Therapeutic potentials of combined use of DMSA with calcium and ascorbic acid in the treatment of mild to moderately lead intoxicated mice

BioMetals

Volumn 21, Issue 1, 2008, Pages 1-8

  Liao, Yingjun ^a   Zhang, Jun ^b   Jin, Yaping ^a   Lu, Chunwei ^a   Li, Gexin ^a   Yu, Fei ^a   Zhi, Xuping ^a   An, Li ^a   Yang, Jun ^a  

^a CHINA MEDICAL UNIVERSITY   (China)

^b LIAONING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE   (China)

Author keywords

Aminolevulinic acid dehydratase (ALAD); Ascorbic acid; Calcium; Lead body burden; Lead intoxicated mice; Meso 2,3 dimercaptosuccinic acid (DMSA)

Indexed keywords

ASCORBIC ACID; CALCIUM CARBONATE; LEAD; SUCCIMER;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ATOMIC ABSORPTION SPECTROMETRY; COMBINATION CHEMOTHERAPY; CONTROLLED STUDY; DRUG EFFECT; DRUG EFFICACY; FEMALE; LEAD BLOOD LEVEL; LEAD POISONING; MONOTHERAPY; MOUSE; NONHUMAN; TREATMENT OUTCOME;

ANIMALS; ASCORBIC ACID; CALCIUM; DRUG THERAPY, COMBINATION; FEMALE; LEAD; LEAD POISONING; MICE; PORPHOBILINOGEN SYNTHASE; SEVERITY OF ILLNESS INDEX; SUCCIMER; VITAMINS;

MUS;

EID: 38649133346     PISSN: 09660844     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10534-007-9086-7     Document Type: Article

References (35)

