A novel salted-out and subsequently crosslinked poly(lactic-co-glycolic acid) polymeric scaffold applied to monolithic drug delivery

Journal of Bioactive and Compatible Polymers

Volumn 23, Issue 2, 2008, Pages 132-153

  Sibambo, Sibongile R ^a   Pillay, Viness ^a   Choonara, Yahya E ^a   Penny, Clement ^a  

^a UNIVERSITY OF THE WITWATERSRAND   (South Africa)

Author keywords

(PLGA)3 Box Behnken design; Controlled drug release; Crosslinking; Physicochemical; Physicomechanical; Poly(lactic co glycolic) acid; Salting out; Textural profiling.

Indexed keywords

CORRELATION METHODS; CROSSLINKING; ENERGY ABSORPTION; RANDOM PROCESSES; ULTRAVIOLET SPECTROSCOPY;

MATRIX RESILIENCE; MELATONIN; STRUCTURAL THERMAL ANALYSIS; TEXTURE PROFILE ANALYSIS;

DRUG DELIVERY;

ALUMINUM CHLORIDE; ELECTROLYTE; MELATONIN; PHOSPHATE BUFFERED SALINE; POLYGLACTIN; SODIUM CHLORIDE;

ARTICLE; CONTROLLED DRUG RELEASE; CORRELATION ANALYSIS; CROSS LINKING; DRUG DELIVERY SYSTEM; IN VITRO STUDY; PHYSICAL CHEMISTRY; STATISTICAL SIGNIFICANCE; ULTRAVIOLET SPECTROSCOPY;

EID: 38749086859     PISSN: 08839115     EISSN: 15308030     Source Type: Journal    
DOI: 10.1177/0883911507088274     Document Type: Article

References (27)

