The control of hepatic glycogen metabolism in an in vitro model of sepsis

Molecular and Cellular Biochemistry

Volumn 308, Issue 1-2, 2008, Pages 183-192

  Wallington, Jennifer ^a   Ning, Jian ^a   Titheradge, Michael Alan ^a  

^a UNIVERSITY OF SUSSEX   (United Kingdom)

Author keywords

Endotoxic; Glycogen; Interferon ; Interleukin 1 ; Lipopolysaccharide; Liver; Tumour necrosis factor

Indexed keywords

BACTERIUM LIPOPOLYSACCHARIDE; CYTOKINE; GLUCOKINASE; GLUCOSE 6 PHOSPHATASE; GLUCOSE 6 PHOSPHATE; GLYCOGEN; GLYCOGEN PHOSPHORYLASE; GLYCOGEN SYNTHASE; HEXOKINASE; LACTIC ACID; N(G) METHYLARGININE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; PHOSPHORYLASE; PYRUVIC ACID; URIDINE DIPHOSPHATE GLUCOSE;

ANIMAL CELL; ARTICLE; CARBOHYDRATE TRANSPORT; CELL CULTURE; CONTROLLED STUDY; CORRELATION ANALYSIS; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; GLYCOGEN LIVER LEVEL; GLYCOGEN METABOLISM; GLYCOGEN SYNTHESIS; HORMONAL REGULATION; IN VITRO STUDY; MALE; METABOLIC REGULATION; NONHUMAN; RAT; SEPSIS;

ADENYLATE KINASE; ANIMALS; CYTOKINES; DISEASE MODELS, ANIMAL; GLUCOSE; GLUCOSE-6-PHOSPHATE; GLYCOGEN PHOSPHORYLASE; GLYCOGEN SYNTHASE; GLYCOGEN SYNTHASE KINASE 3; GLYCOGENOLYSIS; HUMANS; LACTIC ACID; LIPOPOLYSACCHARIDES; LIVER; LIVER GLYCOGEN; MALE; OMEGA-N-METHYLARGININE; PHOSPHORYLATION; PROTEIN KINASES; PYRUVIC ACID; RATS; RATS, SPRAGUE-DAWLEY; SEPSIS; URIDINE DIPHOSPHATE GLUCOSE;

EID: 38649118820     PISSN: 03008177     EISSN: 15734919     Source Type: Journal    
DOI: 10.1007/s11010-007-9627-y     Document Type: Article

References (61)

