Pathological anxiety in animals

Veterinary Journal

Volumn 175, Issue 1, 2008, Pages 18-26

  Ohl, Frauke ^a   Arndt, Saskia S ^a   van der Staay, F Josef ^b  

^a UTRECHT UNIVERSITY   (Netherlands)

^b WAGENINGEN UNIVERSITY   (Netherlands)

Author keywords

Behavioural inhibition system; Biological relevance; Husbandry animals; Pathological anxiety

Indexed keywords

ANIMAL BEHAVIOR; ANIMAL WELFARE; ANXIETY DISORDER; AVOIDANCE BEHAVIOR; BEHAVIOR DISORDER; BREEDING METHOD; COPING BEHAVIOR; DIAGNOSTIC AND STATISTICAL MANUAL OF MENTAL DISORDERS; DIAGNOSTIC PROCEDURE; DOMESTIC ANIMAL; EMOTIONALITY; ENVIRONMENTAL FACTOR; EXPERIMENTAL ANIMAL; EXPLORATORY BEHAVIOR; FARM ANIMAL; GENETIC SELECTION; NEUROPHYSIOLOGY; NONHUMAN; QUALITY OF LIFE; REVIEW; RISK ASSESSMENT; SEPARATION ANXIETY; SOCIAL ASPECT; SPECIES DIFFERENCE;

ANIMAL HUSBANDRY; ANIMALS; ANXIETY DISORDERS; BEHAVIOR, ANIMAL; PEDIGREE;

ANIMALIA;

EID: 38849173810     PISSN: 10900233     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tvjl.2006.12.013     Document Type: Review

References (78)

