Hepatoselectivity of statins: Design and synthesis of 4-sulfamoyl pyrroles as HMG-CoA reductase inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 18, Issue 3, 2008, Pages 1151-1156

  Park, William K C ^a   Kennedy, Robert M ^a   Larsen, Scott D ^a   Miller, Steve ^a   Roth, Bruce D ^a   Song, Yuntao ^a   Steinbaugh, Bruce A ^a   Sun, Kevin ^a   Tait, Bradley D ^a   Kowala, Mark C ^a   Trivedi, Bharat K ^a   Auerbach, Bruce ^a   Askew, Valerie ^a   Dillon, Lisa ^a   Hanselman, Jeffrey C ^a   Lin, Zhiwu ^a   Lu, Gina H ^a   Robertson, Andrew ^a   Sekerke, Catherine ^a  

^a PFIZER INC   (United States)

Author keywords

Atorvastatin; C log P; Hepatocytes; HMG CoA reductase; Hydrophilicity; L6 myocytes; LDL C; Lipophilicity; Organic anion transporting polypeptides; Rosuvastatin

Indexed keywords

ATORVASTATIN; CHOLESTEROL; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; PYRROLE DERIVATIVE; ROSUVASTATIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; CYCLOADDITION; DRUG ACTIVITY; DRUG IDENTIFICATION; DRUG POTENCY; DRUG SELECTIVITY; DRUG SYNTHESIS; LIVER; MUSCLE CELL; NONHUMAN; RAT;

ANIMALS; COMBINATORIAL CHEMISTRY TECHNIQUES; DISEASE MODELS, ANIMAL; FLUOROBENZENES; HEPATOCYTES; HEPTANOIC ACIDS; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; MICE; MOLECULAR STRUCTURE; MUSCLE CELLS; PYRIMIDINES; PYRROLES; SULFONAMIDES;

EID: 38749124743     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2007.11.124     Document Type: Article

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