Evidence for genetic regulation of endothelial progenitor cells and their role as biological markers of atherosclerotic susceptibility

European Heart Journal

Volumn 29, Issue 3, 2008, Pages 332-338

  Whittaker, Andrew ^a   Moore, Jasbir S ^a   Vasa Nicotera, Mariuca ^a   Stevens, Suzanne ^a   Samani, Nilesh J ^a  

^a UNIVERSITY OF LEICESTER   (United Kingdom)

Author keywords

Atherosclerosis; Biological markers; Coronary artery disease; Endothelial progenitor cells; Heritability

Indexed keywords

BIOLOGICAL MARKER; CD133 ANTIGEN; CD34 ANTIGEN; ENDOTHELIAL CELL GROWTH FACTOR; VASCULOTROPIN RECEPTOR 2;

ADULT; ARTICLE; ATHEROSCLEROSIS; CARDIOVASCULAR RISK; CELL COUNT; CELL CULTURE; CELL FUNCTION; CELL GROWTH; CELL MIGRATION; CLINICAL ARTICLE; CONTROLLED STUDY; CORONARY ARTERY DISEASE; CORRELATION ANALYSIS; DEMOGRAPHY; ENDOTHELIAL PROGENITOR CELL; ENDOTHELIUM CELL; FEMALE; GENETIC REGULATION; HUMAN; MALE; PARENT; PRIORITY JOURNAL; PROGENY; STATISTICAL SIGNIFICANCE; STEM CELL;

ADULT; ATHEROSCLEROSIS; BIOLOGICAL MARKERS; CASE-CONTROL STUDIES; CELL COUNT; CELL MOVEMENT; CELLS, CULTURED; CORONARY ARTERY DISEASE; ENDOTHELIAL CELLS; ENDOTHELIUM, VASCULAR; FEMALE; GENETIC PREDISPOSITION TO DISEASE; HEMATOPOIETIC STEM CELLS; HUMANS; MALE; MIDDLE AGED; PREDICTIVE VALUE OF TESTS; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 38849201040     PISSN: 0195668X     EISSN: 15229645     Source Type: Journal    
DOI: 10.1093/eurheartj/ehm602     Document Type: Article

References (27)