1. American Academy of Pediatrics (1995) Committee on drugs. Treatment guidelines for lead exposure in children. Pediatrics 96:155-60
2. Berlin A, Schaller KH (1974) European Standardized Method for the determination of aminolevulinic acid dehydratase activity in blood. Zeitsch Klin Chem Klin Biochem 12:389-90
3. Canfield RL, Henderson CR, Cory-Slechta DA, Cox C, Jusko TA, Lanphear BP (2003) Intellectual impairment in children with blood lead concentrations below 10 μg per deciliter. N Engl J Med 348:1517-26
4. Chen A, Dietrich KN, Ware JH, Radcliffe J, Rogan WJ (2005) IQ and Blood Lead from 2 to 7 Years of Age: Are the Effects in Older Children the Residual of High Blood Lead Concentrations in 2-Year-Olds? Environ Health Perspect 113:597-601
5. Cremin JD, Luck ML, Laughlin NK et al (2001). Oral succimer decreases the gastrointestinal absorption of lead in juvenile monkeys. Environ Health Perspect 109:613-9
6. Dalley JW, Gupta PK, Hung CT (1990) A physiological pharmacokinetic model describing the disposition of lead in the absence and presence of L-ascorbic acid in rats. Toxicol Lett 50:337-48
7. Dawson EB, Evans DR, Harris WA et al (1999) The effect of ascorbic acid supplement on the blood lead levels of smokers. J Am Coll Nutr 18:166-70
8. Dietrich KN, Ware JH, Salganik M, Radcliffe J, Rogan WJ, Rhoads GG et al (2004) Effect of chelation therapy on the neuropsychological and behavioral development of lead-exposed children after school entry. Pediatrics 114:19-26
9. Flora SJS, Pande M, Mehta A (2003) Beneficial effect of combined administration of some naturally occurring antioxidants (vitamins) and thiol chelators in the treatment of chronic lead intoxication. Chem Biol Interact 145:267-80
10. Fullmer CS (1991) Intestinal calcium and lead absorption: effects of dietary lead and calcium. Environ Res 54:159-69
11. Gurer H, Ercal N (2000) Can antioxidants be beneficial in the treatment of lead poisoning? Free Radical Biology And Medicine 29:927-945
12. Han S, Pfizenmaier DH, Garcia E (2000) Effects of lead exposure before pregnancy and dietary calcium during pregnancy on fetal development and lead accumulation. Environ Health Perspect 108:527-31
13. Houston DK, Johnson MA (2000) Does Vitamin C intake protect against lead toxicity? Nutr Rev 58:73-5
14. Hsu PC, Guo YL (2002) Antioxidant nutrients and lead toxicity. Toxicology 180:33-44
15. Jin YP, Kobayashi EK, Nogawa KJ et al. (2000) Determination of Urinary Lead Levels in Normal Population by Graphite-furnace Atomic Absorption Spectrophotometry Using Palladium Chloride as the Matrix Modifier. Analytical Letters 33:1409-24
16. Kalia K, Flora SJ (2005) Strategies for safe and effective therapeutic measures for chronic arsenic and lead poisoning. J Occup Health 47:1-21
17. Kalra V, Dua T, Kumar V, Kaul B (2002) Succimer in Symptomatic Lead Poisoning. Indian Pediatrics 39:580-5
18. Lidsky TI, Schneider JS (2003) Lead neurotoxicity in children: basic mechanisms and clinical correlates. Brain 126:5-19
19. Liebelt EL, Shannon M, Graef JW (1994) Efficacy of oral meso-2,3-dimercaptosuccinic acid therapy for low level childhood plumbism. J Pediatr 124:313-7
20. Kleszczewska E (2001) Biological role of reactions of L-ascorbic acid with metals. Postepy Hig Med Dosw 55:81-94
21. Markowitz ME, Sinnett M, Rosen JF (2004) A randomized trial of calcium supplement for childhood lead poisoning. Pediatrics 113:34-9
22. Miller AL (1998) Dimercaptosuccinic acid (DMSA), a non-toxic, water-soluble treatment for heavy metal toxicity. Altern Med Rev 3:199-207
23. Nightangle SL (1991) Succimer (DMSA) approved for severe lead poisoning. JAMA 265:1802
24. Patra RC, Swarup D, Dwivedi SK (2001) Antioxidant effects of α-tocopherol, ascorbic acid and L-methionine on lead induced oxidative stress to the liver kidney and brain in rats. Toxicology 162:81-8
25. Peterson KE, Salganik M, Campbell C, Rhoads GG, Rubin J, Berger O et al (2004) Effect of Succimer on Growth of Preschool Children with Moderate Blood Lead Levels. Environmental Health Perspectives 112:233-7
26. Pounds JG, Long GJ, Rosen JF (1991) Cellular and molecular toxicity of lead in bone. Environ Health Perspect 91:17-32
27. Shalana MG, Mostafab MS, Hassounab MM, Hassab El-Nabic SE, El-Refaied A (2005) Amelioration of lead toxicity on rat liver with Vitamin C and silymarin supplements. Toxicology 206:1-15
28. Silbergeld EK, Shwartz J, Mahaffey KR (1988) Lead and osteoporosis: mobilization of lead from bone in postmenopausal women. Environ Res 47:79-94
29. Simon JA, Hudes ES (1999) Relationship of ascorbic acid to blood lead levels. JAMA 281:2289-93
30. Smith DR, Calacsan C, Woolard D (2000) Succimer and the urinary excretion of essential elements in a primate model of childhood lead exposure. Toxicol Sci 54:473-80
31. Stangle DE, Strawderman MS, Smith D, Kuypers M, Strupp BJ (2004) Reductions in blood lead overestimate reductions in brain lead after repeated succimer regimens in a rodent model of childhood lead exposure. Environ Health Perspect 112:302-8
32. Upasani CD, Khera A, Balaraman R (2001) Effect of lead with Vitamins E, C, or Spirulina on malondialdehyde: conjugated dienes and hydroperoxides in rats. Indian J Exp Biol 39:70-4
33. Varnai VM, Piasek M, Blanusa M, Juresa D, Saric M, Kostial K (2003) Ascorbic acid supplementation does not improve efficacy of meso- dimercaptosuccinic acid treatment in treatment of lead-exposed suckling rats. Pharmacol Toxicol 93:180-5
34. Varnai VM, Piasek M, Blanusa M (2004) Succimer treatment and calcium supplementation reduce tissue lead in suckling rats. J Appl Toxicol 24:123-8
35. Wang S, Zhang J (2006) Blood lead levels in children, China. Environ Res 101:412-8