Is C-peptide replacement the missing link for successful treatment of neurological complications in type 1 diabetes?

Current Drug Targets

Volumn 9, Issue 1, 2008, Pages 37-46

  Sima, Anders A F ^a   Kamiya, Hideki ^a,b  

^a WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b NAGOYA UNIVERSITY   (Japan)

Author keywords

C peptide; Neuropathy; Primary encephalopathy; Type 1 diabetes

Indexed keywords

ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); C PEPTIDE; CELL ADHESION MOLECULE; CYTOSKELETON PROTEIN; INSULIN; MESSENGER RNA; NEUROTROPHIC FACTOR; NITRIC OXIDE; TRANSCRIPTION FACTOR;

BRAIN DISEASE; CLINICAL TRIAL; COGNITIVE DEFECT; DIABETIC NEUROPATHY; DOSE RESPONSE; DRUG MECHANISM; ENZYME ACTIVITY; HORMONE ACTION; HUMAN; INSULIN DEPENDENT DIABETES MELLITUS; MYELINATED NERVE; NERVE CELL NECROSIS; NERVE CELL PLASTICITY; NERVE FIBER DEGENERATION; NEUROPATHOLOGY; NONHUMAN; NONMYELINATED NERVE; PATHOPHYSIOLOGY; POLYNEUROPATHY; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; REVIEW; SIGNAL TRANSDUCTION;

ANIMALS; BRAIN DISEASES, METABOLIC; C-PEPTIDE; COGNITION DISORDERS; DIABETES COMPLICATIONS; DIABETES MELLITUS, TYPE 1; DIABETIC NEUROPATHIES; GENE EXPRESSION REGULATION; HUMANS; INSULIN; SIGNAL TRANSDUCTION;

EID: 38849089253     PISSN: 13894501     EISSN: None     Source Type: Journal    
DOI: 10.2174/138945008783431745     Document Type: Review

References (160)