1. Appleby D., and Pluijmakers J. Separation anxiety in dogs: the function of homeostasis in its development and treatment. Veterinary Clinics of North America: Small Animal Practice 33 (2003) 321-344
2. Barnett S.A. The Rat: A Study in Behavior (1963), Aldine Publishing Co, Chicago, IL
3. Battaglia M., and Ogliari A. Anxiety and panic: from human studies to animal research and back. Neuroscience and Biobehavioral Reviews 29 (2005) 169-179
4. Belzung C. Measuring rodent exploratory behavior. In: Crusio W.E., and Gerlai T.T. (Eds). Handbook of Molecular Genetics for Brain and Behavior Research (1999), Elsevier, New York 77-99
5. Belzung C., and Berton F. Further pharmacological validation of the BALB/c neophobia in the free exploratory paradigm as an animal model of trait anxiety. Behavioural Pharmacology 8 (1997) 541-548
6. Belzung C., and Le Pape G. Comparison of different behavioral test situations used in psychopharmacology for measurement of anxiety. Physiology and Behavior 56 (1994) 623-628
7. Beuzen A., and Belzung C. Link between emotional memory and anxiety states: a study by principal component analysis. Physiology and Behavior 58 (1995) 111-118
8. Blanchard R.J., and Blanchard D.C. Attack and defense in rodents as ethoexperimental models for the study of emotion. Progress in Neuro-Psychopharmacology and Biological Psychiatry 13 Suppl. (1989) S3-S14
9. Blanchard R.J., Yudko E.B., Rodgers R.J., and Blanchard D.C. Defense system psychopharmacology: an ethological approach to the pharmacology of fear and anxiety. Behavioural Brain Research 58 (1993) 155-165
10. Boissy A. Fear and fearfulness in animals. The Quarterly Review of Biology 70 (1995) 165-191
11. Brackman J. Engineering pedigreed dogs: a semiotic perspective. Semiotica 133 (2001) 141-155
12. Cahill L., and McGaugh J.L. Mechanisms of emotional arousal and lasting declarative memory. Trends in Neurosciences 21 (1998) 294-299
13. Campbell T., Lin S., deVries C., and Lambert K. Coping strategies in male and female rats exposed to multiple stressors. Physiology and Behavior 78 (2003) 495-504
14. Charney D.S., and Drevets W.C. Neurobiological basis of anxiety disorders. In: Davis K.L., Charney D., Coyle J.T., and Nemeroff C. (Eds). Neuropsychopharmacology: The Fifth Generation of Progress (2002), American College of Neuropsychopharmacololgy 901-930 (Chapter 63)
15. Chatherall D.R. How fear differs from anxiety. Traumatology 9 (2003) 76-92
16. Clement Y., and Chapouthier G. Biological bases of anxiety. Neuroscience and Biobehavioral Reviews 22 (1998) 623-633
17. Clement Y., Calatayud F., and Belzung C. Genetic basis of anxiety-like behaviour: a critical review. Brain Research Bulletin 57 (2002) 57-71
18. Crawley J., and Goodwin F.K. Preliminary report of a simple animal behavior model for the anxiolytic effects of benzodiazepines. Pharmacology Biochemistry and Behavior 13 (1980) 167-170
19. Crusio WE. Genetic dissection of mouse exploratory behaviour. Behavioural Brain Research 125 (2001) 127-132
20. Cruz A.P., Frei F., and Graeff F.G. Ethopharmacological analysis of rat behavior on the elevated plus-maze. Pharmacology Biochemistry and Behavior 49 (1994) 171-176
21. Davis M. Are different parts of the extended amygdala involved in fear and anxiety?. Biological Psychiatry 44 (1998) 1239
22. Dirks A., Groenink L., Schipholt M.I., van der Gugten J., Hijzen T.H., Geyer M.A., and Olivier B. Reduced startle reactivity and plasticity in transgenic mice overexpressing corticotropin-releasing hormone. Biological Psychiatry 51 (2002) 583-590
23. DSM-IV. The Diagnostic and Statistical Manual of Mental Disorders. fourth ed. (1994), American Psychiatric Association
24. Eilam D., and Golani I. Home base behavior of rats (Rattus norvegicus) exploring a novel environment. Behavioural Brain Research 34 (1989) 199-211
25. Eilam D., and Golani I. Home base behavior in amphetamine-treated tame wild rats (Rattus norvegicus). Behavioural Brain Research 36 (1990) 161-170
26. Escorihuela R.M., Fernandez-Teruel A., Gil L., Aguilar R., Tobena A., and Driscoll P. Inbred Roman high- and low-avoidance rats: differences in anxiety, novelty-seeking, and shuttlebox-behavior. Behaviour and Physiology 67 (1999) 19-26
27. Friman P.C., Hayes S.C., and Wilson K.G. Why behavior analysts should study emotion: the example of anxiety. Journal of Applied Behavior Analysis 31 (1998) 137-156
28. Gershenfeld H.K., and Paul S.M. Mapping quantitative trait loci for fear-like behaviors in mice. Genomics 46 (1997) 1-8
