S-Euglobals: Biomimetic synthesis, antileishmanial, antimalarial, and antimicrobial activities

Bioorganic and Medicinal Chemistry

Volumn 16, Issue 3, 2008, Pages 1328-1336

  Bharate, Sandip B ^a   Khan, Shabana I ^b   Tekwani, Babu L ^b   Jacob, Melissa ^b   Khan, Ikhlas A ^b   Singh, Inder Pal ^a  

^a NATIONAL INSTITUTE OF PHARMACEUTICAL EDUCATION AND RESEARCH NIPER   (India)

^b UNIVERSITY OF MISSISSIPPI   (United States)

Author keywords

Antileishmanial; Antimalarial; Antimicrobial; Euglobals; Phloroglucinol; Robustadial A and B; S Euglobals

Indexed keywords

3,4 DIHYDRO 5,7 DIHYDROXY 3',3' DIMETHYL 6,8 DI (3 METHYLBUTANOYL) SPIRO 2H 1 BENZOPYRAN 2,2' BICYCLO[2.2.1]HEPTANE; 5,7 DI (3 METHYLBUTANOYL) 2,3,4,4A,9,9A HEXAHYDRO 6,8 DIHYDROXY 3,3,4A TRIMETHYL 2,4 METHANO 1H XANTHENE; 5,7 DIHYDROXY 1,1,2A TRIMETHYL 4,6 DI (3 METHYLBUTANOYL) 1,1A,2,2A,8,8A,9,9A OCTAHYDRO 3 OXACYCLOPROP[A]ANTHRACENE; 5,7 DIHYDROXY 1,1,9A TRIMETHYL 1,1A,2,3,3A,4,9A,9B OCTAHYDRO 9 OXACYCLOPROP[A]ANTHRACENE 6,8 DICARBALDEHYDE; 5,7 DIHYDROXY 1,1,9A TRIMETHYL 6 (3 METHYLBUTANOYL) 1,1A,2,3,3A,4,9A,9B OCTAHYDRO 9 OXACYCLOPROP[A]ANTHRACENE 8 CARBALDEHYDE; 5,7 DIHYDROXY 1,1,9A TRIMETHYL 6,8 DI (3 METHYLBUTANOYL) 1,1A,2,3,3A,4,9A,9B OCTAHYDRO 9 OXACYCLOPROP[A]ANTHRACENE; 5,7 DIHYDROXY 1,1,9A TRIMETHYL 8 (3 METHYLBUTANOYL) 1,1A,2,3,3A,4,9A,9B OCTAHYDRO 9 OXACYCLOPROP[A]ANTHRACENE 6 CARBALDEHYDE; 6,8 DI (3 METHYLBUTANOYL) 3,4 DIHYDRO 5,7 DIHYDROXY 6',6' DIMETHYL SPIRO 2H 1 BENZOPYRAN 2,2' BICYCLO[3.1.1]HEPTANE; 6,8 DIHYDROXY 3,3 DIMETHYL 4A HYDROXYETHYL 2,3,4,4A,9,9A HEXAHYDRO 2,4 METHANO 1H XANTHENE 5,7 DICARBOXALDEHYDE; 6,8 DIHYDROXY 3,3 DIMETHYL 4A HYDROXYETHYL 5 (3 METHYLBUTANOYL) 2,3,4,4A,9,9A HEXAHYDRO 2,4 METHANO 1H XANTHENE 7 CARBOXALDEHYDE; 6,8 DIHYDROXY 3,3 DIMETHYL 4A HYDROXYETHYL 5,7 DI (3 METHYLBUTANOYL) 2,3,4,4A,9,9A HEXAHYDRO 2,4 METHANO 1H XANTHENE; 6,8 DIHYDROXY 3,3 DIMETHYL 4A HYDROXYETHYL 7 (3 METHYLBUTANOYL) 2,3,4,4A,9,9A HEXAHYDRO 2,4 METHANO 1H XANTHENE 5 CARBOXALDEHYDE; 6,8 DIHYDROXY 3,3 DIMETHYL 4A HYDROXYMETHYL 2,3,4,4A,9,9A HEXAHYDRO 2,4 METHANO 1H XANTHENE 5,7 DICARBOXALDEHYDE; 6,8 DIHYDROXY 3,3 DIMETHYL 4A HYDROXYMETHYL 5 (3 METHYLBUTANOYL) 2,3,4,4A,9,9A HEXAHYDRO 2,4 METHANO 1H XANTHENE 7 CARBOXALDEHYDE; 6,8 DIHYDROXY 3,3 DIMETHYL 4A HYDROXYMETHYL 5,7 DI (3 METHYLBUTANOYL) 2,3,4,4A,9,9A HEXAHYDRO 2,4 METHANO 1H XANTHENE; 6,8 DIHYDROXY 3,3 DIMETHYL 4A HYDROXYMETHYL 7 (3 METHYLBUTANOYL) 2,3,4,4A,9,9A HEXAHYDRO 2,4 METHANO 1H XANTHENE 5 CARBOXALDEHYDE; AMPHOTERICIN B; ANTIINFECTIVE AGENT; ANTILEISHMANIAL AGENT; ANTIMALARIAL AGENT; ARTEMISININ; CHLOROQUINE; CIPROFLOXACIN; DOXORUBICIN; PENTAMIDINE; PHLOROGLUCINOL; ROBUSTADIAL A; ROBUSTADIAL B; TERPENE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIBACTERIAL ACTIVITY; ANTIMALARIAL ACTIVITY; ANTIMICROBIAL ACTIVITY; ARTICLE; ASPERGILLUS FUMIGATUS; BIOMIMETICS; CANCER CELL CULTURE; CANDIDA ALBICANS; CELL STRAIN KB; CHEMICAL REACTION; CONTROLLED STUDY; CRYPTOCOCCUS NEOFORMANS; CYCLOADDITION; DIELS ALDER REACTION; DRUG CYTOTOXICITY; DRUG POTENCY; DRUG SYNTHESIS; FEMALE; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; KNOEVENAGEL CONDENSATION; LEISHMANIA DONOVANI; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; MYCOBACTERIUM INTRACELLULARE; NONHUMAN; PLASMODIUM FALCIPARUM; PROMASTIGOTE; VERO CELL;