1. Ross R. Atherosclerosis - an inflammatory disease. N Engl J Med 1999;340:115-126.
2. Libby P. Inflammation in atherosclerosis. Nature 2002;420:868-874.
3. Watkins H, Farrall M. Genetic susceptibility to coronary artery disease: from promise to progress. Nat Rev Genet 2006;7:163-173.
4. Dimmeler S, Zeiher AM. Vascular repair by circulating endothelial progenitor cells: the missing link in atherosclerosis? J Mol Med 2004;82:671-677.
5. Carmeliet P. Angiogenesis in health and disease. Nat Med 2003;9:653-660.
6. Asahara T, Murohara T, Sullivan A, Silver M, van der Zee R, Li T, Witzenbichler B, Schatteman G, Isner JM. Isolation of putative progenitor endothelial cells for angiogenesis. Science 1997;275:964-967.
7. Hristov M,Weber C. Endothelial progenitor cells: characterisation, pathophysiology, and possible clinical relevance. J Cell Mol Med 2004;8:498-508.
8. Vasa M, Fichtlscherer S, Aicher A, Adler K, Urbich C, Martin H, Zeiher AM, Dimmeler S. Number and migratory activity of circulating endothelial progenitor cells inversely correlate with risk factors for coronary artery disease. Circ Res 2001;89:E1-E7.
9. Gehling UM, Ergun S, Schumacher U, Wagener C, Pantel K, Otte M, Schuch G, Schafhausen P, Mende T, Kilic N, Kluge K, Schafer B, Hossfeld DK, Fiedler W. In vitro differentiation of endothelial cells from AC133-positive progenitor cells. Blood 2000;95:3106-3112.
10. Peichev M, Naiyer AJ, Pereira D, Zhu Z, Lane WJ, Williams M, Oz MC, Hicklin DJ, Witte L, Moore MA, Rafii S. Expression of VEGFR-2 and AC133 by circulating human CD34(+) cells identifies a population of functional endothelial precursors. Blood 2000;95:952-958.
11. Hristov M, Erl W, Weber PC. Endothelial progenitor cells: mobilisation, differentiation and homing. Arterioscler Thromb Vasc Biol 2003;23:1185-1189.
12. Hill JM, Zalos G, Halcox JP, Schenke WH, Waclawiw MA, Quyyumi AA, Finkel T. Circulating endothelial progenitor cells, vascular function, and cardiovascular risk. N Engl J Med 2003;348:593-600.
13. Eizawa T, Ikeda U, Murakami Y, Matsui K, Yoshioka T, Takahashi M, Muroi K, Shimada K. Decrease in circulating endothelial progenitor cells in patients with stable coronary artery disease. Heart 2004;90:685-686.
14. Loomans CJ, de Koning EJ, Staal FJ, Rookmaaker MB, Verseyden C, de Boer HC, Verhaar MC, Braam B, Rabelink TJ, van Zonneveld AJ. Endothelial progenitor cell dysfunction: a novel concept in the pathogenesis of vascular complications of type 1 diabetes. Diabetes 2004;53:195-199.
15. Tepper OM, Galiano RD, Capla JM, Kalka C, Gagne PJ, Jacobowitz GR, Levine JP, Gurtner GC. Human endothelial progenitor cells from type II diabetics exhibit impaired proliferation, adhesion, and incorporation into vascular structures. Circulation 2002;106:2781-2786.
16. Werner N, Kosiol S, Schiegl T, Ahlers P, Walenta K, Link A, Bohm M, Nickenig G. Circulating endothelial progenitor cells and cardiovascular outcomes. N Engl J Med 2005;353:999-1007.
17. Tobin MD, Raleigh SM, Newhouse S, Braund P, Bodycote C, Ogleby J, Cross D, Gracey J, Hayes S, Smith T, Ridge C, Caulfield M, Sheehan NA, Munroe PB, Burton PR, Samani NJ. Association of WNK1 gene polymorphisms and haplotypes with ambulatory blood pressure in the general population. Circulation 2005;112:3423-3429.
18. Vasa M, Fichtlscherer S, Adler K, Aicher A, Martin H, Zeiher AM, Dimmeler S. Increase in circulating endothelial progenitor cells by statin therapy in patients with stable coronary artery disease. Circulation 2001;103:2885-2890.
19. Dimmeler S, Aicher A, Vasa M, Mildner-Rihm C, Adler K, Tiemann M, Rutten H, Fichtlscherer S, Martin H, Zeiher AM. HMG-CoA reductase inhibitors (statins) increase endothelial progenitor cells via the PI 3-kinase/Akt pathway. J Clin Invest 2001;108:391-397.
20. Llevadot J, Murasawa S, Kureishi Y, Uchida S, Masuda H, Kawamoto A, Walsh K, Isner JM, Asahara T. HMG-CoA reductase inhibitor mobilizes bone marrow-derived endothelial progenitor cells. J Clin Invest 2001;108:399-405.
21. Clarkson P, Celermajer DS, Powe AJ, Donald AE, Henry RM, Deanfield JE. Endothelium-dependent dilatation is impaired in young healthy subjects with a family history of premature coronary artery disease. Circulation 1997;96:3378-3383.
22. Blann AD. Plasma von Willebrand factor, thrombosis, and the endothelium: the first 30 years. Thromb Haemost 2006;95:49-55.
23. Powell TM, Paul JD, Hill JM, Thompson M, Benjamin M, Rodrigo M, McCoy JP, Read EJ, Khuu HM, Leitman SF, Finkel T, Cannon RO. Granulocyte colony-stimulating factor mobilises functional endothelial progenitor cells in patients with coronary artery disease. Arterioscler Thromb Vasc Biol 2005;25:296-301.
24. Walenta K, Friedrich EB, Sehnert F, Werner N, Nickenig G. In vitro differentiation characteristics of cultured human mononuclear cells - implications for endothelial progenitor cell biology. Biochem Biophys Res Commun 2005;333:476-482.
25. Urbich C, Dimmeler S. Endothelial progenitor cells: characterisation and role in vascular biology. Circ Res 2004;95:343-353.
26. Lapidot T, Petit I. Current understanding of stem cell mobilisation: the roles of chemokines, proteolytic enzymes, adhesion molecules, cytokines, and stromal cells. Exp Hematol 2002;30:973-981.
27. Kalka C, Masuda H, Takahashi T, Gordon R, Tepper O, Gravereaux E, Pieczek A, Iwaguro H, Hayashi SI, Isner JM, Asahara T. Vascular endothelial growth factor (165) gene transfer augments circulating endothelial progenitor cells in human subjects. Circ Res 2000;86:1198-1202.