Structural finding of R/S-3,4-dihydro-2,2-dimethyl-6-halo-4-(substituted phenylaminocarbonylamino)-2H-1-benzopyrans as selective pancreatic β-cells KATP-pβ channel openers

Canadian Journal of Chemistry

Volumn 85, Issue 12, 2007, Pages 1053-1063

  Alam, Sk Mahasin ^a   Samanta, Soma ^a   Halder, Amit Kumar ^a   Basu, Soumya ^a   Jha, Tarun ^a  

^a JADAVPUR UNIVERSITY   (India)

Author keywords

Benzopyran derivatives; PCRA; PLS; Potassium channel openers; QSAR

Indexed keywords

BIOACTIVITY; INSULIN; LEAST SQUARES APPROXIMATIONS; LINEAR REGRESSION; MATHEMATICAL MODELS; TISSUE;

BENZOPYRAN DERIVATIVES; PCRA; PLS; POTASSIUM CHANNEL OPENERS; QSAR;

BENZENE;

EID: 38849197929     PISSN: 00084042     EISSN: None     Source Type: Journal    
DOI: 10.1139/V07-127     Document Type: Article

References (30)

1. B. Alberts, A. Johnson, J. Lewis, M. Raff, K. Roberts, and P. Walter. Molecular Biology of the Cell. 4th ed. Garland Science, NY 2002. p. 632.
2. T. Nogrady. Medicinal chemistry: A biochemical approach,. 2nd ed. Oxford University Press, NY 2004. pp. 344-345.
3. D.J. Triggle. In Textbook of drug design and discovery. 3rd ed. Edited by P. Krogsgaard-Larsen, T. Liljefors, and U. Madsen. Taylor & Francis, NY. 2002. pp. 187-200.
4. J.R. Fozard and P.W. Manley. Prog. Respir. Res. 31, 77 (2001).
5. M. Schwanstecher, C. Sieverding, H. Dorschner, I. Gross, L. Aguilar-Bryan, C. Schwanstecher, and J. Bryan. EMBO J. 17, 5529 (1998).
6. H.P. Rang, M.M. Dale, J.M. Ritter, and P.K. Moore. Pharmacology. 5th ed. Churchill Livingstone, Edinburgh, Scotland. 2003. p. 294.
7. K. Lawson. Pharmacol. Ther. 70, 39 (1996).
8. S. Sebille, D. Gall, P. de Tullio, X. Florence, P. Lebrun, and B. Pirotte. J. Med. Chem. 49, 4690 (2006).
9. S. Samanta, B. Debnath, S. Gayen, B. Ghosh, K. Srikanth, and T. Jha. Farmaco, 60, 818 (2005).
10. B. Debnath, S. Gayen, S. Samanta, A. Basu, B. Ghosh, and T. Jha. Ind. J. Chem. A 45A, 93 (2006).
11. A. Basu, S. Gayen, S. Samanta, P. Panda, K. Srikanth, and T. Jha. Can. J. Chem. 84, 458 (2006).
12. S. Samanta, Sk.M. Alam, P. Panda, and T. Jha. Internet Electron J. Mol. Des. 6, 503 (2006).
13. S. Samanta, B. Debnath, A. Basu, S. Gayen, K. Srikanth, and T. Jha. Eur. J. Med. Chem. 41, 1190 (2006).
14. T. Jha, B. Debnath, S. Samanta, and A. U. De. Internet. Electron. J. Mol. Des. 2, 539 (2003) [online]. Available from http://www.biochempress.com.
15. S. Gayen, B. Debnath, and T. Jha. Internet Electron. J. Mol. Des. 3, 771 (2004) [online]. Available from. http://www.biochempress.com.
16. S. Gayen, B. Debnath, A. Basu, S. Samanta, B. Ghosh, S.K. Naskar, and T. Jha. Internet Electron. J. Mol. Des. 4, 210 (2005) [online]. Available from http://www.biochempress.com.
17. B. Debnath, S. Samanta, S. Gayen, A. Basu, B. Ghosh, and T. Jha. Internet Electron. J. Mol. Des. 4, 393 (2005) [online]. Available from http://www.biochempress.com.
18. S. Gayen, B. Debnath, S. Samanta, B. Ghosh, A. Basu, and T. Jha. Internet Electron. J. Mol. Des. 4, 556 (2005) [online]. Available from http://www.biochempress.com.
19. H. Hall, B. Mohney, and L. B. Kier. Quant. Struct.-Act. Relat. 10, 43 (1991).
20. C. de Gregorio, L.B. Kier, and L.H. Hall. J. Comput. Aid. Mol. Des. 12, 557 (1998).
21. R. Carrasco, J.A. Padron, and J. Galvez. J. Pharm. Pharmaceut. Sci. 7, 19 (2004).
22. O. Ivanciuc. Topological indices. In Handbook of chemoinformatics. Edited by J. Gasteiger. Wiley-VCH, Weinheim, Germany. 2003. pp. 981-1003.
23. Mouse: A computer program developed by S.K. Naskar of the Department of Computer Science and Engineering, Jadavpur University, Kolkata, India, and B. Debnath for the calculation of the ETSA Index [computer program].
24. Chem 3D Pro Version 5.0 and Chem Draw Ultra Version 5.0 are programs CambridgeSoft Corporation, Cambridge, MA [computer program].
25. G.W. Snedecor and W.G. Cochran. Statistical methods. 6th ed. Oxford & IBH. New Delhi, India. 1967. pp. 381-418.
26. R. Franke. Theoretical drug design methods. Elsevier. Amsterdam. 1984. p 184-195.
27. J.T. Leonard and K. Roy. Bioorg. Med. Chem. Lett. 16, 4467 (2006).
28. J.T. Leonard and K. Roy. Bioorg. Med. Chem. 14, 1039 (2006).
29. K. Roy, I. Sanyal, and P. P. Roy. SAR QSAR Environ. Res. 17, 563 (2006).
30. S. Wold and L. Eriksson. In Chemometric methods in molecular design. Edited by H. Van de Waterbeemd. Wiley-VCH, Weinheim, Germany. 1995. pp. 312-317.