29. Grandin T., and Deesing M.J. Genetics and the behavior of domestic animals. Behavioral Genetics and Animal Science (1998), Academic Press, San Diego (Chapter 1)
30. Gray T.S. Amygdaloid CRF pathways: Role in autonomic, neuroendocrine, and behavioral responses to stress. Annals of the New York Academy of Sciences 697 (1990) 53-60
31. Griebel G., Belzung C., Misslin R., and Vogel E. The free-exploratory paradigm: an effective method for measuring neophobic behaviour in mice and testing potential neophobia-reducing drugs. Behavioural Pharmacology 4 (1993) 637-644
32. Gross J.J. Emotion regulation: past, present, future. Cognition and Emotion 13 (1999) 551-573
33. Hall C.S. Emotional behavior in the rat. III. The relationship between emotionality and ambulatory activity. Journal of Comparative and Physiological Psychology 22 (1936) 345-352
34. Handley S.L., and Mithani S. Effects of alpha-adrenoceptor agonists and antagonists in a maze-exploration model of 'fear'-motivated behaviour. Naunyn-Schmiedeberg's Archives of Pharmacology 327 (1984) 1-5
35. Henn F.A., Johnson J., Edwards E., and Anderson D. Melancholia in rodents: neurobiology and pharmacology. Psychopharmacology Bulletin 21 (1985) 443-446
36. Hindmarch I. Cognition and anxiety: the cognitive effects of anti-anxiety medication. Acta Psychiatrica Scandinavica, Supplementum 393 (1998) 89-94
37. Ingram R.E., and Kendall P.C. The cognitive side of anxiety. Cognitive Therapy and Research 11 (1987) 523-536
38. Kanitz E., Tuchscherer M., Puppe B., Tuchscherer A., and Bernd Stabenow B. Consequences of repeated early isolation in domestic piglets (Sus scrofa) on their behavioural, neuroendocrine, and immunological responses. Brain, Behavior, and Immunity 18 (2004) 35-45
39. Kelley A.E. Locomotor activity and exploration. In: Sahgal A. (Ed). Behavioural Neuroscience: A Practical Approach (1993), Oxford University Press, Oxford 1-21
40. Koolhaas J.M., Korte S.M., de Boer S.F., van der Vegt B.J., van Reenen C.G., Hopster H., de Jong I.C., Ruis M.A.W., and Blokhuis H.J. Coping styles in animals: current status in behavior and stress-physiology. Neuroscience and Biobehavioral Reviews 23 (1999) 925-935
41. Landgraf R., and Wigger A. High vs low anxiety-related behavior in rats: an animal model of extreme anxiety traits. Behavior Genetics 32 (2002) 301-314
42. Lang P.J., Davis M., and Öhman A. Fear and anxiety: animal models and human cognitive psychophysiology. Journal of Affective Disorders 61 (2000) 137-159
43. Laycock S.R., and Bal R.O. Alleviation of hysteria in laying hens with dietary tryptophan. Canadian Journal of Veterinary Research 54 (1990) 291-295
44. Livesey P.J. Learning and Emotion: A Biological Synthesis (1986), Lawrence Erlbaum, Hillsdale, NJ
45. Marks I.M., and Nesse R.M. Fear and fitness: an evolutionary analysis of anxiety disorders. Ethology and Sociobiology 15 (1994) 247-261
46. McEwen B.S. Early life influences on life-long patterns of behaviour and health. Mental Retardation and Developmental Disabilities Research Reviews 9 (2003) 149-154
47. McGaugh J.L., Cahill L., and Roozendaal B. Involvement of the amygdala in memory storage: interaction with other brain systems. Proceedings of the National Academy of Sciences of the United States of America 93 (1996) 13508-13514
48. McNally R.J. Information-processing abnormalities in anxiety disorders: implications for cognitive neuroscience. Cognition and Emotion 12 (1998) 479-495
49. McNaughton N. Cognitive dysfunction resulting from hippocampal hyperactivity - a possible cause of anxiety disorder?. Pharmacology Biochemistry and Behavior 56 (1997) 603-611
50. McNaughton N., and Corr P.J. A two-dimensional neuropsychology of defense: fear/anxiety and defensive distance. Neuroscience and Biobehavioral Reviews 28 (2004) 285-305
51. McNaughton N., and Gray J.A. Anxiolytic action on the behavioural inhibition system implies multiple types of arousal to anxiety. Journal of Affective Disorders 61 (2000) 161-176
52. Muir W.M., and Craig J.V. Improving animal well-being through genetic selection. Poultry Science 77 (1998) 1781-1788
53. Nesse R.M. Proximate and evolutionary studies of anxiety, stress and depression: synergy at the interface. Neuroscience and Biobehavioral Reviews 23 (1999) 895-903
54. Ohl F. Animal models of anxiety. Handbook of Experimental Pharmacology 169 (2005) 35-69
