Treatment of subclinical hypothyroidism reduces atherogenic lipid levels in a placebo-controlled double-blind clinical trial

Hormone and Metabolic Research

Volumn 40, Issue 1, 2008, Pages 50-55

  Teixeira, P F S ^a,b   Reuters, V S ^a   Ferreira, M M ^a   Almeida, C P ^a   Reis, F A A ^a   Melo, B A ^a   Buescu, A ^a   Costa, A J L ^a   Vaisman, M ^a  

^a FEDERAL UNIVERSITY OF RIO DE JANEIRO   (Brazil)

^b NONE   (Brazil)

Author keywords

Cholesterol; Clinical trial; Levothyroxine; Lipid; Subclinical hypothyroidism; Thyroid

Indexed keywords

CHOLESTEROL; LEVOTHYROXINE; LOW DENSITY LIPOPROTEIN CHOLESTEROL; PLACEBO; THYROTROPIN; THYROXINE;

ADULT; AGE DISTRIBUTION; ARTICLE; ATHEROGENESIS; BODY MASS; CHOLESTEROL BLOOD LEVEL; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; FEMALE; HASHITOXICOSIS; HUMAN; HYPOTHYROIDISM; LIPID BLOOD LEVEL; MAJOR CLINICAL STUDY; MALE; MENOPAUSE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SITTING; TACHYCARDIA; THYROID DISEASE; THYROTROPIN BLOOD LEVEL; THYROXINE BLOOD LEVEL;

ATHEROSCLEROSIS; DOUBLE-BLIND METHOD; FEMALE; HUMANS; HYPOTHYROIDISM; LIPID METABOLISM; MALE; MENOPAUSE; PLACEBOS; THYROXINE;

EID: 38849095297     PISSN: 00185043     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2007-993216     Document Type: Article

References (27)

