Regulation of the adrenal androgen biosynthesis

Journal of Steroid Biochemistry and Molecular Biology

Volumn 108, Issue 3-5, 2008, Pages 281-286

  Rainey, William E ^a   Nakamura, Yasuhiro ^a  

^a MEDICAL COLLEGE OF GEORGIA   (United States)

Author keywords

3 Hydroxysteroid dehydrogenase; Adrenal; Androgen; Cytochrome b5; DHEA sulfotransferase

Indexed keywords

3(OR 17)BETA HYDROXYSTEROID DEHYDROGENASE; 3(OR 17)BETA HYDROXYSTEROID DEHYDROGENASE TYPE 2; ALDOSTERONE; ANDROGEN; CYTOCHROME B5; CYTOCHROME P450 17; HYDROCORTISONE; PRASTERONE; PRASTERONE SULFATE; STEROID 17,20 LYASE; STEROID SULFOTRANSFERASE; SULFOTRANSFERASE; UNCLASSIFIED DRUG;

ADRENAL GLAND; ADRENARCHE; ANDROGEN SYNTHESIS; ENZYME ACTIVITY; GENETIC TRANSCRIPTION; HORMONE SYNTHESIS; HUMAN; PROTEIN EXPRESSION; REVIEW; SEX DIFFERENCE; TRANSCRIPTION REGULATION; ZONA FASCICULATA; ZONA GLOMERULOSA;

ADRENAL GLANDS; ANDROGENS; CYTOCHROMES B5; DEHYDROEPIANDROSTERONE; DEHYDROEPIANDROSTERONE SULFATE; GATA6 TRANSCRIPTION FACTOR; HUMANS; PROGESTERONE REDUCTASE; RECEPTORS, ESTROGEN; STEROID 17-ALPHA-HYDROXYLASE; STEROIDOGENIC FACTOR 1; SULFOTRANSFERASES;

EID: 38749098098     PISSN: 09600760     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jsbmb.2007.09.015     Document Type: Review

References (41)