1. Kilbourn R (1997) Nitric oxide and shock. Dis Mon 43:281-348
2. Titheradge MA (1999) Nitric oxide in septic shock. Biochim Biophys Acta 1411:437-455
3. Williamson JR, Refino C, LaNoue K (1970) Effects of E. coli lipopolysaccharide B treatment of rats on gluconeogenesis. In: Porter T, Knight J (eds) CIBA foundation symposium on energy metabolism in trauma. Churchill, London, pp. 145-154
4. Wolfe RR, Burke JF (1978) Glucose and lactate metabolism in experimental septic shock. Am J Physiol 4:R219-R227
5. Knowles RG, Beevers SJ, Pogson CI (1986) The roles of glucagon, insulin and glucocorticoid hormones in the effects of sublethal doses of endotoxin on glucose hoeostasis in rats. Biochem Pharmacol 35:4043-4048
6. Knowles RG, McCabe JP, Beevers SJ et al (1987) The characteristics and site of inhibition of gluconeogenesis in rat liver cells by bacterial endotoxin. Biochem J 242:721-728
7. Ceppi ED, Knowles RG, Carpenter KM, Titheradge MA (1992) Effect of treatment in vivo of rats with bacterial endotoxin on fructose 2,6-bisphosphate metabolism and L-pyruvate kinase activity and flux in isolated liver cells. Biochem J 284:761-766
8. Liu MS, Kang GF (1987) Liver glycogen metabolism in endotoxin shock. 1. Endotoxin administration decreases glycogen synthase activities in dog livers. Biochem Med Metab Biol 37:61-72
9. Casteleijn E, Kuiper J, Van Rooij HC et al (1988) Endotoxin stimulates glycogenolysis in the liver by means of intercellular communication. J Biol Chem 263:6953-6955
10. Bagby GJ, Lang CH, Hargrove DM et al (1988) Glucose kinetics in rats infused with endotoxin-induced monokines or tumor necrosis factor. Circ Shock 24:111-121
11. Hill M, McCallum R (1991) Altered transcriptional regulation of phosphoenolpyruvate carboxykinase in rats following endotoxin treatment. J Clin Invest. 88:811-816
12. Ardawi MS, Ashy AA, Jamal YS et al (1989) Metabolic control of hepatic gluconeogenesis in response to sepsis. J Lab Clin Med 114:579-586
13. Maitra SR, Gestring ML, ElMaghrabi MR et al (1999) Endotoxin-induced alterations in hepatic glucose-6-phosphatase activity and gene expression. Mol Cell Biochem 196:79-83
14. Giger O, McCallum RE (1976) Reponse of mouse liver glycogen cycle enzymes to endotoxin treatment. Am J Physiol 231:1285-1289
15. Buday AZ, Lang CH, Bagby GJ et al (1986) Glycogen-synthase and phosphorylase activities during glycogen repletion in endotoxemic rats. Circ Shock 19:149-163
16. Liu MS, Kang GF (1987) Liver-glycogen metabolism in endotoxin-shock 2. Endotoxin administration increases glycogen-phosphorylase activities in dog livers. Biochem Med Metab Biol 37:73-80
17. Hamosh M, Shapiro B (1960) The mechanism of glycogenolytic action of endotoxin. Br J Exp Pathol 41:372-380
18. Akira S, Hirano T, Taga T, Kishimoto T (1990) Biology of multifunctional cytokines: IL 6 and related molecules (Il 1 and TNF). FASEB J 4:2860-2867
19. Flores EA, Istfan N, Pomposelli JJ et al (1990) Effect of interleukin-1 and tumour necrosis factor/cachectin on glucose turnover in the rat. Metabolism 39:738-743
20. Chajek-Shaul T, Barash V, Weidenfeld J et al (1990) Lethal hypoglycemia and hypothermia induced by administration of low doses of tumor necrosis factor to adrenalectomized rats. Metabolism 39:242-250
21. Metzger S, Begleibter N, Barash V et al (1997) Tumor necrosis factor inhibits the transcriptional rate of glucose-6- phosphatase in vivo and in vitro. Metabolism 46:579-583
22. Metzger S, Goldschmidt N, Barash V (1997) Interleukin-6 secretion in mice is associated with reduced glucose-6-phosphatase and liver glycogen levels. Am J Physiol 36:E262-E267
23. Ceppi ED, Smith FS, Titheradge MA (1996) Effect of multiple cytokines plus bacterial endotoxin on glucose and nitric oxide production by cultured hepatocytes. Biochem J 317:503-507
24. Ceppi ED, Titheradge MA (1998) The importance of nitric oxide in the cytokine-induced inhibition of glucose formation by cultured hepatocytes incubated with insulin, dexamethasone and glucagon. Arch Biochem Biophys 349:167-174
25. Agius L, Peak M, Alberti KG (1990) Regulation of glycogen synthesis from glucose and gluconeogenic precursors by insulin in periportal and perivenous rat hepatocytes. Biochem J 266:91-102
26. Alegre M, Ciudad CJ, Fillat C et al (1988) Determination of glucose-6-phosphatase activity using the glucose dehydrogenase-coupled reaction. Anal Biochem 173:185-189
27. Vandercammen A, Van Schaftingen E (1993) Species and tissue distribution of the regulatory protein of glucokinase. Biochem J 294:551-556
28. Agius L, Peak M, Newgard CB et al (1996) Evidence for a role of glucose-induced translocation of glucokinase in the control of hepatic glycogen synthesis. J Biol Chem 271:30479-30486
29. Hue L, Bontemps F, Hers HG (1975) The effect of glucose and potassium ions on the conversion of the two forms of glycogen phosphorylase and of glycogen synthetase in isolated rat liver preparations. Biochem J 152:105-114
30. Uhing RJ, Janski AM, Graves DJ (1979) The effect of solvents on nucleotide regulation of glycogen phosphorylase. J Biol Chem 254:3166-3169
