Impaired repair of cyclobutane pyrimidine dimers in human keratinocytes deficient in p53 and p63

Carcinogenesis

Volumn 29, Issue 1, 2008, Pages 70-75

  Ferguson Yates, Bridget E ^a,b   Li, Hongyan ^a,b   Dong, Tiffany K ^a,b   Hsiao, Jennifer L ^a,b   Oh, Dennis H ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLOBUTANE; DNA; MESSENGER RNA; NUCLEIC ACID BINDING PROTEIN; PROTEIN DDB2; PROTEIN E6; PROTEIN E7; PROTEIN P53; PROTEIN P63; PROTEIN P73; PYRIMIDINE DIMER; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; XERODERMA PIGMENTOSUM GROUP C PROTEIN;

ARTICLE; CONTROLLED STUDY; DNA DAMAGE; DNA REPAIR; EXCISION REPAIR; FAMILIAL CANCER; HUMAN; HUMAN CELL; KERATINOCYTE; NEWBORN; POSTTRANSCRIPTIONAL GENE SILENCING; PRIORITY JOURNAL; PROTEIN DEPLETION; PROTEIN EXPRESSION; PROTEIN FUNCTION; SEQUENCE HOMOLOGY; SKIN CANCER; ULTRAVIOLET RADIATION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; BASE SEQUENCE; CELLS, CULTURED; DIMERIZATION; HUMANS; KERATINOCYTES; MEMBRANE PROTEINS; PYRIMIDINE DIMERS; RNA, SMALL INTERFERING; TUMOR SUPPRESSOR PROTEIN P53;

EID: 38849173662     PISSN: 01433334     EISSN: 14602180     Source Type: Journal    
DOI: 10.1093/carcin/bgm244     Document Type: Article

References (52)