1. Sima, A.A.F. (2004) Ann. Neurol., 56, 459-461.
2. Kramer, L.; Fasching, P.; Madl, C.; Schneider, B.; Damjanic, P.; Waldhausl, W.; Irsigler, K.; Grimm, G. (1998) Diabetes, 47, 1909-1914.
3. Ott, A.; Stalk, R.P.; van Harskamp, F.; Pols, H.A.; Hofman, A.; Breteler, M.M. (1999) Neurology, 58, 1937-1941.
4. Sima, A.A.F.; Nathaniel, V.; Bril, V.; McEwen, T.A.J.; Greene, D.A. (1988) J. Clin. Invest., 81, 349-364.
5. Sima, A.A.F.; Bril, V, Greene, D.A. (1989) Pediatr. Adoles. Endocrin., 18, 56-62.
6. Sima, A.A.F. (2006) Ann. N. Y. Acad. Sci., 1084, 235-249.
7. Sima, A.A.F.; Kamiya, H.; Li, Z.-G. (2004) Eur. J. Pharmacol., 490, 187-197.
8. The Diabetes Control and Complications Trial Research Group (1993) N. Engl. J. Med., 329, 977-986.
9. U.K. Prospective Diabetes Study (UKPDS) Group (1998) Lancet, 352, 837-853.
10. Sima, A.A.F.; Kamiya, H. (2004) Sci. Med., 10, 308-319.
11. Sima, A.A.F. (2006) Curr. Opin. Invest. Drugs, 7, 324-337.
12. Brussee, V.; Cunningham, F.A.; Zochodne, D.W. (2004) Diabetes, 53, 1824-1830.
13. Toth, C.; Brussee, V.; Zochodne, D.W. (2006) Diabetologia, 49, 1081-1088.
14. Fernyhough, P.; Mill, J.F.; Roberts, J.L.; Ishii, D.N. (1989) Brain Res. Mol. Brain Res., 6, 109-120.
15. Sima, A.A.F.; Zhang, W.; Li, Z.-G.; Murakawa, Y.; Pierson, C.R. (2004) Diabetes, 53, 1556-1563.
16. Sima, A.A.F.; Li, Z.-G.(2005) Diabetes, 54, 1497-1505.
17. Kamiya, H.; Zhang, W.; Sima, A.A.F. (2005) Diabetes, 54, 3288-3295.
18. Li, Z.-G.; Zhang, W.; Sima, A.A.F. (2003) Diab. Metab. Res. Rev., 19, 375-385.
19. Dyck, P.J.; Daview, J.L.; Wilson, D.M.; Service, F.J.; Melton, L.J. 3rd, O;Brien, P.C. (1999) Diabetes Care, 22, 1479-1486.
20. Sima, A.A.F.; Zhang, W.; Xu, G.; Sugimoto, K.; Guberski, D.L.; Yorek, M.A. (2000) Diabetologia, 43, 786-793.
21. Pierson, C.R.; Zhang, W.; Murakawa, Y.; Sima, A.A.F. (2003) J. Neuropath. Exp. Neurol., 62, 260-271.
22. Kamiya, H.; Murakawa, Y.; Zhang, W.; Sima, A.A.F. (2005) Diab. Metab. Res. Rev., 21, 448-458.
23. Schmidt, R.E.; Dorsey, D.A.; Beaudet, L.N.; Parvin, C.A.; Zhang, W.; Sima, A.A.F.(2004) J. Neuropath. Exp. Neurol., 63, 450-460.
24. Li, Z.; Zhang, W.; Grunberger, G.; Sima, A.A.F. (2002) Brain Res., 946, 212-231.
25. Li, Z.-G.; Zhang, W.; Sima, A.A.F. (2005) Brain Res., 1037, 12-24.
26. Li, Z.; Sima, A.A.F. (2007) Diabetes, 56, 1817-1824.
27. Grunberger, G.; Qiang, X.; Li, Z.-G.; Mathews, S.T.; Sbriessa, D.; Shisheva, A.; Sima, A.A.F. (2001) Diabetologia, 44, 1247-1257.
28. Sima, A.A.F. (2003) Expert Opin. Investig. Drugs, 12, 1471-1488.
29. Jensen, M.E.; Messina, E.J. (1999) Am. J. Physiol., 276, H1223-H1228.
30. Steiner, D.; Cunningham, D.; Spigelman, L.; Aten, B. (1967) Science, 157, 697-700.