1. Yuen B.H., and Mincey E.K. Human chorionic gonadotropin, prolactin, estriol, and dehydroepiandrosterone sulfate concentrations in cord blood of premature and term newborn infants: relationship to the sex of the neonate. Am. J. Obstet. Gynecol. 156 2 (1987) 396-400
2. DePeretti E., and Forest M.G. Unconjugated dehydroepiandrosterone plasma levels in normal subjects from birth to adolescence in humans: the use of a sensitive radioimmunoassay. J. Clin. Endocrinol. Metab. 43 5 (1976) 982-991
3. Smith M.R., Rudd B.T., Shirley A., Rayner P.H., Williams J.W., Duignan N.M., and Bertrand P.V. A radioimmunoassay for the estimation of serum dehydroepiandrosterone sulphate in normal and pathological sera. Clin. Chim. Acta 65 1 (1975) 5-13
4. Ducharme J.R., Forest M.G., DePeretti E., Sempe M., Collu R., and Bertrand J. Plasma adrenal and gonadal sex steroids in human pubertal development. J. Clin. Endocrinol. Metab. 42 3 (1976) 468-476
5. Orentreich N., Brind J.L., Rizer R.L., and Vogelman J.H. Age changes and sex differences in serum dehydroepiandrosterone sulfate concentrations throughout adulthood. J. Clin. Endocrinol. Metab. 59 3 (1984) 551-555
6. Suzuki T., Sasano H., Takeyama J., Kaneko C., Freije W.A., Carr B.R., and Rainey W.E. Developmental changes in steroidogenic enzymes in human postnatal adrenal cortex: immunohistochemical studies. Clin. Endocrinol. (Oxf.) 53 6 (2000) 739-747
7. Bradshaw K.D., Waterman M.R., Couch R.T., Simpson E.R., and Zuber M.X. Characterization of complementary deoxyribonucleic acid for human adrenocortical 17 alpha-hydroxylase: a probe for analysis of 17 alpha-hydroxylase deficiency. Mol. Endocrinol. 1 5 (1987) 348-354
8. Kagimoto M., Winter J.S., Kagimoto K., Simpson E.R., and Waterman M.R. Structural characterization of normal and mutant human steroid 17 alpha-hydroxylase genes: molecular basis of one example of combined 17 alpha-hydroxylase/17,20-lyase deficiency. Mol. Endocrinol. 2 6 (1998) 564-570
9. Swart P., Estabrook R.W., Mason J.I., and Waterman M.R. Catalytic activity of human and bovine adrenal cytochromes P-450 17 alpha, lyase expressed in Cos 1 cells. Biochem. Soc. Trans. 17 6 (1989) 1025-1026
10. Yanase T., Sasano H., Yubisui T., Sakai Y., Takayanagi R., and Nawata H. Immunohistochemical study of cytochrome b5 in human adrenal gland and in adrenocortical adenomas from patients with Cushing's syndrome. Endocr. J. 45 1 (1998) 89-95
11. Auchus R.J., Lee T.C., and Miller W.L. Cytochrome b5 augments the 17,20-lyase activity of human P450c17 without direct electron transfer. J. Biol. Chem. 273 6 (1998) 3158-3165
12. Li X.R., Giordano S.J., Yoo M., and Steggles A.W. The isolation and characterization of the human cytochrome b5 gene. Biochem. Biophys. Res. Commun. 209 3 (1995) 894-900
13. Huang N., Dardis A., and Miller W.L. Regulation of cytochrome b5 gene transcription by Sp3, GATA-6, and steroidogenic factor 1 in human adrenal NCI-H295A cells. Mol. Endocrinol. 19 8 (2005) 2020-2034
14. Saner K.J., Suzuki T., Sasano H., Pizzey J., Ho C., Fstrauss III J., Carr B.R., and Rainey W.E. Steroid sulfotransferase 2A1 gene transcription is regulated by steroidogenic factor 1 and GATA-6 in the human adrenal. Mol. Endocrinol. 19 1 (2005) 184-197
15. Molkentin J.D. The zinc finger-containing transcription factors GATA-4, -5, and -6. Ubiquitously expressed regulators of tissue-specific gene expression. J. Biol. Chem. 275 50 (2000) 38949-38952
16. Charron F., Paradis P., Bronchain O., Nemer G., and Nemer M. Cooperative interaction between GATA-4 and GATA-6 regulates myocardial gene expression. Mol. Cell. Biol. 19 6 (1999) 4355-4365
17. Gao X., Sedgwick T., Shi Y.B., and Evans T. Distinct functions are implicated for the GATA-4, -5, and -6 transcription factors in the regulation of intestine epithelial cell differentiation. Mol. Cell. Biol. 18 5 (1998) 2901-2911
18. Heikinheimo M., Ermolaeva M., Bielinska M., Rahman N.A., Narita N., Huhtaniemi I.T., Tapanainen J.S., and Wilson D.B. Expression and hormonal regulation of transcription factors GATA-4 and GATA-6 in the mouse ovary. Endocrinology 138 8 (1997) 3505-3514
19. Ketola I., Pentikainen V., Vaskivuo T., Ilvesmaki V., Herva R., Dunkel L., Tapanainen J.S., Toppari J., and Heikinheimo M. Expression of transcription factor GATA-4 during human testicular development and disease. J. Clin. Endocrinol. Metab. 85 10 (2000) 3925-3931
20. Kiiveri S., Liu J., Westerholm-Ormio M., Narita N., Wilson D.B., Voutilainen R., and Heikinheimo M. Differential expression of GATA-4 and GATA-6 in fetal and adult mouse and human adrenal tissue. Endocrinology 143 8 (2002) 3136-3143