ANIMALS; ANTI-BACTERIAL AGENTS; ANTIPROTOZOAL AGENTS; BIOMIMETIC MATERIALS; LEISHMANIA DONOVANI; MAGNETIC RESONANCE SPECTROSCOPY; MOLECULAR STRUCTURE; MYCOBACTERIUM AVIUM COMPLEX; PHLOROGLUCINOL; PLASMODIUM FALCIPARUM; STAPHYLOCOCCUS AUREUS; STRUCTURE-ACTIVITY RELATIONSHIP; TERPENES;

ALNUS; LEISHMANIA DONOVANI; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; PLASMODIUM FALCIPARUM;

EID: 38849111959     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2007.10.055     Document Type: Article

References (15)

1. Singh I.P., and Bharate S.B. Nat. Prod. Rep. 23 (2006) 558
2. Singh I.P., and Etoh H. Nat. Prod. Sci. 3 (1997) 1
3. Ghisalberti E.L. Phytochemistry 41 (1996) 7
4. Bharate S.B., Bhutani K.K., Khan S.I., Tekwani B.L., Jacob M.R., Khan I.A., and Singh I.P. Bioorg. Med. Chem. 14 (2006) 1750
5. Bharate S.B., Khan S.I., Yunus N.A., Chauthe S.K., Jacob M.R., Tekwani B.L., Khan I.A., and Singh I.P. Bioorg. Med. Chem. 15 (2007) 87
6. Bharate S.B., and Singh I.P. Tetrahedron Lett. 47 (2006) 7021
7. Bharate S.B., Chauthe S.K., Bhutani K.K., and Singh I.P. Aust. J. Chem. 58 (2005) 551
8. Mikus J., and Steverding D. Parasitol. Int. 48 (2000) 265
9. Ma G., Khan S.I., Jacob M.R., Tekwani B.L., Li Z., Pasco D.S., Walker L.A., and Khan I.A. Antimicrob. Agents Chemother. 48 (2004) 4450
10. Mustafa J., Khan S.I., Ma G., Walker L.A., and Khan I.A. Lipids 39 (2004) 167
11. Makler M.T., and Hinrichs D. J. Am. J. Trop. Med. Hyg. 48 (1993) 205
12. NCCLS, In Reference Method for Broth Dilution, Antifungal Susceptibility Testing of Yeasts; Approved Standard M27-A, National Committee on Clinical Laboratory Standards, 1997; Vol. 17, p 9.
13. NCCLS, In Methods for Dilution Antimicrobial Susceptibility Tests for Bacteria that Grow Aerobically M7-A5, National Committee on Clinical Laboratory Standards, 2000; Vol. 20, p 2.
14. NCCLS, In Susceptibility testing of Mycobacteria, Nocardia, and other aerobic actinomycetes; tentative standard, 2nd ed.; M24-T2, National Committee on Clinical Laboratory Standards, 2000; Vol. 20, p 26.
15. Franzblau S.G., Witzig R.S., McLaughlin J.C., Torres P., Madico G., Hernandez A., Degnan M.T., Cook M.B., Quenzer V.K., Ferguson R.M., and Gilman R.H. J. Clin. Microbiol. 36 (1998) 362