31. Steiner, D.F.; Oyer, P.E. (1967) Proc. Natl. Acad. Sci. USA, 57, 473-481.
32. Rigler, R.; Pramanik, A.; Jonasson, P.; Kratz, G.; Jansson, O.T.; Nygren, P.-A.; Stahl, S.; Ekberg, K.; Johansson, B.-L.; Uhlén, S.; Uhlén, M.; Jörnvall, H.; Wahren, J. (1999) Proc. Natl. Acad. Sci. USA, 96, 13318-13323.
33. Ido, Y.; Vindigni, A.; Chang, K.; Stramm, L.; Chance, R.; Heath, W.F.; DiMarchi, R.D.; Di Cera, E.; Williamson, J.R. (1997) Science, 25, 563-566.
34. Al-Rasheed, N.; Willars, G.; Brunskill, N.J. (2006) J. Am. Soc. Nephrol., 17, 986-995.
35. Shafqat J.; Juntti-Berggren, L.; Zhong, Z.; Ekberg, K, Köhler, M, Berggren, P.-O.; Johansson, J.; Wahren, J.; Jörnvall, H. (2002) Cell Mol. Life Sci., 59, 1185-1189.
36. Wallerath, T.; Kunt, T.; Forst, T.; Closs, E.I.; Lehmann, R.; Flohr, T.; Gabriel, M.; Schafer, D.; Gopfert, A.; Pfützner, A.; Beyer, J.; Forstermann, U. (2003) Nitric Oxide, 9, 95-102.
37. Johansson, B.-L.; Kernell, A.; Sjöberg, S.; Wahren, J. (1993) J. Clin. Endocrinol. Metab., 77, 976-981.
38. Grunberger, G.; Sima, A.A.F. (2004) Exp. Diab. Res., 5, 25-36.
39. Kitamura, T.; Kimura, K.; Makondo, Furuya, D.T.; Suzuki, M.; Yoshida, T.; Saito, M. (2003) Diabetologia, 46, 1698-1705.
40. Al-Rasheed, N.; Meakin, F.; Royal, E.; Lewington, A.J.; Brown, J.; Willars, G.; Brunskill, N. (2004) Diabetologia, 47, 987-997.
41. Zhong, Z.; Davidescu, A.; Ehrén, I.; Ekberg, K.; Jörnvall, H.; Wahren, I.; Chibalin, A.V. (2005) Diabetologia, 48, 187-197.
42. Shafqat, J.; Melles, E.; Sigmundsson, K.; Johansson, B.-L.; Ekberg, K.; Alvelins, G.; Henriksson, M.; Johansson, J.; Wahren, J.; Jörnvall, H. (2006) Cell Mol. Life Sci., 63, 1805-1811.
43. Scalia, R.; Coyle, K.; Levine, B.; Booth, G.; Lefer, A. (2000) FASEB J., 14, 2357-2364.
44. Joshua, I.; Zhang, Q.; Falcone, J.; Bratcher, A.; Rodriguez, W.; Tyagi, S. (2005) J. Cell Biochem., 96, 1149-1156.
45. Zhang, W.; Yorek, M.; Pierson, C.R.; Murakawa, Y.; Breidenbach, A.; Sima, A.A.F. (2001) Intl. J. Exp. Diab. Res., 2(3), 187-194.
46. Sima, A.A.F.; Zhang, W.-X.; Sugimoto, K.; Henry, D.; Li, Z.-G.; Wahren, J.; Grunberger, G. (2001) Diabetologia, 44, 889-897.
47. Sima, A.A.F.; Brismar T. (1985) Ann. Neurol., 18, 21-29.
48. Brismar, T.; Sima, A.A.F.; Greene, D.A. (1987) Ann. Neurol., 21, 504-507.
49. Greene, D.A.; Lattimer, S.A.; Sims, A.A.F. (1987) N. Engl. J. Med., 316, 599-606.
50. Greene, D.A.; Lattimer, S.A.; Sima, A.A.F. (1988) Diabetes, 37, 688-693.
51. Sugimoto, K.; Murakawa, Y.; Sima, A.A.F. (2000) Diab. Metab. Res. Rev., 16, 408-433.
52. Johansson, B.-L.; Linde, B.; Wahren, J. (1992) Diabetologia, 35, 1151-1158.
53. Cameron, N.E.; Cotter, M.A.; Archibald, V.; Dines, K.C.; Maxfield, E.K. (1994) Diabetologia, 37, 449-459.
