Update on immunosuppressive drugs used in solid-organ transplantation and their nutrition implications

Nutrition in Clinical Practice

Volumn 22, Issue 5, 2007, Pages 467-473

  McPartland, Kenneth J ^a   Pomposelli, James J ^a  

^a LAHEY HOSPITAL AND MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 CYANO 3 HYDROXY N [4 (TRIFLUOROMETHYL)PHENYL] 6 HEPTYNAMIDE; ALEMTUZUMAB; ANTIEMETIC AGENT; AZATHIOPRINE; BASILIXIMAB; BELATACEPT; CALCINEURIN INHIBITOR; CORTICOSTEROID DERIVATIVE; CYCLOSPORIN; CYCLOSPORIN A; DACLIZUMAB; EVEROLIMUS; FINGOLIMOD; FLUDROCORTISONE; FLUDROCORTISONE ACETATE; HYDROCORTISONE; IMMUNOSUPPRESSIVE AGENT; INSULIN; LEFLUNOMIDE; MAGNESIUM OXIDE; MEGESTROL ACETATE; METHYLPREDNISOLONE; MYCOPHENOLIC ACID; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; NONSTEROID ANTIINFLAMMATORY AGENT; OKT 3; OMEGA 3 FATTY ACID; PREDNISONE; RAPAMYCIN; TACROLIMUS; THYMOCYTE ANTIBODY;

ACUTE GRAFT REJECTION; ALOPECIA; ANOREXIA; AVASCULAR NECROSIS; BONE MARROW SUPPRESSION; CATARACTOGENESIS; CONTINUOUS INFUSION; DIABETES MELLITUS; DIARRHEA; DIET THERAPY; DRUG BINDING; DRUG BLOOD LEVEL; DRUG FEVER; DRUG HALF LIFE; DRUG INHIBITION; DRUG MECHANISM; DRUG MEGADOSE; DRUG METABOLISM; DRUG PROTEIN BINDING; ELECTROLYTE DISTURBANCE; FOOD DRUG INTERACTION; GASTROINTESTINAL SYMPTOM; GINGIVA HYPERPLASIA; HEADACHE; HIRSUTISM; HUMAN; HYPERCHOLESTEROLEMIA; HYPERGLYCEMIA; HYPERKALEMIA; HYPERLIPIDEMIA; HYPERPHAGIA; HYPERTENSION; HYPERTRIGLYCERIDEMIA; HYPOMAGNESEMIA; IMMUNE SYSTEM; IMMUNOPROPHYLAXIS; IMMUNOSUPPRESSIVE TREATMENT; INFECTION; LEUKOPENIA; LIVER TOXICITY; LOW DRUG DOSE; MOON FACE; MOUTH ULCER; MUSCLE ATROPHY; NAUSEA; NEPHROTOXICITY; NEUROTOXICITY; NUTRITIONAL STATUS; NUTRITIONAL SUPPORT; ORGAN TRANSPLANTATION; OSTEOPOROSIS; PEPTIC ULCER; PERIPHERAL EDEMA; PERSONALITY; PNEUMONIA; POTASSIUM RESTRICTION; REVIEW; SEIZURE; SIDE EFFECT; SODIUM RETENTION; SORE THROAT; TASTE DISORDER; TREMOR; UNSPECIFIED SIDE EFFECT; VOMITING; WEIGHT GAIN; WOUND HEALING IMPAIRMENT; DRUG EFFECT; GRAFT REJECTION; NUTRITION; PHYSIOLOGY; RISK FACTOR; TIME;

GRAFT REJECTION; HUMANS; IMMUNOSUPPRESSIVE AGENTS; NUTRITION PHYSIOLOGY; NUTRITIONAL STATUS; ORGAN TRANSPLANTATION; RISK FACTORS; TIME FACTORS;

EID: 38749123536     PISSN: 08845336     EISSN: None     Source Type: Journal    
DOI: 10.1177/0115426507022005467     Document Type: Review

References (27)

