Lanthanum carbonate effectively controls serum phosphate without affecting serum calcium levels in patients undergoing hemodialysis

Therapeutic Apheresis and Dialysis

Volumn 12, Issue 1, 2008, Pages 55-61

  Shigematsu, Takashi ^a   Sakai, Takehiko ^b   Iwasaki, Masashi ^b   Nagakura, Kazutake ^b   Murakami, Koichi ^b   Kono, Takashi ^c   Ando, Ken ^d   Kimura, Yasuo ^e   Sato, Junichi ^e   Tsuruta, Yoshinari ^f   Obayashi, Takaaki ^f   Kanashiro, Kana ^f   Seno, Hachiro ^g   Mori, Yasumitsu ^g   Murai, Hiroshi ^g   Nakao, Naoyuki ^g   Taki, Masafumi ^h   Arimoto, Katsuhiko ^h   Matsubara, Tatsuya ^h   Moriishi, Misaki ⁱ   Kawanishi, Hideki ⁱ   Watanabe, Hiroshi ⁱ   Minakuchi, Jun ^j   Kato, Takuma ^j   Hayashi, Ikuro ^j   Kaibara, Akihito ^j   Kawahara, Kazuhiko ^j   Nishida, Hayato ^j   Suzuki, Hiroko ^j   Takeda, Isao ^k   Kuwahara, Kazunori ^k   Sugita, Osamu ^k   Miyake, Susumu ^l   Noguchi, Tomonaga ^l   Yuasa, Kenji ^m   Ota, Kazumichi ^m   Terao, Naotami ^m   Sen, Yasukazu ^m   Iwasa, Yoshie ^m   Ishida, Mari ⁿ   Ishida, Yuji ⁿ   Nakao, Shoko ⁿ   Kobayashi, Takeshi ⁿ   Yachiku, Setsuko ⁿ   Komura, Chikashi ⁿ   Yao, Naoyuki ⁿ   Tsujimoto, Yoshihiro ^o   Tabata, Tsutomu ^o   Tahara, Hideki ^o   more..

^a WAKAYAMA MEDICAL UNIVERSITY   (Japan)

^b Mihama Hospital

^c Mihama Narita Clinic

^d Mihama Shizu Clinic

^e New Kashiwa Clinic

^f Meiyo Clinic

^g Ama Kyoritsu Clinic

^h Shigei Medical Research Hospital

ⁱ Nakajima Tsutiya Clinic

^j Kawashima Hospital   (Japan)

^k Kochi General Rehabilitation Hospital   (Japan)

^l Shimazu Hospital

^m Kochi Takasu Hospital

ⁿ Kitasaito Hospital

^o Inoue Hospital

more..

Author keywords

Calcium phosphate product; Chronic kidney disease; Hyperphosphatemia; Lanthanum carbonate; Secondary hyperparathyroidism

Indexed keywords

BAY 77 1931; LANTHANUM CARBONATE; PHOSPHATE; PLACEBO; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG BLOOD LEVEL; DRUG EFFICACY; DRUG SAFETY; FEMALE; HEMODIALYSIS PATIENT; HUMAN; INCIDENCE; KIDNEY FAILURE; MALE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL;

ADULT; AGED; ASIAN CONTINENTAL ANCESTRY GROUP; CALCIUM; DOSE-RESPONSE RELATIONSHIP, DRUG; DOUBLE-BLIND METHOD; FEMALE; HUMANS; HYPERPHOSPHATEMIA; JAPAN; KIDNEY FAILURE, CHRONIC; LANTHANUM; MALE; MIDDLE AGED; PARATHYROID HORMONE; PHOSPHATES; RENAL DIALYSIS;

EID: 38849167379     PISSN: 17449979     EISSN: 17449987     Source Type: Journal    
DOI: 10.1111/j.1744-9987.2007.00541.x     Document Type: Article

References (10)

1. Block GA, Port FK. Re-evaluation of risks associated with hyperphosphatemia and hyperparathyroidism in dialysis patients: recommendation for a change in management. Am J Kidney Dis 2000 35 : 1226 37.
2. Block GA, Klassen PS, Lazarus JM, Ofsthun N, Lowrie EG, Chertow GM. Mineral metabolism, mortality, and morbidity in maintenance hemodialysis. J Am Soc Nephrol 2004 15 : 2208 18.
3. Young EW, Albert JM, Satayathum S et al. Predictors and consequences of altered mineral metabolism: The Dialysis Outcomes and Practice Patterns Study. Kidney Int 2005 67 : 1179 87.
4. National Kidney Foundation. K/DOQI clinical practice guideline for bone metabolism and disease in chronic kidney disease. Am J Kidney Dis 2003 42 : s62 s84.
5. Chetow GM, Raggi P, Chasan-Taber S, Bommer J, Holzer H, Burke SK. Determinants of progressive vascular calcification in haemodialysis patients. Nephrol Dial Transplant 2004 19 : 1489 96.
6. Ogata H, Koiwa F, Shishido K, Kinugasa E. Combination therapy with sevelamer hydrochloride and calcium carbonate in Japanese patients with long-term hemodialysis: alternative approach for optimal mineral management. Ther Apher Dial 2005 9 : 11 15.
7. Albaaj F, Hutchison AJ. Lanthanum carbonate for the treatment of hyperphosphatemia in renal failure and dialysis patients. Expert Opin Pharmacother 2005 6 : 319 28.
8. Iwasaki Y, Takami H, Tani M et al. Efficacy of combined sevelamer and calcium carbonate therapy for hyperphosphatemia in Japanese hemodialysis patients. Ther Apher Dial 2005 9 : 347 51.
9. Koiwa F, Onoda N, Kato H et al. Prospective randomized multicenter trial of sevelamer hydrochloride and calcium carbonate for the treatment of hyperphosphatemia in hemodialysis patients in Japan. Ther Apher Dial 2005 9 : 340 6.
10. Joy MS, Finn WF, LAM-302 Study Group. Randomized, double-blind, placebo-controlled, dose-titration, Phase III study assessing the efficacy and tolerability of lanthanum carbonate. A new phosphate binder for the treatment of hyperphosphatemia. Am J Kidney Dis 2003 42 : 96 107.