Carrier effects on antitumor activity and neurotoxicity of AZ10992, a paclitaxel-carboxymethyl dextran conjugate, in a mouse model

Biological and Pharmaceutical Bulletin

Volumn 31, Issue 2, 2008, Pages 223-230

  Sugahara, Shu Ichi ^a   Kajiki, Masahiro ^a   Kuriyama, Hiroshi ^a   Kobayashi, To Ru ^a  

^a ASAHI KASEI CORPORATION   (Japan)

Author keywords

Antitumor effect; Neurotoxicity; Paclitaxel delivery system; Polymer drug conjugate

Indexed keywords

ANTINEOPLASTIC AGENT; AZ 10992; CARBOXYMETHYLDEXTRAN; PACLITAXEL; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CONTROLLED STUDY; DRUG CONJUGATION; DRUG EFFECT; DRUG STRUCTURE; FEMALE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MOUSE; NEUROTOXICITY; NONHUMAN; PHYSICAL CHEMISTRY;

ANIMALS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; CHEMISTRY, PHYSICAL; DEXTRANS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG CARRIERS; FEMALE; MALE; MICE; MICE, INBRED BALB C; MOLECULAR WEIGHT; NEUROTOXICITY SYNDROMES; PACLITAXEL; PHYSICOCHEMICAL PHENOMENA; RATS; RATS, WISTAR; SCIATIC NERVE; TISSUE DISTRIBUTION;

EID: 38849205364     PISSN: 09186158     EISSN: 13475215     Source Type: Journal    
DOI: 10.1248/bpb.31.223     Document Type: Article

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