1. Dashevsky, A., Wagner, K., Kolter, K. and Bodmeier, R. (2005). Physicochemical and Release Properties of Pellets Coated with kollicoat SR 30D, A New Aqueous Polyvinyl Acetate Dispersion for Extended Release, Int. J. Pharm., 290 (1-2). 15 - 23.
2. Dayal, P., Pillay, V., Babu, R.J. and Singh, M. (2005). Box-Behnken Experimental Design in the Development of a Nasal Drug Delivery System of Model Drug Hydroxyurea: Characterization of Viscosity, In Vitro Drug Release, Droplet Size, and Dynamic Surface Tension, AAPS Pharm. Sci. Tech., 6 (4). E573 - 85.
3. Huang, S.F., Chen, J.L., Yeh, M.K. and Chiang, C.H. (2005). Physicochemical Properties and In Vivo Assessment of Timolol-Loaded Poly(D,L-lactide-co-glycolide) Films for Long-term Intraocular Pressure Lowering Effects, Ocular. Pharmacol. Ther., 21 (6). 445 - 53.
4. Jones, D.S., Andrew, G.P. and Gorman, S.P. (2005). Characterization of Cross-Linking Effects on the Physicochemical and Drug Diffusional Properties of Cationic Hydrogels Designed as Bioactive Urological Biomaterials, J. Pharm. Pharmacol., 57 (10). 1251 - 59.
5. Young, C.R., Dietzsch, C., Cerea, M., Farrell, T., Fegely, K.A., Rajabi-Siahboomi, A. and McGinity, J.W. (2005). Physicochemical Characterization and Mechanisms of Release of Theophylline from Melt-Extruded Dosage Forms Based on a Methacrylic Acid Copolymer, Int. J. Pharm., 301 (1-2). 112 - 20.
6. Avgoustakis, K. (2004). Pegylated poly(lactide) and Poly(lactide-co- glycolide) Nanoparticles: Preparation, Properties and Possible Applications in Drug Delivery, Curr. Drug Deliv., 1 (4). 321 - 33.
7. Izutsu, K. and Aoyagi, N. (2005). Effect of Inorganic Salts on Crystallization of Poly(ethylene glycol) in Frozen Solutions, Int. J. Pharm., 288 (1). 101 - 8.
8. Gao, Q., Xue, S., Doneanu, C.E., Shaffer, S.A., Goodlett, D.R. and Nelson, S.D. (2006). Pro-crosslink. Software Tool for Protein Cross-Linking and Mass Spectrometry, Anal. Chem., 78 (7). 2145 - 9.
9. Horvath, A.L. (1985). Handbook of Aqueous Electrolyte Solutions, John Wiley and Sons, New York.
10. Tanaka, M. and Takahashi, K. (2000). Determination of the Changes of the Basic Structures of Silics Species in Dependence on the Concentration of Sodium Chloride by FAB-MS, Fresenius. J. Anal. Chem., 368 (8). 786 - 90.
11. Pillay, V. and Fassihi, R. (1999). Electrolyte-induced Compositional Heterogeneity: A Novel Approach for Rate-Controlled Oral Drug Delivery, J. Pharm. Sci., 88 (11). 1140 - 8.
12. Pillay, V. and Fassihi, R. (2001). Probing the Dynamics of Matrix in the Presence of Electrolytes, Drug Deliv., 8 (2). 87 - 92.
13. Sibambo, S.R., Pillay, V., Choonara, Y.E., Khan, R.A. and Sweet, J.L. (2007). Elucidation of the Physico-mechanical and Ab Initio Quantum Energy Transitions of a Crosslinked PLGA Scaffold, Biomaterials, 28: 3714 - 23.
14. Swenson, J., Smalley, M.V., Hatharasinghe, H.L.M. and Fragneto, G. (2001). Interlayer Structure of a Clay-polymer-salt-water System, Langmuir, 17: 3813 - 18.
15. Melander, W. and Horvath, C. (1977). Salt Effect on Hydrophobic Interactions in Precipitation and Chromatography of Proteins: An Interpretation of the Lyotropic Series, Arch. Biochem. Biophys., 183 (1). 200 - 15.
16. Arakawa, T. and Timasheff, S.N. (1985). Mechanism of Poly(ethylene glycol) Interaction with Proteins, Biochemistry, 24: 6756 - 62.
17. Galinski, E.A., Stein, M., Amendt, B., Kinder, M. (1997). The Kosmotropic (structure-forming) Effect of Compensatory Solutes, Comp. Biochem. Physiol., 117A: 357 - 65.
18. Moelbert, S., Normand, B. and DeLos Rios, P. (2004). Kosmotropes and Chaotropes: Modelling Preferential Exclusion, Binding and Aggregate Stability, Biophysical Chemistry, 112: 45 - 57.
19. Bolen, D.W. and Baskakov, I.V. (2001). The Osmophobic Effect: Natural Selection of a Thermodynamic Force in Protein Folding, J. Mol. Biol., 310: 955 - 63.
20. Langer, R.S. and Peppas, N.A. (1981). Present and Future Applications of Biomaterials in Controlled Drug Delivery Systems, Biomaterials, 2 (4). 201 - 14.
21. Nyström, B., Thuresson, K. and Lindmad, B. (1995). Rheological and Dynamic Light-Scattering Studies on Aqueous Solutions of a Hydrophobically Modified Nonionic Cellulose Ether and Its Unmodified Analogue, Langmuir, 11: 1994 - 2002.
22. DeLuca, P., Mehta, R.C., Hausberger, A.G. and Thanoo, B.C. (1993). Biodegradable Polyesters for Drug and Polypeptide Delivery. In: El-Nokaly, M.A., Piatt, D.M. and Charpentier, B.A. (eds), Polymeric Drug Delivery Systems, Washington, DC. American Chemical Society.
23. Mehta, R.C., Jeyanthi, R., Calis, S., Thanoo, B.C., Burton, K.W. and DeLuca, P.P. (1994). Biodegradable Microspheres as a Depot System for Parenteral Delivery of Peptide Drugs, J. Control. Rel., 29: 375 - 84.
24. Shive, M.S. and Anderson, J.M. (1997). Biodegradation and Biocompatibility of PLA and PLGA Microspheres, Adv Drug Deliv Rev., 28 (1). 5 - 24.
25. Kelly, A. (1987). An Outline of Trends in Materials Science and Processing, Mat. Sci. Eng., 85: 1 - 13.
26. Paulaitis, M.E. and Rpratt, L. (2002). Hydration Theory for Molecular Biophysics, Adv. Protein Chem., 62: 283 - 310.
27. Bernazzani, L., Gianni, P., Mollica, V. and Pizzolla, P. (2004). Group Contributions to Enthalpies of Solvation in Octan-1-ol and Di-n-butyl Ether, Thermochimica Acta, 418 (1-2). 109 - 16.