A prospective, randomised, controlled clinical study on the assessment of tolerability and of clinical efficacy of Merional (hMG-IBSA) administered subcutaneously versus Merional administered intramuscularly in women undergoing multifollicular ovarian stimulation in an ART programme (IVF)

Reproductive Biology and Endocrinology

Volumn 5, Issue , 2007, Pages

  Alviggi, Carlo ^a   Revelli, Alberto ^b   Anserini, Paola ^c   Ranieri, Antonio ^a   Fedele, Luigi ^d   Strina, Ida ^a   Massobrio, Marco ^b   Ragni, Nicola ^c   De Placido, Giuseppe ^a  

^a UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^b UNIVERSITY OF TURIN   (Italy)

^c UNIVERSITY OF GENOA   (Italy)

^d SAN PAOLO HOSPITAL   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CHORIONIC GONADOTROPIN; GONASI; HUMAN MENOPAUSAL GONADOTROPIN; MERIONAL; PROGESTERONE; TRIPTORELIN; UNCLASSIFIED DRUG; HMG IBSA; HMG-IBSA;

ABDOMINAL PAIN; ADULT; ARTICLE; BIOEQUIVALENCE; CLINICAL EFFECTIVENESS; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG EFFICACY; DRUG RESPONSE; DRUG SAFETY; DRUG TOLERABILITY; FEMALE; FEMALE INFERTILITY; FERTILIZATION IN VITRO; HEADACHE; HUMAN; INJECTION SITE PAIN; MAJOR CLINICAL STUDY; MULTICENTER STUDY; OOCYTE DEVELOPMENT; OVARY HYPERSTIMULATION; OVULATION INDUCTION; PHASE 3 CLINICAL TRIAL; PREGNANCY OUTCOME; PREGNANCY RATE; RANDOMIZED CONTROLLED TRIAL; TREATMENT OUTCOME; INTRAMUSCULAR DRUG ADMINISTRATION; METHODOLOGY; PREGNANCY; SUBCUTANEOUS DRUG ADMINISTRATION;

ADULT; FEMALE; FERTILIZATION IN VITRO; HUMANS; INJECTIONS, INTRAMUSCULAR; INJECTIONS, SUBCUTANEOUS; MENOTROPINS; OVULATION INDUCTION; PREGNANCY; PREGNANCY RATE; TREATMENT OUTCOME;

EID: 38749142594     PISSN: None     EISSN: 14777827     Source Type: Journal    
DOI: 10.1186/1477-7827-5-45     Document Type: Article

References (21)

1. Stouffer RL Zelinski-Wooten MB Overriding follicle selection in controlled ovarian stimulation protocols: Quality vs quantity Reprod Biol Endocrinol 2004, 16:2-32.
2. Cohen J A short review of ovarian stimulation in assisted reproductive techniques Reprod Biomed Online 2003, 6:361-366. 12735875
3. Giudice E Crisci C Eshkol A Papoian R Composition of commercial gonadotrophin preparations extracted from human post-menopausal urine: characterization of non-gonadotrophin proteins Hum Reprod 1994, 9:2291-2299. 7714147
4. Van de Weijer BH Mulders JW Bos ES Verhaert PD Van den Hooven HW Compositional analyses of a human menopausal gonadotrophin preparation extracted from urine (menotrophin). Identification of some of its major impurities Reprod Biomed Online 2003, 7:547-557. 14680547
5. Fleming R Chung CC Yates RW Coutts JR Purified urinary follicle stimulating hormone induces different hormone profiles compared with menotrophins, dependent upon the route of administration and endogenous luteinizing hormone activity Hum Reprod 1996, 11:1854-1858. 8921053
6. Lispi M Bassett R Crisci C Mancinelli M Martelli F Ceccarelli D De Bellis C Mendola D Comparative assessment of the consistency and quality of a highly purified FSH extracted from human urine (urofollitropin) and a recombinant human FSH (follitropin alpha) Reprod Biomed Online 2006, 13:179-193. 16895630
7. Palagiano A Nesti E Pace L FSH: Urinary and recombinant Eur J Obstet Gynecol Reprod Biol 2004 115 (Suppl 1):S30-33. 10.1016/ j.ejogrb.2004.01.023 15196713
8. Gordon K New developments in gonadotrophin pharmacology Reprod Biomed Online 2002, 5:259-264. 12470523
9. Al-Inany HG Abou-Setta AM Aboulghar MA Mansour RT Serour GI HMG versus rFSH for ovulation induction in developing countries: A cost-effectiveness analysis based on the results of a recent meta-analysis Reprod Biomed Online 2006, 12:163-169. 16478578
10. Al-Inany H Aboulghar M Mansour R Serour G Meta-analysis of recombinant versus urinary-derived FSH: An update Hum Reprod 2003, 18:305-313. 10.1093/humrep/deg088 12571166
11. Al-Inany H Aboulghar MA Mansour RT Serour GI Ovulation induction in the new millennium: Recombinant follicle-stimulating hormone versus human menopausal gonadotropin Gynecol Endocrinol 2005, 20:161-169. 10.1080/ 09513590400027232 16019356
12. Daya S Gunby J Recombinant versus urinary follicle stimulating hormone for ovarian stimulation in assisted reproduction cycles Cochrane Database Syst Rev 2000, 4:CD002810. 11034767
13. Van Wely M Westergaard LG Bossuyt PM Van der Veen F Human menopausal gonadotropin versus recombinant follicle stimulation hormone for ovarian stimulation in assisted reproductive cycles Cochrane Database Syst Rev 2003, 1:CD003973. 12535497
14. Ubaldi F Rienzi L Ferrero S Baroni E Iacobelli M Sapienza F Minasi MG Cobellis L Romano S Scarselli F Greco E Natural in vitro fertilization cycles Ann N Y Acad Sci 2004, 1034:245-251. 10.1196/annals.1335.026 15731316
15. Loutradis D Kiapekou E Zapanti E Antsaklis A Oocyte maturation in assisted reproductive techniques Ann N Y Acad Sci 2006, 1092:235-246. 10.1196/annals.1365.020 17308148
16. Gilchrist RB Thompson JG Oocyte maturation: Emerging concepts and technologies to improve developmental potential in vitro Theriogenology 2007, 67:6-15. 10.1016/j.theriogenology.2006.09.027 17092551
17. Tan SL Child TJ In-vitro maturation of oocytes from unstimulated polycystic ovaries Reprod Biomed Online 2002, 4(Suppl 1):18-23. 12470331
18. Sedbon E Wainer R Perves C Quality of life of patients undergoing ovarian stimulation with injectable drugs in relation to medical practice in France Reprod Biomed Online 2006, 12:298-303. 16569316
19. Voortman G Mannaerts BM Huisman JA A dose proportionality study of subcutaneously and intramuscularly administered recombinant human follicle-stimulating hormone (Follistim*/Puregon) in healthy female volunteers Fertil Steril 2000, 73:1187-1193. 10.1016/ S0015-0282(00)00542-2 10856481
20. Huisman JA Paulussen RJ Geurts TB Odink J Rekers H Assessment of bioequivalence after subcutaneous and intramuscular administration of urinary gonadotrophins Hum Reprod 1997, 12:34-38. 10.1093/humrep/12.1.34 9043898
21. Ebner T Moser M Tews G Is oocyte morphology prognostic of embryo developmental potential after ICSI? Reprod Biomed Online 2006, 12:507-512. 16740226