1. Surks MI, Ortiz E, Daniels GH, Sawin CT, Col NF, Cobin RH, Franklyn JA, Hershmam JM, Burman KD, Denke MA, Gorman C, Cooper RS, Weissman NJ. Subclinical Thyroid Disease. Scientific review and guidelines for diagnosis and management. JAMA 2004; 291: 228-238
2. Hollowell JG, Staehling NW, Flanders WD, Hannon WH, Gunter EW, Spencer CA, Braverman LE. Serum TSH, T4 and thyroid antibodies in the United States population (1988-1994): National Health and Nutrition Examination Survey (NHANES III). J Clin Endocrinol Metab 2002; 87: 489-499
3. Tunbridge WM, Evered DC, Hall R, Appleton D, Brewis M, Clark F, Evans JG, Young E, Bird T, Smith PA. Lipid profiles and cardiovascular disease in the Whickham area with particular reference to thyroid failure. Clinical Endocrinol (Oxf) 1977; 7: 495-508
4. Canaris GJ, Manowitz NR, Mayor G, Ridgway EC. The Colorado thyroid disease prevalence study. Arch Intern Med 2000; 160: 526-534
5. Cabral MD, Costa A J L, Santos MC F, Vaisman M. Lipid profile in subclinical hypothyroidism. Endocrinologist 2004; 14: 121-125
6. Hak AE, Pols HA, Visser TJ, Drexhage HA, Hofman A, Witteman JC. Subclinical hypothyroidism is an independent risk factor for atherosclerosis and myocardial infarction in elderly women: the Rotterdam Study. Ann Intern Med 2003; 132: 270-278
7. Franklyn JA, Sheppard MC, Maisonneuve P. Thyroid function and mortality in patients treated for hyperthyroidism. JAMA 2005; 294: 71-80
8. Chu JW, Capro LM. Clinical perspective. The treatment of subclinical hypothyroidism is seldom necessary. J Clin Endocrinol Metab 2001; 86: 4591-4599
9. Michalopoulou G, Alevizaki M, Piperingos G, Mitsibounas D, Mantzos E, Adamapoulos P, Koutras DA. High serum cholesterol levels in persons with 'high-normal' TSH levels: should one extend the definition of subclinical hypothyroidism? Eur J Endocrinol 1998; 138: 141-145
10. Duntas LH. Thyroid disease and lipids. Thyroid 2002; 2: 287-293
11. Danese MD, Ladenson P W, Meinert CL, Powe N R. Clinical review 115: Effect of thyroxine therapy on serum lipoproteins in patients with mild thyroid failure: A quantitative review of the literature. J Clin Endocrinol Metab 2000; 85: 2993-3001
12. Cooper DS, Halpern R, Wood LC, Levin AA, Ridgway EC. l-thyroxine therapy in subclinical hypothyroidism. Ann Intern Med 1984; 101: 18-24
13. Nystrom E, Caidahl K, Fager G, Kikkelso C, Lundberg PA, Lindstedt G. A double-bind cross-over 12-month study of l-thyroxine treatment of women with subclinical hypothyroidism. Clin Endocrinol (Oxf) 1988; 29: 63-76
14. Meier C, Staub JJ, Roth CB, Guglielmetti M, Kunz M, Miserez AR, Drewe J, Huber P, Herzog R, Muller B. TSH-controlled l-thyroxine therapy reduces cholesterol levels and clinical symptoms in subclinical hypothyroidism: A double-bind placebo-controlled trial (Basel Thyroid Study). J Clin Endocrinol Metab 2001; 86: 4860-4866
15. Caraccio N, Ferrannini E, Monzani F. Lipoprotein profile in subclinical hypothyroidism: Response to levothyroxine replacement, a randomized placebo-controlled study. J Clin Endocrinol Metab 2002; 87: 1533-1538
16. Monzani F, Caraccio N, Kozakowa M, Dardano A, Vittone F, Virdis A, Taddei S, Palombo C, Fenanini E. Effect of levothyroxine replacement on lipid profile and intima-media thickness in subclinical hypothyroidism: a double-blind, placebo- controlled study. J Clin Endocrinol Metab 2004; 89: 2099-2106
17. Zulewski H, Muller B, Exer P, Miserez AR, Staub JJ. Estimation of tissue hypothyroidism by a new clinical score: evaluation of patients with various grades of hypothyroidism and controls. J Clin Endocrinol Metab 1997; 82: 771-776
18. National Cholesterol Education Program (U.S.). Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults. Third report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III): final report. Bethesda: National Cholesterol Education Program, National Heart, Lung, and Blood Institutes, National Institutes of Health, 2002;336
19. Ozata M, Yildirimkaya M, Yilmaz K, Kutluay T, Corakci A, Beyhan Z, Gundogan MA. The effects of thyroid status on serum apolipoprotein A-l containing lipoprotein particles. Horm Metab Res 1998; 30: 217-221
20. Milionis HJ, Efstahiadou Z, Tselepis AD, Bairakitari ET, Tsironis LD, Tsatsoulis A, Lisaf MS. Lipoprotein (a) levels and apoprotein (a) in patients with subclinical hypothyroidism: Effect of treatment with levothyroxine. Thyroid 2005; 15: 455-460
21. Ganotakis ES, Mandalaki K, Tampakaki M, Malliaraki N, Mandalakis E, Vrentzos G, Melissas J, Castanas E. Subclinical hypothyroidism and lipid abnormalities in older women attending a vascular disease prevention clinic: Effect of thyroid replacement therapy. Angiology 2003; 54: 569-574
22. Efstathiadou Z, Bitsis S, Milionis HJ, Kukuvits A, Bairaktari ET, Elisaf MS, Tsatsoulis A. Lipid profile in subclinical hypothyroidism: is l-thyroxine substitution beneficial? Eur J Endocrinol 2001; 145: 705-710
23. Tsimihodimos V, Bairaktak E, Tzallas C, Miltiadus G, Liberopoulos E, Elisaf M. The incidence of thyroid function abnormalities in patients attending an outpatient lipid clinic. Thyroid 1999; 9: 365-368
24. Kong WM, Sheikh MH, Lumb PJ, Naoumova RP, Freedman DB, Crook M, Dore CJ, Finer N. A 6-month randomized trial of thyroxine treatment in women with mild subclinical hypothyroidism. Am J Med 2002; 112: 348-354
25. Rosenthal MJ, Hunt WC, Garry PJ, Goodwin JS. Thyroid failure in the elderly: microsomal antibodies as discriminant for therapy. JAMA 2002; 258: 209-213
26. Vanderpump MP, Tunbridge WM. Epidemiology and prevention of clinical and subclinical hypothyroidism. Thyroid 2002; 12: 839-847
27. Kabadi UM. Subclinical hypothyroidism. Natural course of the syndrome during a prolonged follow-up study. Arch Intern Med 1993; 153: 957-961