31. Dopere F, Vanstapel F, Stalmans W (1980) Glycogen-synthase phosphatase-activity in rat-liver - 2 protein-components and their requirement for the activation of different types of substrate. Eur J Biochem 104:137-146
32. Welsh GI, Patel JC, Proud CG (1997) Peptide substrates suitable for assaying glycogen synthase kinase-3 in crude cell extracts. Anal Biochem 244:16-21
33. Smith FS, Ceppi ED, Titheradge MA (1997) Inhibition of cytokine-induced inducible nitric oxide synthase expression by glucagon and cAMP in cultured hepatocytes. Biochem J 326:187-192
34. Smith PK, Krohn RI, Hermanson GT et al (1985) Measurement of protein using bicinchoninic acid. Anal Biochem 150:76-85
35. Curran RD, Billiar TR, Stuehr DJ et al (1990) Multiple cytokines are required to induce hepatocyte nitric oxide production and inhibit total protein synthesis. Ann Surg 212:462-469
36. Horton RA, Ceppi ED, Knowles RG et al (1994) Inhibition of hepatic gluconeogenesis by nitric oxide: A comparison with endotoxic shock. Biochem J 299:735-739
37. Sprangers F, Sauerwein HP, Romijn JA (1998) Nitric oxide inhibits glycogen synthesis in isolated rat hepatocytes. Biochem J 330:1045-1049
38. Watford M (1988) What is the metabolic-fate of dietary glucose. Trends Biochem Sci 13:329-330
39. Tosh D, Beresford G, Agius L (1994) Glycogen-synthesis from glucose by direct and indirect pathways in hepatocyte cultures from different nutritional states. Biochim Biophys Acta 1224:205-212
40. Agius L, Tosh D, Peak M (1993) The contribution of pyruvate cycling to loss of [6-3H]glucose during conversion of glucose to glycogen in hepatocytes: Effects of insulin, glucose and acinar origin of hepatocytes. Biochem J 289:255-262
41. Nordlie RC, Bode AM, Foster JD (1993) Recent advances in hepatic glucose 6-phosphatase regulation and function. Proc Soc Exp Biol Med 203:274-285
42. Tosh D, Agius L (1995) Lactate and pyruvate stimulate the conversion of glucose to glycogen In hepatocytes by a mechanism that does not involve gluconeogenic flux. Biochim Biophys Acta 1268:165-170
43. Agius L, Chowdhury MH, Davis SN et al (1986) Regulation of ketogenesis, gluconeogenesis, and glycogen synthesis by insulin and proinsulin in rat hepatocyte monolayer cultures. Diabetes 35:1286-1293
44. Arnold J, Hamer MJ, Irving M (1991) Hepatic phosphofructokinase-1 activity and fructose 2,6-bisphosphate levels in patients with abdominal sepsis. Clin Sci 80:213-217
45. Horton RA, Knowles RG, Titheradge MA (1994) Endotoxin causes reciprocal changes in hepatic nitric oxide synthesis, gluconeogenesis, and flux through phosphoenolpyruvate carboxykinase. Biochem Biophys Res Commun 204:659-665
46. Stadler J, Billiar TR, Curran RD (1991) Effect of exogenous and endogenous nitric oxide on mitochondrial respiration of rat hepatocytes. Am J Physiol 260:C910-C916
47. Brown GC (2001) Regulation of mitochondrial respiration by nitric oxide inhibition of cytochrome c oxidase. Biochim Biophys Acta 1504:46-57
48. Vaartjes WJ, de Haas CG, Houweling M (1990) Acute effects of interleukin 1 alpha and 6 on intermediary metabolism in freshly isolated rat hepatocytes. Biochem Biophys Res Commun 169:623-628
49. Aiston S, Hampson L, Gomez-Foix AM et al (2001) Hepatic glycogen synthesis is highly sensitive to phosphorylase activity - evidence from metabolic control analysis. J Biol Chem 276:23858-23866
50. Bollen M, Keppens S, Stalmans W (1998) Specific features of glycogen metabolism in the liver. Biochem J 336:19-31
51. Solling H (1979) Studies on the allosteric properties of glycogen synthase-I. Eur J Biochem 94:231-242
52. Cao YJ, Skurat AV, DePaoli-Roach AA et al (1993) Initiation of glycogen-synthesis - control of glycogenin by glycogen-phosphorylase. J Biol Chem 268:21717-21721
53. Bitensky MW, Gorman RE, Thomas L (1971) Selective stimulation of epinephrine-responsive adenyl cyclase in mice by endotoxin. Proc Soc Exp Biol Med 138:773-775
54. 2+ and glycogen phosphorylase in endotoxicosis and sepsis. Am J Physiol 251:R984-R995
55. Halse R, Fryer LGD, McCormack JG et al (2003) Regulation of glycogen synthase by glucose and glycogen - a possible role for AMP-activated protein kinase. Diabetes 52:9-15
56. Pencek RR, Shearer J, Camacho RC et al (2005) 5-Aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside causes acute hepatic insulin resistance in vivo. Diabetes 54:355-360
57. Vary TC, Deiter G, Kimball SR (2002) Phosphorylation of eukaryotic initiation factor eIF2B epsilon in skeletal muscle during sepsis. Am J Physiol 283:E1032-E1039
58. VillarPalasi C, Guinovart JJ (1997) The role of glucose 6-phosphate in the control of glycogen synthase. FASEB J 11:544-558
59. Mori E, Hasebe M, Kobayashi K et al (1987) Alterations in metabolite levels in carbohydrate and energy metabolism of rat in hemorrhagic shock and sepsis. Metabolism 36:14-20
60. Ferrer JC, Favre C, Gomis RR et al (2003) Control of glycogen deposition. FEBS Lett 546:127-132
61. Fernandez-Novell JM, Arino J, Vilaro S et al (1992) Role of glucose-6-phosphate in the translocation of glycogen- synthase in rat hepatocytes. Biochem J 288:497-501