1. Adimoolam,S. et al. (2002) p53 and DNA damage-inducible expression of the xeroderma pigmentosum group C gene. Proc. Natl Acad, Sci. USA 99, 12985-12990.
2. Hwang,B.J. et al. (1999) Expression of the p48 xeroderma pigmentosum gene is p53-dependent and is involved in global genomic repair. Proc. Natl Acad. Sci. USA, 96, 424-428.
3. DDB2 and p53. Mol. Cell. Biol., 23, 7540-7553.
4. Ford,J.M. (2005) Regulation of DNA damage recognition and nucleotide excision repair: Another role for p53. Mutat. Res., 577, 195-202.
5. Olivier,M. et al. (2003) Li-Fraumeni and related syndromes: correlation between tumor type, family structure and TP53 genotype. Cancer Res., 63, 6643-6650.
6. D'Errico,M. et al. (2003) Apoptosis and efficient repair of DNA damage protect human keratinocytes against UVB. Cell Death Differ. 10, 754-756.
7. D'Errico,M. et al. (2005) Differential role of transcription-coupled repair in UVB-induced response of human fibroblasts and keratinocytes. Cancer Res., 65, 432-438.
8. Ferguson,B.E. et al. (2005) Proficient global nucleotide excision repair in human keratinocytes but not fibroblasts deficient in p53. Cancer Res., 65, 8723-8729.
9. Oh,D.H. et al. (2005) Differentiating human keratinocytes are deficient in p53 but retain global nucleotide excision repair following utraviolet radiation. DNA Repair, 4, 1149-1159.
10. Ford,J.M. et al. (1998) Human fibroblasts expressing the human papillomavirus E6 gene are deficient in global genomic nucleotide excision repair and sensitive to ultraviolet irradiation. Cancer Res. 58, 599-603.
11. El-Mahdy,M.A. et al. (2000) p53-degradation by HPV-16 E6 preferentially affects the removal of cyclobutane pyrimidine dimers from non-transcribed strand and sensitizes mammary epithelial cells to UV-radiation. Mutat. Res., 459, 135-145.
12. Therrien,J.-P. et al. (1999) Human cells compromised fot p53 function exhibit defective global and transcription-coupled nucleotide excision repair, whereas cells compromised for pRb function are defective only in global repdir. Proc. Natl Acad. Sci. USA, 96 15038-15043.
13. Yang,A. et al. (1998) p63, a p53 homolog at 3q27-29; encodes multiple products with transactivating, death-inducing, and dominant-negative activities. Mol. Cell, 2, 306-316.
14. Kaghad,M. et al. (1997) Monoallelically expressed gene related to p53 at 1p36, a region frequently deleted in neuroblastoma and other human cancers. Cell, 90, 809-819.
15. KosterM.I. et al. (2004) p63 is the molecular switch for initiation of an epithelial stratification program. Genes Dev., 18, 126-131.
16. Brunner,H.G. et al. (2002) The p6S gene in and other syndromes. J. Med. Genet., 39, 337-381.
17. Senoo,M. et al. (2007) p63 is essential for the proliferative potential of stem cells in stratified epithelia. Cell, 129, 523-536.
18. Dellavalle,R.P. et al. (2002) CUSP/p63 expression in basal cell carcinoma. Exp. Dermatol., 11, 203-208.
19. Fomenkov,A. et al. (2004) RACK1 and stratifin target ΔNp63α for a proteasome degradation in head and neck squamous cell carcinoma cells upon DNA damage. Cell Cycle, 3, e27-e37.
20. Rocco,J.W. et al. (2006) p63 mediates survival in squamous cell carcinoma by suppression of p73-dependent apoptosis. Cancer Cell, 9, 45-56.
21. Reis-Filho,J.S. et al. (2002) p63 expression in normal skin and usual cutaneous carcinomas. J. Cutan. Pathol., 29, 517-523.
22. Di Como,C.J. et al. (2002) p63 expression profiles in human normal and tumor tissues. Clin. Cancer Res., 8, 494-501.
23. Nylander,K. et al. (2002) Differential expression of p63 isoforms in normal tissues and neoplastic cells. J. Pathol., 198, 417-427.
24. Wrone,D.A. et al. (2004) The expression of p63 in actinic keratoses, seborrheic keratosis, and cutaneous squamous cell carcinomas. Dermatol. Surg., 30, 1299-1302.
25. Flores,E.R. et al. (2005) Tumor predisposition in mice mutant for p63 and p73: Evidence for broader tumor suppressor functions for the p53 family. Cancer Cell, 7, 363-373.
26. Keyes,W.M. et al. (2006) p63 heterzygous mutant mice are not prone to spontaneous or chemically induced tumors. Proc. Natl Acad. Sci. USA, 103, 8435-8440.
27. Mills,A.A. (2006) p63: Oncogene or tumor suppressor. Curr. Opin. Genet. Dev., 16, 39-44.
28. Liefer,K.M. et al. (2000) Down-regulation of p63 is required for epidermal UV-B-induced apoptosis. Cancer Res., 60, 4016-4020.
29. Marchbank,A. et al. (2003) The CUSP ΔNp63α isoform of human p63 is downregulated by solar-simulated ultraviolet radiation. J. Dermatol. Sci., 32, 71-74.
30. Westfall,M.D. et al. (2005) Ultraviolet radiation induces phosphorylation and ubiquitin-mediated degradation of ΔNp63α. Cell Cycle, 4, 710-716.
31. Lee,H. et al. (2006) A dominant negative form of p63 inhibits apoptosis in a p53-independent manner. Biochem. Biophys. Res. Commun. 344, 166-172.
32. Katoh,I. et al. (2000) p51A (TAp63γ), a p53 homolog, accumulates in response to DNA damage for cell regulation. Oncogene, 19, 3126-3130.
33. Okada,Y. et al. (2002) p53 gene family p51(p63) encoded, secondary trans-activator p51B(TAp63α) occurs without forming an immunoprecipitable complex with MDM2, but responds to genotoxic stress by accumulation. Exp. Cell Res., 276, 194-200.
34. Zangen,R. et al. (2005) ΔNp63α levels correlate with clinical tumor response to cisplatin. Cell Cycle, 4, 1313-1315.
35. Flores,E.R. et al. (2002) p63 and p73 are required for p53-dependent apoptosis in response to DNA damage. Nature, 416 560-564.
36. Harmes,D.C. et al. (2003) Positive and negative regulation of ΔN-p63 promoter activity by p53 and ΔN-p63-α contributes to differential regulation of p53 target genes. Oncogene, 22, 7607-7616.
37. 3 of the major epidermis integrin anchoring the stem cells to the niche. J Biol. Chem., 279, 50069-50077.
38. Sugasawa,K. et al. (2005) UV-induced ubiquitylation of XPC protein mediated by UV-DDB-ubiquitin ligase complex. Cell, 121, 387-400.
39. Tang,J.Y. et al. (2000) Xeroderma pigmentosum p48 gene enhances global genomic repair and suppresses UV-induced mutagenesis. Mol. Cell, 5, 737-744.
40. Barbieri,C.E. et al. (2003) ΔNp63α expression is regulated by the phosphoinositide 3-kinase pathway. J. Biol. Chem., 278, 51408-51414.
41. Roth,J. et al. (1999) Failure of viral oncoproteins to target the p53-homologue p51A. J. Gen. Virol., 86, 3251-3255.
42. DeYoung,M.P. et al. (2006) Tumor-specific p73 up-regulation mediates p63 dependence in squamous cell carcinoma. Cancer Res., 66, 9362-9368.
43. Rapic-Otrin,V. et al. (2002) Sequential binding of UV DNA damage binding factor and degradation of the p48 subunit as early events after UV irradiation. Nucleic Acids Res., 30, 2588-2598.
44. McKeon,F. (2004) p63 and the epithelial stem cell: More than status quo? Genes Dev., 18, 465-469.
45. Yang,A. et al. (2002) On the shoulders of giants: P63, p73 and the rise of p53. Trends Genet., 18, 90-95.
46. Perez-Losada,J. et al. (2005) p63 and p73 do not contribute to p53-mediated lymphoma suppressor activity in vivo. Oncogene, 24, 5521-5524.
47. Brunner,H.G. et al. (2002) p63 gene mutations and human developmental syndromes. Am. J. Hum. Genet., 112, 284-290.
48. Tan,T. et al. (2002) p53 binds and activates the xeroderma pigmentosum DDB2 gene in humans but not mice. Mol. Cell Biol. 22, 3247-3254.
49. Araujo,S.J. et al. (2001) Strong functional interactions of TFIIH with XPC and XPG in human DNA nucleotide excision repair, without a preassembled repairosome. Mol. Cell. Biol., 21, 2281-2291.
50. Wittschieben,B.O. et al. (2003) DDB complexities. DNA Repair 2, 1065-1069.
51. Wang,Q.-E. et al. (2005) DNA repair factor XPC is modified by SUMO-1 and ubiquitin following UV irradiation. Nucleic Acids Res., 33, 4023-4034.
52. Chen,X. et al. (2006) A kinase-independent function of c-Abl in promoting proteolytic destruction of damaged DNA binding proteins. Mol. Cell, 22, 489-499.