. Reiber GE, Vileikyte L, Boyko EJ, del Aguila M, Smith DG, Lavery LA, Boulton AJ. Casual pathways for incident lower-extremity ulcers in patients with diabetes from two settings. Diabetes Care 1999; 22: 157-62.
2. Pecoraro RE, Reiber GE, Burgess EM. Pathways to diabetic limb amputation. Basis for prevention. Diabetes Care 1990; 13: 513-21.
3. th Camillo Golgi lecture. Diabetologia 2004; 47: 1343-53.
4. Reiber GE, Pecoraro RE, Koepsell TD. Risk factors for amputation in patients with diabetes mellitus. A case-control study. Ann Intern Med 1992; 117: 97-105.
5. Morris AD, McAlpine R, Steinke D, et al. Diabetes and lower-limb amputations in the community. A retrospective cohort study. DARTS/MEMO Collaboration. Diabetes Audit and Research in Tay-side Scotland/Medicines Monitoring Unit. Diabetes Care 1998; 21: 738-43.
6. Siitonen OI, Niskanen LK, Laakso M, Siitonen JT, Pyorala K. Lower-extremity amputations in diabetic and nondiabetic patients. A population-based study in eastern Finland. Diabetes Care 1993; 16: 16-20.
7. Consoli A. Chronic venous insufficiency: an open trial of FLEBS Crema. Minerva Cardioangiol. 2003 Aug; 51:411-6.
8. Plesca-Manea L, Pârvu AE, Pârvu M, Taǎmas M, Buia R. Effects of Melilotus officinalis on acute inflammation. Phytotherapy. Res. 2002; 16: 316-19.
9. Vettorello G, Cerreta G, Derwish A, Cataldi A, Schettino A, Occhionorelli S, Donini I. Contribution of a combination of alpha and beta benzopyrones, flavonoids and natural terpenes in the treatment of lymphedema of the lower limbs at the 2d stage of the surgical classification. Minerva Cardioangiol. 1996; 44: 447-55.
10. Deichmann, W. B. and LeBlanc, T. J.: Determination of the approximate lethal dose with about six animals. J. Industrial Hygiene and Toxicology 25: 415-417, 1943.
11. Litchfield JT, Wilcoxon FA, A simplified method of evaluating dose-effect experiments. J. Pharmacol. Exp. Ther. 1949, 96:99-113.
12. Dietrich, L. A new approach to practical acute toxicity. Arch. Toxicol. 1983; 54: 275-289.
13. Sorrentinoa L, Capassob A, Schmidt M. Safety of ethanolic kava extract: Results of a study of chronic toxicity in rats. Phytomedicine 2006;13: 542-549.
14. Atsuya T, Kiyoshi S, Minoru S, Jun K. Acute, subchronic and chronic toxicity studies of a synthetic antioxidant 2,2′-Isobutylidenebis(4,6- dimethylphenol) in rats. J. Toxicol. Sci. 2005; 30(4):275-285.
15. Rahimi R, Nikfar S, Larijani B, Abdollahi M. A review on the role of antioxidants in the management of diabetes and its complications. Biomed Pharmacother. 2005; 59(7):365-73.