Cardiovascular effect of Capparis spinosa aqueous extract. Part III: Antihypertensive effect in spontaneously hypertensive rats

American Journal of Pharmacology and Toxicology

Volumn 2, Issue 3, 2007, Pages 111-115

  Zeggwagh, Naoufel Ali ^a   Eddouks, Mohamed ^a   Michel, Jean Baptiste ^b   Sulpice, Thierry ^c   Hajji, Lhoussain ^a  

^a MOULAY ISMAIL UNIVERSITY   (Morocco)

^b INSERM   (France)

^c Physiogenex   (France)

Author keywords

Aqueous extract; Blood pressure; Diuretic activity; Renin angiotensin system

Indexed keywords

ALPHA 1 ADRENERGIC RECEPTOR; CALCIUM CHANNEL; CAPPARIS SPINOSA EXTRACT; HERBACEOUS AGENT; NITRIC OXIDE; NORADRENALIN; POTASSIUM CHLORIDE; PROSTAGLANDIN SYNTHASE; UNCLASSIFIED DRUG; VOLTAGE DEPENDENT ANION CHANNEL;

ADRENERGIC RECEPTOR BLOCKING; ANIMAL TISSUE; AQUEOUS SOLUTION; ARTICLE; CAPPARIS; CAPPARIS SPINOSA; CARDIOVASCULAR EFFECT; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENDOTHELIUM; ENZYME INHIBITION; IN VITRO STUDY; NONHUMAN; RAT; RECEPTOR BLOCKING; VASCULAR RING; VASODILATATION;

CAPPARIS SPINOSA; RATTUS;

EID: 38749134858     PISSN: 15574962     EISSN: 15574970     Source Type: Journal    
DOI: 10.3844/ajptsp.2007.111.115     Document Type: Article

References (17)

1. Caceres, A., L.M. Giron and A.M Martinez, 1987. Diuretic activity of plants used for the treatment of urinary ailments in guatemala. J. Ethnopharmacol., 19 (3): 233- 245.
2. Zamboli, P., L. De Nicola, R. Minutolo, V. Bertino, F. Catapano and G. Conte, 2006. Management of hypertension in chronic kidney disease. Curr. Hypertens. Rep., 8 (6): 497-501.
3. Eddouks, M., M. Maghrani, N.A. Zeggwagh, M. Haloui and J.B. Michel, 2005. Fraxinus excelsior L. evokes a hypotensive action in normal and spontaneously hypertensive rats. J. Ethnopharmacol., 99 (1): 49-54.
4. Herrera-Arellano, A., J. Miranda-Sanchez, P. Avila-Castro, S. Herrera-Alvarez, J.E. Jimenez-Ferrer, A. Zamilpa, R. Roman-Ramos, H. Ponce-Monter and J. Tortoriello, 2007. Clinical effects produced by a standardized herbal medicinal product of Hibiscus sabdariffa on patients with hypertension. A randomized, double-blind, lisinopril-controlled clinical trial. Planta. Med., 73 (1): 612.
5. Inokuchi, J., H. Okabe, T. Yamauchi, A. Nagamatsu, G. Nonaka and I. Nishioka, 1986. Antihypertensive substance in seeds of Areca catechu L. Life. Sci., 38 (15): 1375-1382.
6. Eddouks, M., M. Maghrani, A. Lemhadri, M.L. Ouahidi and H. Jouad, 2002. Ethnopharmacological survey of medicinal plants used for the treatment of diabetes mellitus, hypertension and cardiac diseases in the south-east region of Morocco (Tafilalet). J. Ethnopharmacol., 82 (2-3): 97-103.
7. Cushman, D.W and H.S. Cheung, 1971. Spectrophotometric assay and propreties of the angiotensin-converting enzyme of rabbit. Lung. Biochem. Pharmacol., 20 (7): 1637-1648.
8. Freildland, J and E. Silverstein, 1976. A sensitive fluorimetric assay for serum angiotensinconverting enzyme. A. J. Clin. Path., 66 (2): 416-424.
9. Rates, S.M.K., 2001. Plants as source of drugs. Toxicon, 39: 603-613.
10. Bakris, G.L and G.A. Mensah, 2003. Pathogenesis and clinical physiology of hypertension. Cur. Prob. Cardiol., 28 (2): 137- 155.
11. Michel, J.B., 2004. Renin angiotensine-system and vascular remodeling. Med. Sci., 20 (4): 409-413.
12. Maghrani, M., N.A. Zeggwagh, A. Lemhadri, M. El Amraoui, J.B. Michel and M. Eddouks, 2004. Study of the hypoglycaemic activity of Fraxinus excelsior and Silybum marianum in an animal model of type 1 diabetes mellitus. J. Ethnopharmacol., 91 (2-3): 309-316.
13. Maghrani, M., N.A. Zeggwagh, J.B. Michel and M. Eddouks, 2005. Antihypertensive effect of Lepidium sativum L. in spontaneously hypertensive rats. J. Ethnopharmacol., 100 (1-2): 193-197.
14. Hattori, T and P.L. Wang, 2006. Involvement of Na(+)-K(+)-2Cl(-) cotransporters in hypertonicity-induced rise in intracellular calcium concentration. Int. J. Neurosci., 116 (12): 1501-1507.
15. Haloui, M., L. Louedec, J.B. Michel and B. Lyoussi, 2000. Experimental diuretic effects of Rosmarinus officinalis and Centaurium erythraea. Journal of Ethnopharmacology, 71 (3): 465-472.
16. Lerman, L.O., A.R. Chade, V. Sica and C. Napoli, 2005. Animal models of hypertension: An overview. Journal of Laboratory and Clinical Medecine, 146 (3): 160-169.
17. Liu, J.C., F.L. Hsu, J.C. Tsai, P. Chan, J.Y. Liu, G.N. Thomas, B. Tomlinson, M.Y. Lo and J.Y. Lin, 2003. Antihypertensive effects of tannins isolated from traditional Chinese herbs as nonspecific inhibitors of angiontensin converting enzyme. Life. Sci., 73 (12): 1543-1555.