The bacterial toxin RelE induces specific mRNA cleavage in the A site of the eukaryote ribosome

RNA

Volumn 14, Issue 2, 2008, Pages 233-239

  Andreev, Dmitri ^a   Hauryliuk, Vasili ^b   Terenin, Ilya ^a   Dmitriev, Sergey ^a   Ehrenberg, Måns ^b   Shatsky, Ivan ^a  

^a MOSCOW STATE UNIVERSITY   (Russian Federation)

^b UPPSALA UNIVERSITY   (Sweden)

Author keywords

Bacterial toxin RelE; Eukaryotic ribosomes; Initiation complex assembly; mRNA cleavage; RelE printing; Toeprinting

Indexed keywords

BACTERIAL TOXIN; BACTERIAL TOXIN RELE; MESSENGER RNA; UNCLASSIFIED DRUG;

ARTICLE; BINDING SITE; CELL LYSATE; EUKARYOTE; HEPATITIS C VIRUS; HUMAN; NONHUMAN; PRIORITY JOURNAL; RABBIT; REGULATORY RNA SEQUENCE; RIBOSOME; RNA CLEAVAGE;

ANIMALS; BACTERIAL TOXINS; BASE SEQUENCE; ESCHERICHIA COLI PROTEINS; GENETIC TECHNIQUES; HEPACIVIRUS; PROTEIN BIOSYNTHESIS; RABBITS; RETICULOCYTES; RIBOSOMES; RNA, MESSENGER; RNA, TRANSFER; RNA, VIRAL;

BACTERIA (MICROORGANISMS); EUKARYOTA;

EID: 38649111610     PISSN: 13558382     EISSN: 14699001     Source Type: Journal    
DOI: 10.1261/rna.693208     Document Type: Article

References (27)