54. Poston, L.; Taylor, P.D. (1995) Clin. Sci., 88, 245-255.
55. Morris, S.J.; Shore, A.C.; Tooke, J.E. (1995) Diabetologia, 38, 1337-1344.
56. Johnstone, M.T.; Creager, S.J.; Scales, K.M.; Cusco, J.A.; Lee, B.K.; Craeger, M.A. (1993) Circulation, 88, 2510-2516.
57. Li, H.; Xu, L.; Dunbar, J.C.; Dhabuwala, C.B.; Sima, A.A.F. (2004) J. Urol., 64, 622-627.
58. Sima, A.A.F. (2004) Neurol. Sci., 220, 133-136.
59. Stevens, M.J.; Zhang, W.; Li, F.; Sima, A.A.F. (2004) Am. J. Physiol., 287, E497-505.
60. Cotter, M.; Ekberg, K.; Wahren, J.; Cameron, N. (2001) Diabetes, 52, 1812-1817.
61. Xu, G.; Murakawa, Y.; Pierson, C.R.; Sima, A.A.F. (2002) J. Neuropath. Exp. Neurol., 61, 164-175.
62. Pierson, C.R.; Zhang, W.; Sima, A.A.F. (2003) J. Neuropath. Exp. Neurology, 62, 765-779.
63. Kamiya, H.; Zhang, W.; Sima, A.A.F. (2004) Ann. Neurol., 56, 827-835
64. Kamiya, H.; Zhang, W.; Ekberg, K.; Wahren, J.; Sima, A.A.F. (2006) Diabetes, 55, 3581-3587.
65. Li, Z.-G.; Qiang, X.; Sima, A.A.F.; Grunberger, G. (2001) Biochem. Biophys. Res. Com., 26, 615-619.
66. Sima, A.A.F.; Lattimer, S.A.; Yagihashi, S.; Greene, D.A. (1986) J. Clin. Invest., 77, 474-484.
67. Cherian, P.V.; Kamijo, M.; Angelides, K.J.; Sima, A.A.F. (1996) J. Diab. Compl., 10, 192-200.
68. Davis, J.Q.; Larabert, S.; Bennett V. (1996) J. Cell Biol., 135, 1355-1367.
69. Isom, L.L. (2002) Front. Biosci., 7, 12-23.
70. Pedraza, L.; Huang, J.K.; Colman, D.R. (2001) Neuron, 30, 335-344.
71. Davis, J.Q.; Lambert, S.; Bennett, V. (1996) J. Cell Biol., 135, 1355-1367.
72. Yamamoto, K.; Merry, A.; Sima, A.A.F. (1996) Dev. Brain Res., 96, 3645.
73. Kazarinova-Noyesk, K.; Malhotra, J.D.; McEwen, D.P.; Mattei, L.N.; Berglund, E.O.; Ranscht, B.; Levinson, S.R.; Schachner, M.; Shrager, P.; Isom, L.L, Xiao, Z.C. (2002) J. Neurosci., 21, 7517-7525.
74. Sima, A.A.F.; Nathaniel, V.; Prashar, A.; Bril, V.; Greene, D.A. (1991) Diabetes, 40, 1090-1099.
75. Sima, A.A.F.; Bouchier, M.; Christensen, H. (1983). Ann. Neurol., 13, 264-272.
76. Mordes, J.P.; Bortell, R.; Groen, H.; Guberski, D.; Rossini, A.A.; Greiner, D.L. (2001) In: Sima, A.A.F.; Shafrir, E. (eds.), Animal Models of Diabetes. Harwood Acad Publ.; Amsterdam, pp. 1-42.
77. Sima, A.A.F.; Merry, A.C.; Hall, D.E.; Grant; M.; Murray, F.T.; Guberski, D. (1997) Exp. Clin. Endocrin. Diab., 105, 63-64.
78. Sima, A.A.F. (2001) Expert Rev. Neurotherapeutics, 1, 225-238.
79. Greene, D.A.; Lattimer, S.A.; Sima, A.A.F. (1987) N. Engl. J. Med., 316, 599-606.
80. Stevens, M.J.; Feldman, E.L.; Thomas, T.P.; Greene, D.A. (1997) In: Veves A, Corn PMC (eds): Clinical management of diabetic neuropathy. Totowa, NJ, Humana Press, pp. 13-47.
81. Dvornik, D. (1987) In: Porte D (ed). Aldose reductase inhibition. New York, NY, Biomedical Information Corp. pp. 69-151.