1. Starzl TE. The mystique of organ transplantation. J Am Coll Surg. 2005;201:160-170.
2. Lin S, Cosgrove CJ. Perioperative management of immunosuppression. Surg Clin North Am. 2006;86:1167-1183.
3. Kneteman NM. Steroid-free immunosuppression: balancing efficacy and toxicity. Liver Transpl. 2001;7:698-700.
4. Hasse JM. Nutrition assessment and support of organ transplant recipients. JPEN J Parenter Enteral Nutr. 2001;25:120-131.
5. Hale DA. Basic transplantation immunology. Surg Clin North Am. 2006;86:1103-1125.
6. Halloran PF, Gourishankar S. Principles and overview of immunosuppression. In: Norman DJ, Turka LA, eds. Primer on Transplantation. 2nd ed. Mount Laurel, NJ: American Society of Transplantation; 2001:87-98.
7. Czock D, Keller F, Rasche FM, Haussler U. Pharmacokinetics and pharmacodynamics of systemically administered glucocorticoids. Clin Pharmacokinet. 2005;44:61-98.
8. Granger D, Domenick M, Ildstad S. Transplantation immunology and immunosuppression. In: Townsend CM, Beauchamp R, Evers B, Mattox K, eds. Sabiston Textbook of Surgery: The Biological Basis of Modern Surgical Practice. 17th ed. Philadelphia, PA: Saunders; 2004:665-697.
9. Greig P, Lilly L, Scudamore C, et al. Early steroid withdrawal after liver transplantation: the Canadian Tacrolimus Versus Microemulsion Cyclosporin A Trial: 1-year follow-up. Liver Transpl. 2003;9:587-595.
10. Jaber JJ, Feustel PJ, Elbahloul O, Conti AD, Gallichio MH, Conti DJ. Early steroid withdrawal therapy in renal transplant recipients: a steroid-free sirolimus and CellCept-based calcineurin inhibitor-minimization protocol. Clin Transplant. 2007;21:101-109.
11. Vriesendorp TM, Morelis QJ, Devries JH, Legemate DA, Hoekstra JB. Early post-operative glucose levels are an independent risk factor for infection after peripheral vascular surgery: a retrospective study. Eur J Vasc Endovasc Surg. 2004;28:520-525.
12. Pomposelli JJ, Baxter JK, Babineau TJ, et al. Early postoperative glucose control predicts nosocomial infection rate in diabetic patients. JPEN J Parenter Enteral Nutr. 1998;22:77-81.
13. Latham R, Lancaster AD, Covington JF, Pirolo JS, Thomas CS. The association of diabetes and glucose control with surgical-site infections among cardiothoracic surgery patients. Infect Control Hosp Epidemiol. 2001;22:607-612.
14. van den Berghe G, Wouters P, Weekers F, et al. Intensive insulin therapy in the critically ill patients. N Engl J Med. 2001;345:1359-1367.
15. Levy G, Thervet E, Lake J, Uchida K. Patient management by Neoral C(2) monitoring: an international consensus statement. Transplantation. 2002;73(Suppl 9):S12-S18.
16. Stratta P, Canavese C, Quaglia M, et al. Posttransplantation chronic renal damage in nonrenal transplant recipients. Kidney Int. 2005;68:1453-1463.
17. Kahan BD, Camardo JS. Rapamycin: clinical results and future opportunities. Transplantation. 2001;72:1181-1193.
18. Kahan BD. Sirolimus-based immunosuppression: present state of the art. J Nephrol. 2004;17(Suppl 8):S32-S39.
19. Davidson MH. Mechanisms for the hypertriglyceridemic effect of marine omega-3 fatty acids. Am J Cardiol. 2006;98:27-33.
20. Grim SA, Slover CM, Sankary H, Oberholzer J, Benedetti E, Clark NM. Risk factors for wound healing complications in sirolimus-treated renal transplant recipients. Transplant Proc. 2006;38:3520-3523.
21. Knight RJ, Kahan BD. The place of sirolimus in kidney transplantation: can we reduce calcineurin inhibitor renal toxicity? Kidney Int. 2006;70:994-999.
22. Chan M, Pearson GJ. New advances in antirejection therapy. Curr Opin Cardiol. 2007;22:117-122.
23. Gautam A. Gastrointestinal complications following transplantation. Surg Clin North Am. 2006;86:1195-1206.
24. Knoll GA, MacDonald I, Khan A, Van Walraven C. Mycophenolate mofetil dose reduction and the risk of acute rejection after renal transplantation. J Am Soc Nephrol. 2003;14:2381-2386.
25. Hasse J. Nutritional aspects of adult liver transplantation. In: Busuttil RW, Klintmalm GB, eds. Transplantation of the Liver. 2nd ed. Philadelphia, PA: Elsevier Saunders; 2005:491-505.
26. Yopp AC, Ledgerwood LG, Ochando JC, Bromberg JS. Sphingosine 1-phosphate receptor modulators: a new class of immunosuppressants. Clin Transpl. 2006;20:788-795.
27. Larsen CP, Knechtle SJ, Adams A, Pearson T, Kirk AD. A new look at blockade of T-cell costimulation: a therapeutic strategy for long-term maintenance immunosuppression. Am J Transplant. 2006;6:876-883.