Chronic fenfluramine administration increases plasma serotonin (5-hydroxytryptamine) to nontoxic levels

Journal of Pharmacology and Experimental Therapeutics

Volumn 324, Issue 2, 2008, Pages 791-797

  Zolkowska, Dorota ^a   Baumann, Michael H ^a   Rothman, Richard B ^a  

^a NATIONAL INSTITUTE ON DRUG ABUSE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

5 HYDROXYINDOLEACETIC ACID; FENFLURAMINE; FLUOXETINE; NORADRENALIN; NORFENFLURAMINE; SEROTONIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN; CARDIOVASCULAR RISK; CONTROLLED STUDY; CORRELATION ANALYSIS; DIALYSATE; DRUG BLOOD LEVEL; DRUG EFFECT; ELECTROCHEMICAL DETECTION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IN VIVO STUDY; MALE; MICRODIALYSIS; NONHUMAN; PRIORITY JOURNAL; RAT; SEROTONIN BLOOD LEVEL; VALVULAR HEART DISEASE;

ANIMALS; DRUG ADMINISTRATION SCHEDULE; DRUG TOXICITY; FENFLURAMINE; MALE; RATS; RATS, SPRAGUE-DAWLEY; SEROTONIN; TIME FACTORS;

EID: 38749112529     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.107.132654     Document Type: Article

References (27)

1. Abenhaim L, Moride Y, Brenot F, Rich S, Benichou J, Kurz X, Higenbottam T, Oakley C, Wouters E, Aubier M, et al. (1996) Appetite-suppressant drugs and the risk of primary pulmonary hypertension. N Engl J Med 335:609-616.
2. Alvarez JC, Gluck N, Arnulf I, Quintin P, Leboyer M, Pecquery R, Launay JM, Perez-Diaz F, and Spreux-Varoquaux O (1999) Decreased platelet serotonin transporter sites and increased platelet inositol triphosphate levels in patients with unipolar depression: effects of clomipramine and fluoxetine. Clin Pharmacol Ther 66:617-624.
3. Artigas F, Sarrias MJ, Martinez E, Gelpi E, Alvarez E, and Udina C (1989) Increased plasma free serotonin but unchanged platelet serotonin in bipolar patients treated chronically with lithium. Psychopharmacology (Berl) 99:328-332.
4. Baumann MH, Ayestas MA, Dersch CM, Brockington A, Rice KC, and Rothman RB (2000) Effects of phentermine and fenfluramine on extracellular dopamine and serotonin in rat nucleus accumbens: therapeutic implications. Synapse 36:102-113.
5. Baumann MH, Ayestas MA, Dersch CM, and Rothman RB (2001) 1-(m-Chlorophenyl) piperazine (mCPP) dissociates in vivo serotonin release from long-term serotonin depletion in rat brain. Neuropsychopharmacology 24:492-501.
6. Celada P, Dolera M, Alvarez E, and Artigas F (1992) Effects of acute and chronic treatment with fluvoxamine on extracellular and platelet serotonin in the blood of major depressive patients: relationship to clinical improvement. J Affect Disord 25:243-249.
7. Connolly HM and McGoon MD (1999) Obesity drugs and the heart. Curr Probl Cardiol 24:745-792.
8. Eddahibi S, Guignabert C, Barlier-Mur AM, Dewachter L, Fadel E, Dartevelle P, Humbert M, Simonneau G, Hanoun N, Saurini F, et al. (2006) Cross talk between endothelial and smooth muscle cells in pulmonary hypertension: critical role for serotonin-induced smooth muscle hyperplasia. Circulation 113:1857-1864.
9. Eddahibi S, Raffestin B, Hamon M, and Adnot S (2002) Is the serotonin transporter involved in the pathogenesis of pulmonary hypertension? J Lab Clin Med 139:194-201.
10. Eddahibi S, Raffestin B, Launay JM, Sitbon M, and Adnot S (1998) Effect of dexfenfluramine treatment in rats exposed to acute and chronic hypoxia. Am J Respir Crit Care Med 157:1111-1119.
11. Fishman AP (1999) Aminorex to fen/phen: an epidemic foretold. Circulation 99:156-161.
12. Gustafsson BI, Tommeras K, Nordrum I, Loennechen JP, Brunsvik A, Solligard E, Fossmark R, Bakke I, Syversen U, and Waldum H (2005) Long-term serotonin administration induces heart valve disease in rats. Circulation 111:1517-1522.
13. Kema IP, de Vries EG, Schellings AM, Postmus PE, and Muskiet FA (1992) Improved diagnosis of carcinoid tumors by measurement of platelet serotonin. Clin Chem 38:534-540.
14. Kema IP, Meijer WG, Meiborg G, Ooms B, Willemse PH, and de Vries EG (2001) Profiling of tryptophan-related plasma indoles in patients with carcinoid tumors by automated, on-line, solid-phase extraction and HPLC with fluorescence detection. Clin Chem 47:1811-1820.
15. Launay JM, Herve P, Peoc'h K, Tournois C, Callebert J, Nebigil CG, Etienne N, Drouet L, Humbert M, Simonneau G, et al. (2002) Function of the serotonin 5-hydroxytryptamine 2B receptor in pulmonary hypertension. Nat Med 8:1129-1135.
16. Lundmark J, Reis M, and Bengtsson F (2001) Serum concentrations of fluoxetine in the clinical treatment setting. Ther Drug Monit 23:139-147.
17. MacLean MR, Herve P, Eddahibi S, and Adnot S (2000) 5-Hydroxytryptamine and the pulmonary circulation: receptors, transporters and relevance to pulmonary arterial hypertension. Br J Pharmacol 131:161-168.
18. Martín F and Artigas F. (1992) Simultaneous effects of p-chloroamphetamine, d-fenfluramine, and reserpine on free and stored 5-hydroxytryptamine in brain and blood. J Neurochem 59:1138-1144.
19. Meijer WG, Kema IP, Volmer M, Willemse PH, and de Vries EG (2000) Discriminating capacity of indole markers in the diagnosis of carcinoid tumors. Clin Chem 46:1588-1596.
20. Ni W and Watts SW (2006) 5-Hydroxytryptamine in the cardiovascular system: focus on the serotonin transporter (SERT). Clin Exp Pharmacol Physiol 33:575-583.
21. Robiolio PA, Rigolin VH, Wilson JS, Harrison JK, Sanders LL, Bashore TM, and Feldman JM (1995) Carcinoid heart disease. Correlation of high serotonin levels with valvular abnormalities detected by cardiac catheterization and echocardiography. Circulation 92:790-795.
22. Roth BL (2007) Drugs and valvular heart disease. N Engl J Med 356:6-9.
23. Rothman RB and Baumann M (2002) Therapeutic and adverse actions of serotonin transporter substrates. Pharmacol Ther 95:73-88.
24. 2B receptors in the cardiac valvulopathy associated with fenfluramine and other serotonergic medications. Circulation 102:2836-2841.
25. Rothman RB, Redmon JB, Raatz SK, Kwong CA, Swanson JE, and Bantle JP (2000b) Chronic treatment with phentermine combined with fenfluramine lowers plasma serotonin. Am J Cardiol 85:913-915.
26. Smith BM, Thomsen WJ, and Grottick AJ (2006) The potential use of selective 5-HT2C agonists in treating obesity. Expert Opin Investig Drugs 15:257-266.
27. Zolkowska D, Rothman RB, and Baumann MH (2006) Amphetamine analogs increase plasma serotonin: implications for cardiac and pulmonary disease. J Pharmacol Exp Ther 318:604-610.