82. Cameron, N.; Cotter, M.; Basso, M.; Hohman, T.C. (1097) Diabetologia, 40, 271-281.
83. Wahren, J.; Ekberg, K.; Jörnvall, H. (2007) Diabetologia, 50, 503-509.
84. Brownlee, M. (2001) Nature, 414, 813-820.
85. Pop-Busi, R.; Sima, A.A.F.; Stevens, M. (2006) Diab. Metab. Res. Rev.; 22, 257-273.
86. Sugimoto, K.; Sima, A.A.F. (1999) Diabetologia, 42, 773-788.
87. Brismar, T.; Sima, A.A.F. (1981) Acta Physiol. Scand., 113, 499-506.
88. Hirade, M.; Yasua, H.; Omatsu-Kanbe, M.; Kikkawa, R.; Kitasato, H. (1999) Neuroscience, 90, 933-939.
89. Lee, Y.H.; Ryu, T.G.; Park, S.J.; Yang, E.J.; Jeon, B.H.; Hur, G.M.; Kim, K.J. (2000) Neuroreport, 11, 1417-1420.
90. Burchiel, K.J.; Russel, L.C.; Lee, R.P.; Sima, A.A.F. (1985) Diabetes, 34, 1210-1213.
91. Zhang, W.; Murakawa, Y.; Wozniak, K.M.; Slusher, B.; Sima, A.A.F. (2002) J. Neurol. Sci., 194, 21-28.
92. Woolf, C.J.; Shortland, P.; Reynolds, H.; Ridings, J.; Doubell, T.; Coggeshall, R.E. (1995) J. Comp. Neurol., 360, 121-134.
93. Quarttrini, C.; Tesfaye, S. (2003) Diab. Metab. Res. Rev., 19, 52-58.
94. Tomlinson, D.R.; Fernyhough, P. (2000) In: Sima, A.A.F. (ed): Chronic complications in diabetes. Amsterdam, Harwood Acad Publ. pp 167-182.
95. Sugimoto, K.; Murakawa, Y.; Sima, A.A.F. (2002) JPNS, 7, 44-53.
96. Singleton, J.R.; Smith, A.G.; Bromberg, M.B. (2001) Diabetes Care, 24, 1448-1455.
97. Novella, S.P.; Inzuchi, S.E.; Goldstein, J.M. (2001) Muscle Nerve, 24, 1229-1231.
98. Murakawa, Y.; Zhang, W.; Pierson, C.R.; Brismar, T.; Östenson, C.-G.; Efendric, S.; Sima, A.A.F. (2002) Diab. Metab. Res. Rev., 18, 473-483.
99. Forst, T.; Dufayet de la Tour, D.; Kunt, T.; Pfützner, A.; Goitom, K.; Pohlmann, T.; Schneider, S.; Johansson, B.L.; Wahren, J.; Löbig, M.; Engelbach, M.; Beyer, J.; Vague, P. (2000) Clin. Sci. (Lond), 98, 283-290, 2000.
100. Kunt, T.; Schneider, S.; Pfützner, A.; Goitum, K.; Engelbach, M.; Schauf, B.; Beyer, J.; Forst, T. (1999) Diabetologia, 42, 465-471.
101. Ohtoma, Y.; Aperia, A.; Sahlgren, B.; Johansson, B.L.; Wahren, J. (1996) Diabetologia, 39, 199-205, 1996.
102. Zhang, W.; Kamiya, H.; Ekberg, K.; Wahren, J.; Sima, A.A.F. (2007) Diab. Metab. Res. Rev., 23, 63-70.
103. Cameron, N.E.; Cotter, M.A.; Archibald, V.; Dines, K.C.; Maxfield, E.K. (1994) Diabetologia, 37, 449-459.
104. Cameron, N.E.; Cotter, M.A. (2000) In Sima, A.A.F. (ed), Chronic complications in diabetes. Amsterdam, Harwood, pp 97-130.
105. Requena, J.K; Baynes, J.W. (2000) In Sima, A.A.F. (ed), Chronic complications in diabetes. Amsterdam, Harwood, pp 43-70.
106. Fernquist-Forbes, E.; Johansson, B.L.; Eriksson, M.J. (2001) Acta Physiol. Scand., 172, 159-165.
