3,3-Diisopentenyl-N-methyl-2,4-quinoldione from Esenbeckia almawillia: The Antitumor Activity of this Alkaloid and its Derivatives

Natural Product Communications

Volumn 1, Issue 4, 2006, Pages 313-318

  Nunes, Fátima M ^a   Barros Filho, Bartholomeu A ^a   De Oliveira, Maria C F ^a   De Mattos, Marcos C ^a   Andrade Neto, Manoel ^a   Barbosa, Francisco G ^a   Mafezoli, Jair ^b   Montenegro, Raquel C ^a   Pessoa, Cláudia ^a   De Moraes, Manoel O ^a   Costa Lotufo, Letícia V ^a   Galetti, Fabio C S ^c   Silva, Celio L ^c   De Souza, Ana O ^d  

^a FEDERAL UNIVERSITY OF CEARÁ   (Brazil)

^b UNIVERSITY OF FORTALEZA   (Brazil)

^c UNIVERSITY OF SÃO PAULO   (Brazil)

^d INSTITUTO BUTANTAN   (Brazil)

Author keywords

3 3 diisopentenyl N methyl 2 4 quinoldione; Antitumor activity; Esenbeckia almawillia; Quinolone alkaloid; Rutaceae

Indexed keywords

EID: 38849084162     PISSN: 1934578X     EISSN: 15559475     Source Type: Journal    
DOI: 10.1177/1934578x0600100409     Document Type: Article

References (12)

1. Ratnayake S, Fang XP, Anderson JE, McLaughlin JL. (1992) Bioactive constituents from the twigs of Asimina parviflora. Journal of Natural Products, 55, 1462-1467.
2. Oliva A, Meepagala KM, Wedge DE, Harries D, Hale AL, Aliotta G., Duke SO. (2003) Natural fungicides from Ruta graveolens L. leaves, including a new quinolone alkaloid. Journal of Agricultural and Food Chemistry, 51, 890-896.
3. McCormick JL, McKee TC, Cardellina JH II, Boyd MR. (1996) HIV inhibitory natural products. 26 Quinoline alkaloids from Euodia roxburghiana. Journal of Natural Products, 59, 469-471.
4. Adams M, Wube AA, Bucar F, Bauer R, Kunert O, Haslinger E. (2005) Quinolone alkaloids from Evodia rutaecarpa: a potent new group of antimycobacterial compounds. International Journal of Antimocrobial Agents, 26, 262-264.
5. Coleman K. (2004) Recent advances in the treatment of Gram-positive infections. Drug Discovery Today: Therapeutic Strategies, 1, 455-459.
6. Barros-Filho BA, Nunes FM, de Oliveira MCF, Mafezoli J, Andrade-Neto M,. Silveira ER, Pirani J.R. (2004) Volatile constituents from Esenbeckia almawillia (Rutaceae). Biochemical Systematics and Ecology, 32, 817-821.
7. Johnstone RAW, Rose ME. (1979) A rapid, simple, and mild procedure for alkylation of phenols, alcohols, amides and acids. Tetrahedron, 35, 2169-2173.
8. Gigg R, Warren CD. (1969) Derivatives of 2,3,4,5,6-penta-O-benzyl-myo- inositol. Journal of the Chemical Society C, 2367-2371.
9. Willner I, Rabinovitz M. (1976) A new route to 1,2:7,8- dibenzocyclononatetraene via an electrocyclic reaction of 2,3:5,6- dibenzobicyclo[5.2.0]non-8-ene. Tetrahedron Letters, 17, 3335-3336.
10. Noland WE, Sellstedt JH. (1966) A new synthesis of o- nitrophenylacetaldehyde. Journal of Organic Chemistry, 31, 345-346.
11. Mosmann T. (1983) Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. Journal of Immunological Methods, 65, 55-63.
12. Collins LA, Franzblau SG. (1997) Microplate Alamar Blue assay versus BACTEC 460 system for high-throughput screening of compounds against Mycobacterium tuberculosis and Mycobacterium avium. Antimicrobial Agents and Chemotherapy, 41, 1004-1009.