55. Ohl F., Toschi N., Wigger A., Henniger M.S., and Landgraf R. Dimensions of emotionality in a rat model of innate anxiety. Behavioral Neuroscience 115 (2001) 429-436
56. Ohl F., Roedel A., Storch C., Holsboer F., and Landgraf R. Cognitive performance in rats differing in their inborn anxiety. Behavioral Neuroscience 116 (2002) 464-471
57. Ohl F., Roedel A., Binder E., and Holsboer F. Impact of high and low anxiety on cognitive performance in a modified hole board test in C57BL/6 and DBA/2 mice. The European Journal of Neuroscience 17 (2003) 128-136
58. Overall K.L. Natural animal models of human psychiatric disorders: assessment of mechanism and validity. Progress in Neuro-Psychopharmacology and Biological Psychiatry 24 (2000) 727-776
59. Overall K.L. Proceedings of the Dogs Trust Meeting on Advance in veterinary Behavioural medicine London; 4th-7th November 2004, Veterinary behavioural medicine: a roadmap for the 21st century. The Veterinary Journal 169 (2005) 130-143
60. Overmier J.B., and Seligman M.E. Effects of inescapable shock upon subsequent escape and avoidance responding. Journal of Comparative and Physiological Psychology 63 (1967) 28-33
61. Pellow S., Chopin P., File S.E., and Briley M. Validation of open:closed arm entries in an elevated plus-maze as a measure of anxiety in the rat. Journal of Neuroscience Methods 14 (1985) 149-167
62. Rodgers R.J., and Cole J.C. Anxiolytic-like effect of (S)-WAY 100135, a 5-HT1A receptor antagonist, in the murine elevated plus-maze test. European Journal of Pharmacology 261 (1994) 321-325
63. Rodgers R.J., and Johnson N.J. Factor analysis of spatiotemporal and ethological measures in the murine elevated plus-maze test of anxiety. Pharmacology Biochemistry and Behavior 52 (1995) 297-303
64. Rodgers R.J., Lee C., and Shepherd J.K. Effects of diazepam on behavioural and antinociceptive responses to the elevated plus-maze in male mice depend upon treatment regimen and prior maze experience. Psychopharmacology (Berl) 106 (1992) 102-110
65. Rodgers R.J., Cutler M.G., and Jackson J.E. Behavioural effects in mice of subchronic chlordiazepoxide, maprotiline and fluvoxamine. II. The elevated plus-maze. Pharmacology Biochemistry and Behavior 57 (1997) 127-136
66. Rosen J.B., and Schulkin J. From normal fear to pathological anxiety. Psychological Review 105 (1998) 325-350
67. Salman M.D., New Jr. J.G., Scarlett J.M., Kris P.H., Ruch-Gallie R., and Suzanne Hetts S. Human and animal factors related to the relinquishment of dogs and cats in 12 selected animal shelters in the United States. Journal of Applied Animal Welfare Science J 3 (1998) 207-226
68. Schmidt M.V., Oitzl M.S., Levine S., and de Kloet E.R. The HPA system during the postnatal development of CD1 mice and the effects of maternal deprivation. Brain Research. Developmental Brain Research 139 (2002) 39-49 (Erratum in: Brain Research. Developmental Brain Research 160, 287)
69. Schwartz S. Separation anxiety syndrome in dogs and cats. Journal of the American Veterinary Medical Association 222 (2003) 1526-1532
70. Shelden M.H. Exploratory behaviour: the inadequacy of activity measures. Psychonomic Science 11 (1968) 38
71. Shepherd J.K., Grewal S.S., Fletcher A., Bill D.J., and Dourish C.T. Behavioral and pharmacological characterization of the elevated "zero-maze" as an animal model of anxiety. Psychopharmacology 116 (1994) 56-64
72. Sullivan G.M., Coplan J.D., Kent J.M., and Gorman J.K. The noradrenergic system in pathological anxiety: a focus on panic with relevance to generalized anxiety and phobias. Biological Psychiatry 46 (1999) 1205-1218
73. Treit D., and Fundytus M. Thigmotaxis as a test for anxiolytic activity in rats. Pharmacology Biochemistry and Behavior 31 (1988) 959-962
74. van der Staay F.J. Animal models of behavioral dysfunctions: classifications, and an evaluation strategy. Brain Research Reviews 52 (2006) 131-159
75. van der Staay F.J., Kerbusch S., and Raaijmakers W. Genetic correlations in validating emotionality. Behavior Genetics 20 (1990) 51-62
76. Veenema A.H., Meijer O.C., de Kloet E.R., and Koolhaas J.M. Genetic selection for coping style predicts stressor susceptibility. Journal of Neuroendocrinology 15 (2003) 256-267
77. Weiss J.M. Effects of coping responses on stress. Journal of Comparative and Physiological Psychology 65 (1968) 251-260
78. Weiss J.M. Stress-induced depression: critical neurochemical and electrophysiological changes. In: Madden J.I.V. (Ed). Neurobiology of Learning, Emotion and Affect (1991), Raven, New York 123-154