107. Fort, K.; Kunt, T.; Pohlmann, T.; Goitom, K.; Engelbach, M.; Bever, J.; Pfutzner, A. (1998) J. Clin Invest., 101, 2036-2041.
108. Yu, C.; Ronen, S.; Dobrowsky, R. (2007) Proc. 17th Neurodiab Meeting, Utrecht, Holland.
109. Hoffman, P.N.; Cleveland, D.W.; Griffin, J.W.; Landes, P.W.; Cowan, N.J.; Price, D.L. (1987) Proc. Natl. Acad. Sci. USA, 84, 3472-3476.
110. DeWaegh, S.M.; Lee, V.M.; Bradv, S.T. (1992) Cell, 68, 451-463.
111. Mobinddin, L.; Femyhough, P.; Tomlinson, D.R. (1995) Diabetes, 44, 25-30.
112. Scott, J.N.; Clark, A.W.; Zochodne, D.W. (1999) Brain, 122, 2109-2118.
113. Medori, R.; Jenich, H.; Antilio-Gambetti, L.; Gambetti, P. (1988) J. Neurosci., 8, 1814-1821.
114. Sayers, N.M.; Beswick, L.J.; Middlemas, A.; Calcutt, N.A.; Mizisin, A.P.; Tomlinson, D.R.; Fernyhough, P. (2003) Diabetes, 52, 2372-2380.
115. Terada, M.; Yasuda, H.; Kikkawa, R. (1998) J. Neurol. Sci. 155, 23-30.
116. Fernyhough, P.; Gallagher, A.; Averill, S.A.; Priestley, J.V.; Hounsom, L.; Patel, J.; Tomlinson, D.R. (1999) Diabetes, 48, 881-889.
117. Middlemas, A.; Delcroix, J.D.; Sayers, N.M.; Tomlinson, D.R.; Fernyhough, P. (2003) Brain, 126, 1671-1682.
118. Lee, M.K.; Xu, Z.; Wong, P.C.; Cleveland, D.W. (1993) J. Cell Biol., 122, 1337-1350.
119. Grant, P.; Pant, H.C. (2000) J. Neurocytol., 29, 843-872.
120. Sima, A.A.F. (2003). Cell Mol. Life Sci., 60, 2445-2464.
121. Sima, A.A.F. (1983) Metabolism, 32, Suppl. 1, 106-111.
122. Purves, T.; Middlemas, A.; Agthong, S.; Jude, F.B.; Boulton, A.J.; Fernyhough, P.; Tomlinson, D.R. (2001) FASEB J., 15, 2508-2514.
123. Brownlees, J.; Yates, A.; Bajaj, N.P.; Davis, D.; Anderton, B.H.; Leigh, P.N.; Shaw, C.F.; Miller, C.C. (2000) J. Cell Sci., 113, 401-407.
124. Li, B.S.; Veeranna, Gu, J.; Grant, P.; Pant, H.C. (1999) Eur. J. Biochem., 262, 211-217.
125. Mandelkow, E.; Mandelkow, E.M. (1995) Curr. Opin. Cell Biol., 7, 72-81.
126. Nunez, J.; Fischer, I. (1997) J. Mol. Neurosci., 8, 207-222.
127. Butner, K.A.; Kirschner, N.W. (1991) J. Cell Biol., 115, 717-730.
128. Zhou, F.Q.; Snider, W.D. (2005) Science, 303, 211-214.
129. Pierson, C.R.; Zhang, W.; Murakawa, Y.; Sima, A.A.F. (2002) J. Neuropath. Exp. Neurol., 61, 857-871.
130. Kamiya, H.; Zhang, W.; Sima, A.A.F. (2007) Proc. 17th Neurodiab. Meeting, Utrecht, Holland.
131. Sugimoto, K.; Murakawa, Y.; Zhang, W.-X; Xu, G.; Sima, A.A.F. (2000) Diab. Metab. Res. Rev., 16(5), 354-363.
132. Zochodne, D.W.; Verge, V.M.K.; Cheng, C.; Sun, H.; Johnston, J. (2001) Brain, 124, 2319-2334.
133. Zochodne, D.W.; Sun, H.; Cheng, C.; Eyer, J. (2004) Brain, 127, 2193-2200.
134. Thomas, P.K.; Beamich, N.G.; Small, J.R.; King, R.H.; Tesfaye, S.; Ward, J.D.; Tsigos, C.; Young, R.J.; Boulton, A.J. (1996) Acta Neuropathol., 92, 614-620.
