Clomiphene citrate for treatment refractory chronic cluster headache

Headache

Volumn 48, Issue 2, 2008, Pages 286-290

  Rozen, Todd ^a  

^a Michigan Head Pain and Neurological Institute   (United States)

Author keywords

Clomiphene citrate; Cluster headache; Headache; Suprachiasmatic nucleus; Testosterone; Trigeminal autonomic cephalalgias

Indexed keywords

BACLOFEN; CLOMIFENE CITRATE; CLONIDINE; DIHYDROERGOTAMINE; ETIRACETAM; FROVATRIPTAN; GABAPENTIN; INDOMETACIN; LAMOTRIGINE; LITHIUM; MEMANTINE; METHYSERGIDE; MIRTAZAPINE; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; NARATRIPTAN; NIMODIPINE; OLANZAPINE; OPIATE; OXCARBAZEPINE; PREDNISONE; PREGABALIN; RAMELTEON; SUMATRIPTAN; TIZANIDINE; TOPIRAMATE; VALPROIC ACID; VERAPAMIL;

ADULT; AGITATION; ARTICLE; CASE REPORT; CHRONIC CLUSTER HEADACHE; CIGARETTE SMOKING; DRUG COST; DRUG DOSE INCREASE; DRUG MECHANISM; HEALTH INSURANCE; HUMAN; LACRIMATION; MAGNETIC RESONANCE ANGIOGRAPHY; MALE; NEUROIMAGING; PAIN; PRIORITY JOURNAL; PTOSIS; RHINORRHEA; SUNCT SYNDROME; TESTOSTERONE BLOOD LEVEL; TRIGEMINAL AUTONOMIC CEPHALALGIA;

ADULT; CLOMIPHENE; CLUSTER HEADACHE; ESTROGEN ANTAGONISTS; HUMANS; MALE;

EID: 38749119380     PISSN: 00178748     EISSN: 15264610     Source Type: Journal    
DOI: 10.1111/j.1526-4610.2007.00995.x     Document Type: Article

References (19)

1. May A, Bahra A, Buchelk C, Frackwiak RS, Goadsby PJ. Hypothalamic activation in cluster headache attacks. Lancet. 1998 352 : 275 278.
2. Matharu M, Cohen AS, McGonigle DJ, et al. Posterior hypothalamic and brainstem acivation in hemicrania continua. Headache. 2004 44 : 747 761.
3. May A, Bahra A, Buchel C, Turner R, Goadsby PJ. Functional magnetic resonance imaging in spontaneous attacks of SUNCT. Short-lasting neuralgiform headache with conjunctival injection and tearing. Ann Neurol. 1999 46 : 791 794.
4. Peres MFP, Rozen TD. Melatonin in the preventive treatment of chronic cluster headache. Cephalalgia. 2001 21 : 993 995.
5. Leone M, Franzini A, Broggi G, Bussone G. Hypothalamic stimulation for intractable cluster headache: Long-term experience. Neurology. 2006 67 : 150 152.
6. Rozen TD, Saper JR, Sheftell FD, Dodick DW. Clomiphene citrate as a new treatment for SUNCT (hormonal manipulation for hypothalamic influenced trigeminal autonomic cephalalgias). Headache. 2005 45 : 754 756.
7. Leone M, Bussone G. A review of hormonal findings in cluster headache. Evidence for hypothalamic involvement. Cephalalgia. 1993 13 : 309 317.
8. Nicolodi M, Sicuteri F, Poggioni M. Hypothalamic modulation of nociception and reproduction in cluster headache. II. Testosterone-induced increase of sexual activity in males with cluster headache. Cephalalgia. 1993 13 : 258 260.
9. Stillman MJ. Testosterone replacement therapy for treatment refractory cluster headache. Headache. 2006 46 : 925 933.
10. Nicolodi M, Sicuteri F, Poggioni M. Hypothalamic modulation modulation of nociception and reproduction in cluster headache I. Therapeutic trials of leuprolide. Cephalalgia. 1993 13 : 253 257.
11. Adashi EY. Clomiphene citrate: Mechanism and sites of action-hypothesis revisted. Fertil Steril. 1984 42 : 331 344.
12. Chaube SK, Prasad PV, Tripathy V, Shrivastav TG. Clomiphene citrate inhibits gonadotropin-induced ovulation by reducing cyclic adenosine 3,5'-cyclic monophosphate and prostaglandin E2 levels in rat ovary. Fertil Steril. 2006 86(Suppl 4) : 1106 1111.
13. Neulen J, Zahradnik HP, Flecken U, Breckwoldt M. The effect of clomiphene on the synthesis of prostaglandins (PGF2 alpha, PGE2, PGI2) in human endometrial cells in vitro with and without addition of estradiol-17 beta or progesterone. Prostaglandins Leukot Essent Fatty Acids. 1989 35 : 131 134.
14. Nattero G, Franzone JS, Savi L, Cirillo R. Serum prostaglandin-like substances in cluster headache and common migraine. In : Clifford Rose F, ed. Progress in Migraine Research. London : Pittman 1984 : 199 204.
15. Jenkins DW, Langmead CJ, Parsons AA, Strijbos PJ. Regulation of calcitonin gene-related peptide release from rat trigeminal nucleus caudalis slices in vitro. Neurosci Lett. 2004 366 : 241 244.
16. Goadsby PJ, Edvinsson L. Human in vivo evidence for trigeminovascular activation in cluster headache. Neuropeptide changes and effects of acute attacks therapies. Brain. 1994 117 : 427 434.
17. Kruijver FP, Swaab DF. Sex hormone receptors are present in the human suprachiasmatic nucleus. Neuroendocrinology. 2002 75 : 296 305.
18. Kruijver FP, Balesar R, Espila AM, Unmehopa UA, Swaab DF. Estrogen receptor-alpha distribution in the human hypothalamus in relation to sex and endocrine status. J Comp Neurol. 2002 454 : 115 139.
19. Cohen O, Vinker S, Yaphe J, Kitai E. Hormone replacement therapy and WONCA/COOP functional status: A cross-sectional population-based study of women in Israel. Climacteric. 2005 8 : 171 176.