Diverse signalling mechanisms used by relaxin in natural cells and tissues: The evolution of a "neohormone"

Advances in Experimental Medicine and Biology

Volumn 612, Issue , 2007, Pages 26-33

  Ivell, Richard ^a   Heng, Kee ^a   Anand Ivell, Ravinder ^a  

^a UNIVERSITY OF ADELAIDE   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

ADENYLATE CYCLASE; CYCLIC AMP; G PROTEIN COUPLED RECEPTOR; GLUCOCORTICOID RECEPTOR; HORMONE; LGR7; METALLOPROTEINASE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE C ZETA; PROTEIN TYROSINE KINASE; RELAXIN; TISSUE INHIBITOR OF METALLOPROTEINASE; UNCLASSIFIED DRUG; LGR7 PROTEIN, HUMAN; MEMBRANE PROTEIN; PROTEIN KINASE C;

ANGIOGENESIS; CALCIUM TRANSPORT; CELL DIFFERENTIATION; CYTOPLASM; ENDOCRINE SYSTEM; ENZYME ACTIVATION; ENZYME ACTIVITY; GENE DUPLICATION; HUMAN; LACTATION; MESENCHYME CELL; MOLECULAR EVOLUTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVIEW; SECOND MESSENGER; SIGNAL TRANSDUCTION; TISSUE REPAIR; VASODILATATION; VIVIPARITY; WOUND HEALING; ANIMAL; BIOSYNTHESIS; FEMALE; GENETIC TRANSCRIPTION; GENETICS; MALE; METABOLISM; PHYSIOLOGY;

MAMMALIA;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ADENYLATE CYCLASE; ANIMALS; CYCLIC AMP; EVOLUTION, MOLECULAR; FEMALE; HUMANS; LACTATION; MALE; MEMBRANE PROTEINS; PROTEIN KINASE C; PROTEIN-TYROSINE KINASES; RECEPTORS, G-PROTEIN-COUPLED; RECEPTORS, GLUCOCORTICOID; RELAXIN; SECOND MESSENGER SYSTEMS; TRANSCRIPTION, GENETIC; VIVIPARITY, NONMAMMALIAN; WOUND HEALING;

EID: 38749133386     PISSN: 00652598     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-0-387-74672-2_3     Document Type: Review

References (20)

1. Ivell R, Bathgate RAD. Hypothesis: Neohormone systems as exciting targets for drug development. Trends Endocrinol Mctab 2006; 17:123.
2. Bathgate RA, Hsueh AJ, Ivell R et al. International Union of Pharmacology. Recommendations for the nomenclature of receptors for relaxin family peptides. Pharmacol Rev 2006; 58:7-31.
3. Wilkinson TN, Speed TP, Tregear GW et al. Evolution of the relaxin-like peptide family. BMC Evol Biol 2005; 5:14.
4. Mazerbourg S, Bouley DM, Sudo S et al. Leucine-rich repeat-containing G protein-coupled receptor 4 null mice exhibit intrauterine growth retardation associated with embryonic and perinatal lethality. Mol Endocrinol 2004; 18:2241-2254.
5. Halls ML, Bathgate RA, Summers RJ. Comparison of signalling pathways activated by the relaxin family peptide receptors, RXFP1 and RXFP2, revealed using reporter genes. J Pharmacol Exp Ther 2006; (epub ahead of print).
6. Fei DT, Gross MC, Lofgren JL et al. 1990. Cyclic AMP response to recombinant human relaxin by cultured human endometrial cells - a specific and high throughput in vitro bioassay. Biochem Biophys Res Commun 1990; 170:214-222.
7. Bartsch O, Bartlick B, Ivell R. Relaxin signalling links tyrosine phosphorylation to phosphodiesterase and adenylyl cyclase activity. Mol Hum Reprod 2001; 7:799-809.
8. Bartsch O, Bartlick B, Ivell R. Phosphodiesterase 4 inhibition synergizes with relaxin signalling to promote decidualization of human endometrial stromal cells. J Clin Endocrinol Metab 2004; 89:324-334.
9. Halls ML, Bathgate RA, Summers RJ. Relaxin family peptide receptors RXFP1 and RXFP2 modulate cAMP signalling by distinct mechanisms. Mol Pharmacol 2006; 70:214-226.
10. Nguyen BT, Yang L, Sanborn BM et al. Phosphoinositide 3-kinase activity is required for biphasic stimulation of cyclic adenosine 3′,5′- monophosphate by relaxin. Mol Endocrinol 2003; 17:1075-1084.
11. Nguyen BT, Dessauer CW. Relaxin stimulates protein kinase C zeta translocation: requirement for cyclic adenosine 3′,5′-monophosphate production. Mol Endocrinol 2005; 19:1012-1023.
12. Kalbag SS, Roginsky MS, Jelveh Z et al. Phorbol ester, prolactin and relaxin cause translocation of protein kinase C from cytosol to membranes in human endometrial cells. Biochim Biophys Acta 1991; 1094:85-91.
13. Bartsch O, Bartlick B, Ivell R. Relaxin signal transduction couples tyrosine phosphorylation to cAMP upregulation. In: Tregear GW, Ivell R, Bathgate RAD, Wade JD, eds. Relaxin 2000: Proceedings of the 3rd International Conference on Relaxin and Related Peptides. Kluwer Academic Publishers; Dordrecht, Netherlands 2001; 309-316.
14. Mayerhofer A, Engling R, Stecher B et al. Relaxin triggers calcium transients in human granulosa-lutein cells. Eur J Endocrinol 1995; 132:507-513.
15. Dschietzig T, Bartsch C, Stangl V et al. Identification of the pregnancy hormone relaxin as glucocorticoid receptor agonist. FASEB J 2004; 18:1536-1538.
16. Dodge KL, Sanborn BM. Evidence for inhibition by protein kinase A of receptor/G alpha(q)/phospholipase C (PLC) coupling by a mechanism not involving PLCbeta2. Endocrinology 1998; 139:2265-2271.
17. Ivell R, Balvers M, Pohnke Y et al. Immunoexpression of the relaxin receptor LGR7 in breast and uterine tissues of humans and primates. Reprod Biol Endocrinol 2003; 1:114.
18. Downing SJ, Hollingsworth M. Action of relaxin on uterine contraction - a review. J Reprod Fertil 1993; 99:275-282.
19. Ivell R, Einspanier A. Relaxin peptides are new global players. Trends Endocrinol Metab 2002; 13:343-348.
20. Anand-Ivell R, Heng K, Ivell R. Relaxin signaling in THP-1 cells uses a novel phospholyrosine-dependent pathway. Mol Cell Endocrinol 2007; (in press).