A rapid and highly sensitive method for the determination of glimepiride in human plasma by liquid chromatography-electrospray ionization tandem mass spectrometry: Application to a pre-clinical pharmacokinetic study

Biomedical Chromatography

Volumn 22, Issue 1, 2008, Pages 58-63

  Chakradhar, Lagishetty ^a   Kallem, Rajareddy ^a   Karthik, Arumugam ^a   Tripura Sundari, Bala ^a   Ramesh, Srirangam ^a   Mullangi, Ramesh ^a   Srinivas, Nuggehally R ^a  

^a DR REDDY'S LABORATORIES LTD   (India)

Author keywords

Glibenclamide; Glimepiride; Human plasma; LC MS MS; Method validation; Pharmacokinetics; Rats

Indexed keywords

ELECTROSPRAY IONIZATION; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; PLASMA (HUMAN); SOLVENT EXTRACTION;

ELECTROSPRAY IONIZATION TANDEM MASS SPECTROMETRY; GLIBENCLAMIDE; GLIMEPIRIDE; HUMAN PLASMAS; LC-MS-MS; LC.MS/MS; LIQUID CHROMATOGRAPHY ELECTROSPRAY; METHOD VALIDATIONS; PRE-CLINICAL; SENSITIVE METHOD;

PHARMACOKINETICS;

ACETIC ACID ETHYL ESTER; ACETONITRILE; AMMONIUM ACETATE; GLIBENCLAMIDE; GLIMEPIRIDE; METHANOL;

ACCURACY; ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; CORRELATION COEFFICIENT; DRUG BLOOD LEVEL; DRUG DETERMINATION; DRUG ELIMINATION; DRUG HALF LIFE; DRUG ISOLATION; ELECTROSPRAY MASS SPECTROMETRY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; LIQUID LIQUID EXTRACTION; MALE; MAXIMUM PLASMA CONCENTRATION; NONHUMAN; PROCESS DEVELOPMENT; QUANTITATIVE ANALYSIS; RAT; RELIABILITY; SENSITIVITY ANALYSIS; SENSITIVITY AND SPECIFICITY; SOLVENT EXTRACTION; TANDEM MASS SPECTROMETRY; TIME TO MAXIMUM PLASMA CONCENTRATION; VALIDATION PROCESS;

RATTUS;

EID: 38749093672     PISSN: 02693879     EISSN: 10990801     Source Type: Journal    
DOI: 10.1002/bmc.896     Document Type: Article

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