Radiotherapy for Rectal Cancer Is Associated With Reduced Serum Testosterone and Increased FSH and LH

International Journal of Radiation Oncology Biology Physics

Volumn 70, Issue 3, 2008, Pages 722-727

  Bruheim, Kjersti ^a   Svartberg, Johan ^b,c   Carlsen, Erik ^a   Dueland, Svein ^d   Haug, Egil ^e   Skovlund, Eva ^f   Tveit, Kjell Magne ^a   Guren, Marianne G ^a  

^a ULLEVÅL UNIVERSITY HOSPITAL   (Norway)

^b UNIVERSITY OF TROMSØ   (Norway)

^c UNIVERSITY HOSPITAL OF NORTH NORWAY   (Norway)

^d OSLO UNIVERSITY HOSPITAL   (Norway)

^e AKER UNIVERSITY HOSPITAL   (Norway)

^f UNIVERSITY OF OSLO   (Norway)

Author keywords

Late effects; Radiotherapy; Rectal cancer; Testosterone; Toxicity

Indexed keywords

BODY FLUIDS; HORMONES; RADIOTHERAPY; TOXICITY;

LATE EFFECTS; RECTAL CANCER; TESTOSTERONE;

ONCOLOGY;

FLUOROURACIL; FOLINIC ACID; FOLLITROPIN; GONADOTROPIN; LUTEINIZING HORMONE; SEX HORMONE BINDING GLOBULIN; TESTOSTERONE;

AGED; ARTICLE; BLOOD ANALYSIS; CANCER PATIENT; CANCER RADIOTHERAPY; CANCER REGISTRY; COMPARATIVE STUDY; CONTROLLED STUDY; FOLLITROPIN BLOOD LEVEL; GONADOTROPIN BLOOD LEVEL; HUMAN; LUTEINIZING HORMONE BLOOD LEVEL; MAJOR CLINICAL STUDY; MALE; PELVIS; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; RECTUM CANCER; SEX HORMONE DETERMINATION; TESTIS DISEASE; TESTOSTERONE BLOOD LEVEL; TESTOSTERONE SYNTHESIS;

AGED; AGED, 80 AND OVER; CASE-CONTROL STUDIES; FOLLICLE STIMULATING HORMONE; HUMANS; LUTEINIZING HORMONE; MALE; RADIOTHERAPY, ADJUVANT; RECTAL NEOPLASMS; SCATTERING, RADIATION; SEX HORMONE-BINDING GLOBULIN; TESTIS; TESTOSTERONE;

EID: 38849179514     PISSN: 03603016     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijrobp.2007.10.043     Document Type: Article

References (26)

1. Kapiteijn E., Marijnen C.A.M., Nagtegaal I.D., et al. Preoperative radiotherapy combined with total mesorectal excision for resectable rectal cancer. N Engl J Med 345 (2001) 638-646
2. Sauer R., Becker H., Hohenberger W., et al. Preoperative versus postoperative chemoradiotherapy for rectal cancer. N Engl J Med 351 (2004) 1731-1740
3. Ortholan C., Francois E., Thomas O., et al. Role of radiotherapy with surgery for T3 and resectable T4 rectal cancer: Evidence from randomized trials. Dis Colon Rectum 49 (2006) 302-310
4. Hansen M.H., Kjaeve J., Revhaug A., et al. Impact of radiotherapy on local recurrence of rectal cancer in Norway. Br J Surg 94 (2007) 113-118
5. Endreseth B.H., Romundstad P., Myrvold H.E., et al. Rectal cancer in the young patient. Dis Colon Rectum 49 (2006) 993-1001
6. Howell S., and Shalet S. Gonadal damage from chemotherapy and radiotherapy. Endocrinol Metab Clin North Am 27 (1998) 927-943
7. Piroth M.D., Hensley F., Wannenmacher M., et al. Male gonadal dose in adjuvant 3-d-pelvic irradiation after anterior resection of rectal cancer. Influence to fertility. [in German]. Strahlenther Onkol 179 (2003) 754-759
8. Izard M.A. Leydig cell function and radiation: A review of the literature. Radiother Oncol 34 (1995) 1-8
9. Shores M.M., Sloan K.L., Matsumoto A.M., et al. Increased incidence of diagnosed depressive illness in hypogonadal older men. Arch Gen Psychiatry 61 (2004) 162-167
10. Svartberg J., Jenssen T., Sundsfjord J., et al. The associations of endogenous testosterone and sex hormone-binding globulin with glycosylated hemoglobin levels, in community dwelling men. The Tromsø Study. Diabetes Metab 30 (2004) 29-34
11. Svartberg J., von Mülen D., Sundsfjord J., et al. Waist circumference and testosterone levels in community dwelling men. The Tromsø study. Eur J Epidemiol 19 (2004) 657-663
12. Svartberg J., von Mülen D., Schirmer H., et al. Association of endogenous testosterone with blood pressure and left ventricular mass in men. The Tromsø Study. Eur J Endocrinol 150 (2004) 65-71
13. Dueland S., Guren M.G., Olsen D.R., et al. Radiation therapy induced changes in male sex hormone levels in rectal cancer patients. Radiother Oncol 68 (2003) 249-253
14. Hermann R.M., Henkel K., Christiansen H., et al. Testicular dose and hormonal changes after radiotherapy of rectal cancer. Radiother Oncol 75 (2005) 83-88
15. Mazonakis M., Damilakis J., Varveris H., et al. Radiation dose to testes and risk of infertility from radiotherapy for rectal cancer. Oncol Rep 15 (2006) 729-733
16. Shapiro E., Kinsella T.J., Makuch R.W., et al. Effects of fractionated irradiation of endocrine aspects of testicular function. J Clin Oncol 3 (1985) 1232-1239
17. Vermeulen A., Verdonck L., and Kaufman J.M. A critical evaluation of simple methods for the estimation of free testosterone in serum. J Clin Endocrinol Metab 84 (1999) 3666-3672
18. Tveit K.M., Guldvog I., Hagen S., et al. Randomized controlled trial of postoperative radiotherapy and short-term time-scheduled 5-fluorouracil against surgery alone in the treatment of Dukes B and C rectal cancer. Norwegian Adjuvant Rectal Cancer Project Group. Br J Surg 84 (1997) 1130-1135
19. Giagulli V.A., and V. Leydig cell function in infertile men with idiopathic oligospermic infertility. J Clin Endocrinol Metab 66 (1988) 62-67
20. Glass A.R., and Vigersky R.A. Leydig cell function in idiopathic oligospermia. Fertil Steril 34 (1980) 144-148
21. Morley J.E., Patrick P., and Perry III H.M. Evaluation of assays available to measure free testosterone. Metabolism 51 (2002) 554-559
22. Vermeulen A., Kaufman J.M., and Giagulli V.A. Influence of some biological indexes on sex hormone-binding globulin and androgen levels in aging or obese males. J Clin Endocrinol Metab 81 (1996) 1821-1826
23. Kinsella T.J. Effects of radiation therapy and chemotherapy on testicular function. Prog Clin Biol Res 302 (1989) 157-171
24. Svartberg J., and Jorde R. Endogenous testosterone levels and smoking in men. The fifth Tromsø study. Int J Androl 30 (2007) 137-143
25. Amies C.J., Mameghan H., Rose A., et al. Testicular doses in definitive radiation therapy for localized prostate cancer. Int J Radiat Oncol Biol Phys 32 (1995) 839-846
26. Budgell G.J., Cowan R.A., and Hounsell A.R. Prediction of scattered dose to the testes in abdominopelvic radiotherapy. Clin Oncol 13 (2001) 120-125