135. Dyck, P.J.; Gianni, C. (1996) J. Neuropath. Exp. Neurol., 55, 1181-1193.
136. Sima, A.A.F. (1997) J. Neuropath. Exp. Neurol., 56, 458.
137. Malhotra, J.D.; Kazen-Gillespie, K.; Hortsch, M.; Isom, L.L. (2000) J. Biol. Chem., 275, 11383-11388.
138. Malhotra, J.D.; Koopman, M.C.; Kazen-Gillespie, K.A.; Fettman, M.; Hortsch, M.; Isom, L.L. (2002) J. Biol. Chem., 277, 26681-26688.
139. Einheber, S.; Zanazzi, G.; Ching, W.; Scherer, S.; Milner, T.A.; Peles, E.; Salzer, J.L. (1997) J. Cell Biol., 139, 1495-1506.
140. Peles, E.; Nativ, M.; Lustig, M.; Grumet, M.; Schilling, J.; Martinez, R.; Plowman, G.D.; Schlessinger, J. (1997) EMBO J., 16, 976-988.
141. Johansson, B.-L.; Borg, K., Fernquist-Forbes, E.; Odergren, T.; Remahl, S.; Wahren, J. (1996) Diabetologia, 39, 687-695,
142. Johansson, B.-L.; Borg, K.; Fernquist-Forhes, E.; Kernell, A.; Odergren, T.; Wahren; J. (2000) Diab. Med., 17, 181-189.
143. Ekberg, K.; Brismar, T.; Johansson, B.-L.; Jorisson B.; Lindström, P.; Wahren, J. (2003) Diabetes, 52, 536-541.
144. Ekberg, K.; Brismar, T.; Johansson, B.-L.; Lindström, P.; Juntti-Berggren, L.; Norrby, A.; Berne, C. Almquist, H.J.; Bolinder, J.: Wahren, J. (2007) Diabetes Care, 30, 71-76.
145. Arvanitakis, Z.; Wilson, R.S.; Bievas, J.L.; Evans, D.A.; Bennett, D.A. (2004) Arch. Neurol., 61, 661-666.
146. Schoenle, E.J.; Schoenle, D.; Mokiosari, L.; Largo, R.H. (2002) Diabetologia, 45, 108-114.
147. Ryan, C.M. (1988) Diabetes Care, 11, 86-93.
148. Sima, A.A.F.; Li, Z.-G. (2007) Diabetes, cognitive dysfunction and Alzheimer's disease. Diab. Metab. Res. Rev.; (in press).
149. Holmes, C.S.: Richman, L.C. (1985) J. Dev. Behav. Pediatr., 6, 323-326.
150. Lunetta, M.; Damanti, A.R.; Fabbri, G.; et al. (1994) J. Endocrinol. Invest., 17, 241-245.
151. Perros, P.; Deary, L.J.; Sellar, R.J.; Best, J.J.; Frier, B.M. (1997) Diabetes Care, 20, 1013-1018.
152. Dey, J.; Misra, A.; Desai, N.G.; Mahapatra, A.K.; Padma, M.V. (1997) Diabetes Care, 20, 32-35.
153. Ryan, C.M. (2006) Pediatric Diabetes, 7, 289-297.
154. Hoyer, S. (2004) Eur. J. Pharmacol., 490, 115-125.
155. Salkovic-Petrisic, M.; Tribl.; F.; Schmidt, M.; Hoyer, S.; Riederer, P. (2006) J. Neurochem., 96, 1005-1015.
156. Sima, A.A.F.; Li, Z.G. (2007) Rev. Diab. Stud., 4, 161-168.
157. Kamal, A.; Biessels, G.J.; Urban, I.J.; Gispen, W.H. (1999) Neuroscience, 90, 737-745.
158. Biessels, G.J.; Kamal, A.; Urban, I.J.; Spruijt, B.M.; Erkelens, D.W.; Gispen, W.H. (1998) Brain Res., 800, 125-135.
159. Li, Z.-G.; Zhang, W.; Sima, A.A.F. (2002) Int. J. Exp. Diab. Res., 3, 241-246.
160. Cheng, H.; Vetrivel, K.S.; Gong, P.; Meckler, X.; Parent, A.; Thinakaran, G. (2007) Nat. Clin. Pract. Neurol., 3, 374-382.