Polylactide microspheres prepared by premix membrane emulsification-Effects of solvent removal rate

Journal of Membrane Science

Volumn 310, Issue 1-2, 2008, Pages 484-493

  Sawalha, Hassan ^a   Purwanti, Nanik ^a   Rinzema, Arjen ^a   Schroën, Karin ^a   Boom, Remko ^a  

^a WAGENINGEN UNIVERSITY   (Netherlands)

Author keywords

Morphology; Nonsolvent; Polylactide microspheres; Pre mix membrane emulsification; Size distribution; Solvent removal; Ultrasound contrast agents

Indexed keywords

CONCENTRATION (PROCESS); DICHLOROMETHANE; EXTRACTION; MASS TRANSFER; MICROSPHERES; PARTICLE SIZE; PHASE EQUILIBRIA; SOLVENTS;

POLYLACTIDE MICROSPHERES; SOLVENT REMOVAL; ULTRASOUND CONTRAST AGENTS;

EMULSIFICATION;

DICHLOROMETHANE; METHANOL; POLYLACTIDE; SOLVENT; WATER;

CONCENTRATION (PROCESS); DICHLOROMETHANE; EMULSIFICATION; EXTRACTION; MASS TRANSFER; MICROSPHERES; PARTICLE SIZE; PHASE EQUILIBRIA; SOLVENTS;

ARTICLE; ARTIFICIAL MEMBRANE; COMPUTER SIMULATION; EMULSION; GLASS MEMBRANE; POROSITY; PRIORITY JOURNAL; SOLUBILITY; SOLVENT EXTRACTION;

EID: 38649139102     PISSN: 03767388     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.memsci.2007.11.029     Document Type: Article

References (25)

1. Ravi Kumar M.N. Nano and microparticles as controlled drug delivery devices. J. Pharm. Pharm. Sci. 3 (2000) 234
2. Dayton P.A., Chomas J.E., Lum A.F.H., Allen J.S., Lindner J.R., Simon S.I., and Ferrara K.W. Optical and acoustical dynamics of microbubble contrast agents inside neutrophils. Biophys. J. 80 (2001) 1547
3. Schutt E.G., Klein D.H., Mattrey R.M., and Riess J.G. Injectable microbubbles as contrast agents for diagnostic ultrasound imaging: the key role of perfluorochemicals. Angew. Chem. Int. Ed. 42 (2003) 3218
4. Bloch S.H., Short R.E., Ferrara K.W., and Wisner E.R. The effect of size on the acoustic response of polymer-shelled contrast agents. Ultrasound Med. Biol. 31 (2005) 439
5. De Jong N., Bouakaz A., and Frinking P. Basic acoustic properties of microbubbles. Echocardiography 19 (2002) 229
6. ®. Ultrasound Med. Biol. 22 (1996) 441
7. Feinstein S.B., Keller M.W., Kerber R.E., Vandenberg B., Hoyte J., Kutruff C., Bingle J., and Welsh A.H. Sonicated echocardiographic contrast agents: reproducibility studies. J. Am. Soc. Echocardiogr. 2 (1989) 125
8. Winkelmann J.W., Kenner M.D., Dave R., Chandwaney R.H., and Feinstein S.B. Contrast echocardiography. Ultrasound Med. Biol. 20 (1994) 507
9. Ma G., Nagai M., and Omi S. Preparation of uniform poly(lactide) microspheres by employing the Shirasu Porous Glass (SPG) emulsification technique. Colloids Surf. A 153 (1999) 383
10. Ma G.-H., Omi S., Dimonie V.L., Sudol E.D., and El-Aasser M.S. Study of the preparation and mechanism of formation of hollow monodisperse polystyrene microspheres by SPG (Shirasu Porous Glass) emulsification technique. J. Appl. Polym. Sci. 85 (2002) 1530
11. Vladisavljević G.T., and Williams R.A. Recent developments in manufacturing emulsions and particulate products using membranes. Adv. Colloid Interface Sci. 113 (2005) 1
12. Liu R., Ma G., Meng F.-T., and Su Z.-G. Preparation of uniform-sized PLA microcapsules by combining Shirasu Porous Glass membrane emulsification technique and multiple emulsion-solvent evaporation method. J. Control. Rel. 103 (2005) 31
13. van de Witte P., Dijkstra P.J., van den Berg J.W.A., and Feijen J. Phase separation processes in polymer solutions in relation to membrane formation. J. Membr. Sci. 117 (1996) 1
14. Sawalha H., Schroën K., and Boom R. Polylactide films formed by immersion precipitation: effects of additives, nonsolvent, and temperature. J. Appl. Polym. Sci. 104 (2007) 959
15. Sawalha H., Schroën K., and Boom R. Mechanical properties and porosity of polylactide for biomedical applications. J. Appl. Polym. Sci. 107 (2007) 82
16. Perry R.H., and Green D.W. Perry's Chemical Engineers' Handbook (1997), McGraw-Hill, New York, USA pp. 5-65
17. Taylor R., and Khrisna R. Multicomponent Mass Transfer (1993), John Wiley & Sons, Inc., New York
18. Wesselingh J.A., and Khrisna R. Mass Transfer in Multicomponent Mixtures (2000), Delft University Press, Delft
19. Hartmans S., and Tramper J. Dichloromethane removal from waste gases with a trickle-bed bioreactor. Bioprocess. Eng. 6 (1991) 83
20. Lee Y.E., and Li S.F.Y. Binary diffusion coefficients of the methanol/water system in the temperature range 30-40 °C. J. Chem. Eng. Data 36 (1991) 240
21. Reid R.C., Prausnitz J.M., and Poling B.E. The Properties of Gases and Liquids (1987), McGraw-Hill, Inc., New York
22. Winkle V.M. Distillation (1967), McGraw-Hill, Inc., New York
23. Peschke N., and Sandler S.I. Liquid-liquid equilibria of fuel oxygenate + water + hydrocarbon mixtures. 1. J. Chem. Eng. Data 40 (1995) 315
24. Vladisavljević G.T., Shimizu M., and Nakashima T. Production of multiple emulsions for drug delivery systems by repeated SPG membrane homogenization: influence of mean pore size, interfacial tension and continuous phase viscosity. J. Membr. Sci. 284 (2006) 373
25. Van Der Graaf S., Steegmans M.L.J., Van Der Sman R.G.M., Schroën C.G.P.H., and Boom R.M. Droplet formation in a T-shaped microchannel junction: a model system for membrane emulsification. Colloids Surf. A 266 (2005) 106