Treatment of Renal Transplant Recipients With Low Bone Mineral Density: A Randomized Prospective Trial of Alendronate, Alfacalcidol, and Alendronate Combined With Alfacalcidol

Transplantation Proceedings

Volumn 40, Issue 1, 2008, Pages 160-166

  Trabulus, S ^a   Altiparmak, M R ^b   Apaydin, S ^b   Serdengecti, K ^b   Sariyar, M ^b  

^a ISTANBUL TRAINING AND RESEARCH HOSPITAL   (Turkey)

^b ISTANBUL UNIVERSITY   (Turkey)

Author keywords

[No Author keywords available]

Indexed keywords

ALENDRONIC ACID; ALFACALCIDOL;

ADULT; ANALYSIS OF VARIANCE; ARTICLE; BONE DENSITY; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG EFFICACY; FEMALE; FEMUR NECK; HUMAN; KIDNEY GRAFT; KRUSKAL WALLIS TEST; MAJOR CLINICAL STUDY; MALE; OSTEOPOROSIS; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RISK FACTOR;

ALENDRONATE; BONE DENSITY; BONE DENSITY CONSERVATION AGENTS; CREATININE; DRUG THERAPY, COMBINATION; FEMALE; HUMANS; HYDROXYCHOLECALCIFEROLS; KIDNEY FAILURE, CHRONIC; KIDNEY TRANSPLANTATION; MALE; PATIENT SELECTION; TRANSPLANTATION, HOMOLOGOUS;

EID: 38749129649     PISSN: 00411345     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.transproceed.2007.12.001     Document Type: Article

References (22)

1. Julian B.A., Laskow D.A., Dubovsky J., et al. Rapid loss of vertebral mineral density after renal transplantation. N Engl J Med 325 (1991) 544
2. Torregrosa J.V., Campistol J.M., Montesinos M., et al. Factors involved in the loss of bone mineral density after renal transplantation. Transplant Proc 27 (1995) 2224
3. Grotz W.H., Mundinger F.A., Gugel B., et al. Bone mineral density after kidney transplantation. A cross-sectional study in 190 graft recipients up to 20 years after transplantation. Transplantation 59 (1995) 982
4. Braun W.E. The medical management of the renal transplant recipient. In: Johnson R.J., and Feehally J. (Eds). Comprehensive Clinical Nephrology. 2nd Ed. (2003), Mosby, London 1105
5. Trabulus S., Apaydin S., Altiparmak M.R., et al. Osteoporosis after renal transplantation. Nefrologia 23 suppl 1 (2003) 126
6. Kanis J.A. Assessment of fracture risk and its application to screening for postmenopausal osteoporosis: synopsis of a WHO report. WHO Study Group. Osteoporos Int 4 (1994) 368
7. Drüeke T.B., and Lacour B. Disorders of calcium, phosphate, and magnesium metabolism. In: Johnson R.J., and Feehally J. (Eds). Comprehensive Clinical Nephrology. 2nd Ed. (2003), Mosby, London 123
8. Sperschneider H., and Stein G. Bone disease after renal transplantation. Nephrol Dial Transplant 8 (2003) 874
9. Plotkin L.I., Weinstein R.S., Parfitt A.M., et al. Prevention of osteocyte and osteoblast apoptosis by bisphosphonates and calcitonin. J Clin Invest 104 (1999) 1363
10. Brandenburg V.M., Westenfeld R., and Ketteler M. The fate of bone after renal transplantation. J Nephrol 17 (2004) 190
11. Cruz D.N., Brickel H.M., Wysolmerski J.J., et al. Treatment of osteoporosis and osteopenia in long-term renal transplant patients with alendronate. Am J Transplant 2 (2002) 62
12. Jeffery J.R., Leslie W.D., Karpinski M.E., et al. Prevalence and treatment of decreased bone density in renal transplant recipients: a randomized prospective trial of calcitriol versus alendronate. Transplantation 76 (2003) 1498
13. Koc M., Tuglular S., Arikan H., et al. Alendronate increases bone mineral density in long-term renal transplant recipients. Transplant Proc 34 (2002) 2111
14. El-Agroudy A.E., El-Husseini A.A., El-Sayed M., et al. A prospective randomized study for prevention of postrenal transplantation bone loss. Kidney Int 67 (2005) 2039
15. Montalban C., de Francisco A.L., Marinoso M.L., et al. Bone disease in long-term adult kidney transplant patients with normal renal function. Kidney Int Suppl 85 (2003) S129
16. El-Agroudy A.E., El-Husseini A.A., El-Sayed M., et al. Preventing bone loss in renal transplant recipients with vitamin D. J Am Soc Nephrol 14 (2003) 2975
17. De Sevaux R.G.L., Hoitsma A.J., Corstens F.H.M., et al. Treatment with vitamin D and calcium reduces bone loss after renal transplantation: a randomized study. J Am Soc Nephrol 13 (2002) 1608
18. Berczi C., Asztalos L., Kincses Z., et al. Comparison of calcium and alfacalcidol supplement in the prevention of osteopenia after kidney transplantation. Osteoporos Int 14 (2003) 412
19. Giannini S., D'Angelo A., Carraro G., et al. Alendronate prevents further bone loss in renal transplant recipients. J Bone Miner Res 16 (2001) 2111
20. Coco M., Glicklich D., Faugere M.C., et al. Prevention of bone loss in renal transplant recipients: a prospective, randomized trial of intravenous pamidronate. J Am Soc Nephrol 14 (2003) 2669
21. Kovac D., Lindic J., Kandus A., et al. Prevention of bone loss in kidney graft recipients. Transplant Proc 33 (2001) 1144
22. Bellorin-Font E., Rojas E., Carlini R.G., et al. Bone remodeling after renal transplantation. Kidney Int Suppl 85 (2003) S125