1. Anantharaman, V. and Aravind, L. 2003. New connections in the prokaryotic toxin-antitoxin network: Relationship with the eukaryotic nonsense-mediated RNA decay system. Genome Biol. 4: R81. doi: 10.1186/gb-2003-4-12-r81.
2. Andreev, D.E., Terenin, I.M., Dunaevsky, Y.E., Dmitriev, S.E., and Shatsky, I.N. 2006. A leaderless mRNA can bind to mammalian 80S ribosomes and direct polypeptide synthesis in the absence of translation initiation factors. Mol. Cell. Biol. 26: 3164-3169.
3. Andreev, D.E., Fernandez-Miragall, O., Ramajo, J., Dmitriev, S.E., Terenin, I.M., Martinez-Salas, E., and Shatsky, I.N. 2007. Differential factor requirement to assemble translation initiation complexes at the alternative start codons of foot-and-mouth disease virus RNA. RNA 13: 1366-1374.
4. Bech, F.W., Jorgensen, S.T., Diderichsen, B., and Karlstrom, O.H. 1985. Sequence of the relB transcription unit from Escherichia coli and identification of the relB gene. EMBO J. 4: 1059-1066.
5. Belsham, G.J. and Jackson, R.J. 2000. Translation initiation on picornavirus RNA. In Translational control of gene expression (eds. N. Sonenberg et al.), pp. 869-900. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
6. Borman, A.M., Bailly, J.-L., Girard, M., and Kean, K.M. 1995. Picornavirus internal ribosome entry segments: Comparison of translation efficiency and the requirements for optimal internal initiation of translation in vitro. Nucleic Acids Res. 23: 3656-3663. doi: 10.1093/nar/23.18.3656.
7. Cheung, Y.N., Maa, D., Mitchell, S.F., Fekete, C.A., Algire, M.A., Takacs, J.E., Shirokikh, N., Pestova, T., Lorsch, J.R., and Hinnebusch, A.G. 2007. Dissociation of eIF1 from the 40S ribosomal subunit is a key step in start codon selection in vivo. Genes & Dev. 21: 1217-1230.
8. Christensen, S.K., Mikkelsen, M., Pedersen, K., and Gerdes, K. 2001. RelE, a global inhibitor of translation, is activated during nutritional stress. Proc. Natl. Acad. Sci. 98: 14328-14333.
9. Dmitriev, S.E., Pisarev, A.V., Rubtsova, M.P., Dunaevsky, Y.E., and Shatsky, I.N. 2003. Conversion of 48S translation preinitiation complexes into 80S initiation complexes as revealed by toeprinting. FEBS Lett. 533: 99-104.
10. Dmitriev, S.E., Andreev, D.E., Terenin, I.M., Olovnikov, I.A., Prassolov, V.S., Merrick, W.C., and Shatsky, I.N. 2007. Efficient translation initiation directed by the 900-nucleotide-long and GCrich 5′ untranslated region of the human retrotransposon LINE-1 mRNA is strictly cap dependent rather than internal ribosome entry site mediated. Mol. Cell. Biol. 27: 4685-4697.
11. Doma, M.K. and Parker, R. 2006. Endonucleolytic cleavage of eukaryotic mRNAs with stalls in translation elongation. Nature 440: 561-564.
12. Gerdes, K. 2000. Toxin-antitoxin modules may regulate synthesis of macromolecules during nutritional stress. J. Bacteriol. 182: 561-572.
13. Gerdes, K., Christensen, S.K., and Lobner-Olesen, A. 2005. Prokaryotic toxin-antitoxin stress response loci. Nat. Rev. Microbiol. 3: 371-382.
14. Jelenc, P.C. and Kurland, C.G. 1979. Nucleoside triphosphate regeneration decreases the frequency of translation errors. Proc. Natl. Acad. Sci. 76: 3174-3178.
15. Kristoffersen, P., Jensen, G.B., Gerdes, K., and Piskur, J. 2000. Bacterial toxin-antitoxin gene system as containment control in yeast cells. Appl. Environ. Microbiol. 66: 5524-5526.
16. Lomakin, I.B., Shirokikh, N.E., Yusupov, M.M., Hellen, C.U.T., and Pestova, T.V. 2006. The fidelity of translation initiation: Reciprocal activities of eIF1, IF3, and YciH. EMBO J. 25: 196-210.
17. Obrig, T.G., Culp, W.J., McKeehan, W.L., and Hardesty, B. 1971. The mechanism by which cycloheximide and related glutarimide antibiotics inhibit peptide synthesis on reticulocyte ribosomes. J. Biol. Chem. 246: 174-181.
18. Pedersen, K., Christensen, S.K., and Gerdes, K. 2002. Rapid induction and reversal of a bacteriostatic condition by controlled expression of toxins and antitoxins. Mol. Microbiol. 45: 501-510.
19. Pedersen, K., Zavialov, A.V., Pavlov, M.Y., Elf, J., Gerdes, K., and Ehrenberg, M. 2003. The bacterial toxin RelE displays codon-specific cleavage of mRNAs in the ribosomal A site. Cell 112: 131-140.
20. Pestova, T.V. and Kolupaeva, V.G. 2002. The roles of individual eukaryotic translation initiation factors in ribosomal scanning and initiation codon selection. Genes & Dev. 16: 2906-2922.
21. Pestova, T.V., Hellen, C.U., and Shatsky, I.N. 1996. Canonical eukaryotic initiation factors determine initiation of translation by internal ribosomal entry. Mol. Cell. Biol. 16: 6859-6869.
22. Pestova, T.V., Borukhov, S.I., and Hellen, C.U. 1998a. Eukaryotic ribosomes require initiation factors 1 and 1A to locate initiation codons. Nature 394: 854-859.
23. Pestova, T.V., Shatsky, I.N., Fletcher, S.P., Jackson, R.J., and Hellen, C.U. 1998b. A prokaryotic-like mode of cytoplasmic eukaryotic ribosome binding to the initiation codon during internal translation initiation of hepatitis C and classical swine fever virus RNAs. Genes & Dev. 12: 67-83.
24. Takagi, H., Kakuta, Y., Okada, T., Yao, M., Tanaka, I., and Kimura, M. 2005. Crystal structure of archaeal toxin-antitoxin RelE-RelB complex with implications for toxin activity and antitoxin effects. Nat. Struct. Mol. Biol. 12: 327-331.
25. Yamamoto, T.A., Gerdes, K., and Tunnacliffe, A. 2002. Bacterial toxin RelE induces apoptosis in human cells. FEBS Lett. 519: 191-194.
26. Zavialov, A.V., Hauryliuk, V.V., and Ehrenberg, M. 2005a. Guanine-nucleotide exchange on ribosome-bound elongation factor G initiates the translocation of tRNAs. J. Biol. 4: 9.
27. Zavialov, A.V., Hauryliuk, V.V., and Ehrenberg, M. 2005b. Splitting of the posttermination ribosome into subunits by the concerted action of RRF and EF-G. Mol. Cell 18: 675-686.