21. Jimenez P., Saner K., Mayhew B., and Rainey W.E. GATA-6 is expressed in the human adrenal and regulates transcription of genes required for adrenal androgen biosynthesis. Endocrinology 144 10 (2003) 4285-4286
22. Seely J., Amigh K.S., Suzuki T., Mayhew B., Sasano H., Giguere V., Laganiere J., Carr B.R., and Rainey W.E. Transcriptional regulation of dehydroepiandrosterone sulfotransferase (SULT2A1) by estrogen-related receptor alpha. Endocrinology 146 8 (2005) 3605-3613
23. Simard J., de Launoit Y., and Labrie F. Characterization of the structure-activity relationships of rat types I and II 3 beta-hydroxysteroid dehydrogenase/delta 5-delta 4 isomerase by site-directed mutagenesis and expression in HeLa cells. J. Biol. Chem. 266 23 (1991) 14842-14845
24. Conley A.J., and Bird I.M. The role of cytochrome P450 17 alpha-hydroxylase and 3 beta-hydroxysteroid dehydrogenase in the integration of gonadal and adrenal steroidogenesis via the delta 5 and delta 4 pathways of steroidogenesis in mammals. Biol. Reprod. 56 4 (1997) 789-799
25. Wang W., Yang L., Suwa T., Casson P.R., and Hornsby P.J. Differentially expressed genes in zona reticularis cells of the human adrenal cortex. Mol. Cell. Endocrinol. 173 1-2 (2001) 127-134
26. Rainey W.E., Carr B.R., Wang Z.N., and Parker Jr. C.R. Gene profiling of human fetal and adult adrenals. J. Endocrinol. 171 2 (2001) 209-215
27. Doody K.M., Carr B.R., Rainey W.E., Byrd W., Murry B.A., Strickler R.C., Thomas J.L., and Mason J.I. 3 beta-hydroxysteroid dehydrogenase/isomerase in the fetal zone and neocortex of the human fetal adrenal gland. Endocrinology 126 5 (1990) 2487-2492
28. Parker Jr. C.R., Faye-Petersen O., Stankovic A.K., Mason J.I., and Grizzle W.E. Immunohistochemical evaluation of the cellular localization and ontogeny of 3 beta-hydroxysteroid dehydrogenase/delta 5-4 isomerase in the human fetal adrenal gland. Endocr. Res. 21 1-2 (1995) 69-80
29. Narasaka T., Suzuki T., Moriya T., and Sasano H. Temporal and spatial distribution of corticosteroidogenic enzymes immunoreactivity in developing human adrenal. Mol. Cell. Endocrinol. 174 1-2 (2001) 111-120
30. Endoh A., Kristiansen S.B., Casson P.R., Buster J.E., and Hornsby P.J. The zona reticularis is the site of biosynthesis of dehydroepiandrosterone and dehydroepiandrosterone sulfate in the adult human adrenal cortex resulting from its low expression of 3 beta-hydroxysteroid dehydrogenase. J. Clin. Endocrinol. Metab. 81 10 (1996) 3558-3565
31. Nuclear Receptors Nomenclature Committee. A unified nomenclature system for the nuclear receptor superfamily. Cell 97 2 (1999) 161-163
32. Giguere V. Orphan nuclear receptors: from gene to function. Endocr. Rev. 20 5 (1999) 689-725
33. Murphy E.P., and Conneely O.M. Neuroendocrine regulation of the hypothalamic pituitary adrenal axis by the nurr1/nur77 subfamily of nuclear receptors. Mol. Endocrinol. 11 1 (1997) 39-47
34. Wilson T.E., Mouw A.R., Weaver C.A., Milbrandt J., and Parker K.L. The orphan nuclear receptor NGFI-B regulates expression of the gene encoding steroid 21-hydroxylase. Mol. Cell. Biol. 13 2 (1993) 861-868
35. Chang S.F., and Chung B.C. Difference in transcriptional activity of two homologous CYP21A genes. Mol. Endocrinol. 9 10 (1995) 1330-1336
36. Bassett M.H., Suzuki T., Sasano H., White P.C., and Rainey W.E. The orphan nuclear receptors NURR1 and NGFIB regulate adrenal aldosterone production. Mol. Endocrinol. 18 2 (2004) 279-290
37. Bassett M.H., Suzuki T., Sasano H., De Vries C.J., Jimenez P.T., Carr B.R., and Rainey W.E. The orphan nuclear receptor NGFIB regulates transcription of 3beta-hydroxysteroid dehydrogenase. Implications for the control of adrenal functional zonation. J. Biol. Chem. 279 36 (2004) 37622-37630
38. Goto M., Piper H.K., Marcos J., Wood P.J., Wright S., Postle A.D., Cameron I.T., Mason J.I., Wilson D.I., and Hanley N.A. In humans, early cortisol biosynthesis provides a mechanism to safeguard female sexual development. J. Clin. Invest. 116 4 (2006) 953-960
39. Leers-Sucheta S., Morohashi K., Mason J.I., and Melner M.H. Synergistic activation of the human type II 3β-hydroxysteroid dehydrogenase/delta 5-delta 4 isomerase promoter by the transcription factor steroidogenic factor-1/adrenal 4-binding protein and phorbol ester. J. Biol. Chem. 272 12 (1997) 7960-7967
40. Martin L.J., Taniguchi H., Robert N.M., Simard J., Tremblay J.J., and Viger R.S. GATA factors and the nuclear receptors, steroidogenic factor 1/liver receptor homolog 1, are key mutual partners in the regulation of the human 3beta-hydroxysteroid dehydrogenase type 2 promoter. Mol. Endocrinol. 19 9 (2005) 2358-2370
41. Rainey W.E., Carr B.R., Sasano H., Suzuki T., and Mason J.I. Dissecting human adrenal androgen production. Trends Endocrinol. Metab. 13 6 (2002) 234-239