Symptom-limited exercise combined with dipyridamole stress: Prognostic value in assessment of known or suspected coronary artery disease by use of gated SPECT imaging

Journal of Nuclear Cardiology

Volumn 15, Issue 1, 2008, Pages 42-56

  Ahlberg, Alan W ^a   Baghdasarian, Sarkis B ^a   Athar, Haris ^a   Thompsen, Jeffrey P ^a   Katten, Deborah M ^a   Noble, Gavin L ^a   Mamkin, Igor ^a   Shah, Anuj R ^a   Leka, Ivette A ^a   Heller, Gary V ^a  

^a HARTFORD HOSPITAL   (United States)

Author keywords

dipyridamole; gated SPECT; risk stratification; Symptom limited exercise

Indexed keywords

AMINOPHYLLINE; DIPYRIDAMOLE; METHOXY ISOBUTYL ISONITRILE TECHNETIUM TC 99M; VASODILATOR AGENT;

ADULT; ARTICLE; CLINICAL ASSESSMENT; CLINICAL PROTOCOL; COHORT ANALYSIS; CONTROLLED STUDY; CORONARY ARTERY DISEASE; DIAGNOSTIC IMAGING; EXERCISE TEST; FEMALE; FUNCTIONAL STATUS; GATED IMAGING; HEART DEATH; HEART EJECTION FRACTION; HEART INFARCTION; HEART MUSCLE ISCHEMIA; HUMAN; IMAGE QUALITY; MAJOR CLINICAL STUDY; MALE; OUTCOME ASSESSMENT; PATIENT CODING; PHARMACOLOGIC STRESS TESTING; PREDICTION; PRIORITY JOURNAL; PROGNOSIS; PROPORTIONAL HAZARDS MODEL; RISK ASSESSMENT; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY;

ADULT; AGED; AGED, 80 AND OVER; CONNECTICUT; CORONARY ARTERY DISEASE; DIPYRIDAMOLE; EXERCISE TEST; FEMALE; GATED BLOOD-POOL IMAGING; HUMANS; IMAGE ENHANCEMENT; MALE; MIDDLE AGED; PREVALENCE; PROGNOSIS; TOMOGRAPHY, EMISSION-COMPUTED, SINGLE-PHOTON; VASODILATOR AGENTS;

EID: 38649107333     PISSN: 10713581     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.nuclcard.2007.09.025     Document Type: Article

References (63)

1. Sharir T., Germano G., Kavanaugh P.B., Lai Shenhan, Cohen I., Lewin H.C., et al. Incremental prognostic value of post-stress left ventricular ejection fraction and volume by gated myocardial perfusion single photon emission computed tomography. Circulation 100 (1999) 1035-1042
2. Sharir T., Germano G., Kang X., Lewin H.C., Miranda R., Cohen I., et al. Prediction of myocardial infarction versus cardiac death by gated myocardial perfusion SPECT: risk stratification by the amount of stress-induced ischemia and the post-stress ejection fraction. J Nucl Med 42 (2001) 831-837
3. Travin M.I., Heller G.V., Johnson L.L., Katten D., Ahlberg A.W., Isasi C.R., et al. The prognostic value of ECG-gated SPECT imaging in patients undergoing stress Tc-99m sestamibi myocardial perfusion imaging. J Nucl Cardiol 11 (2004) 253-262
4. Thomas G.S., Miyamoto M.I., Morello A.P., Majmundar H., Thomas J.J., Sampson C.H., et al. Technetium-99m sestamibi myocardial perfusion imaging predicts clinical outcome in the community outpatient setting: the Nuclear Utility in the Community (NUC) Study. J Am Coll Cardiol 43 (2004) 213-223
5. Petix N.R., Sestini S., Marcucci G., Coppola A., Arena A., Nassi F., et al. Can the reversible regional wall motion abnormalities on stress gated Tc-99m sestamibi SPECT predict a future cardiac event?. J Nucl Cardiol 12 (2005) 20-31
6. Petix N.R., Sestini S., Coppola A., Marcucci G., Nassi F., Taiti A., et al. Prognostic value of combined perfusion and function by stress technetium-99m sestamibi gated SPECT myocardial perfusion imaging in patients with suspected or known coronary artery disease. Am J Cardiol 95 (2005) 1351-1357
7. Navare S.M., Katten D., Johnson L.L., Mather J.F., Fowler M.S., Ahlberg A.W., et al. Risk stratification with electrocardiographic-gated dobutamine stress technetium-99m sestamibi single-photon emission tomographic imaging: value of heart rate response and assessment of left ventricular function. J Am Coll Cardiol 47 (2006) 781-788
8. Sharir T., Kang X., Germano G., Bax J.J., Shaw L.J., Gransar H., et al. Prognostic value of poststress left ventricular volume and ejection fraction by gated myocardial perfusion SPECT in women and men: gender-related differences in normal limits and outcomes. J Nucl Cardiol 13 (2006) 495-506
9. Hachamovitch R., Rozanski A., Hayes S.W., Thomson L.E.J., Germano G., Friedman J.D., et al. Predicting therapeutic benefit from myocardial revascularization procedures: are measurements of both resting left ventricular ejection fraction and stress-induced myocardial ischemia necessary?. J Nucl Cardiol 13 (2006) 768-778
10. Iskandrian A.S., Chae S.C., Heo J., Stanberry C.D., Wasserleben V., and Cave V. Independent and incremental prognostic value of exercise single-photon emission computed tomographic (SPECT) thallium imaging in coronary artery disease. J Am Coll Cardiol 22 (1993) 665-670
11. Travin M.I., Boucher C.A., Newell J.B., LaRaia P.J., Flores A.R., and Eagle K.A. Variables associated with a poor prognosis in patients with an ischemic thallium-201 exercise test. Am Heart J 125 (1993) 335-344
12. Snader C.E., Marwick T.H., Pashkow F.J., Harvey S.A., Thomas J.D., and Lauer M.S. Importance of estimated functional capacity as a predictor of all-cause mortality among patients referred for exercise thallium single-photon emission computed tomography: report of 3,400 patients from a single center. J Am Coll Cardiol 30 (1997) 641-648
13. Diaz L.A., Brunken R.C., Blackstone E.H., Snader C.E., and Lauer M.S. Independent contribution of myocardial perfusion defects to exercise capacity and heart rate recovery for prediction of all-cause mortality in patients with known or suspected coronary heart disease. J Am Coll Cardiol 37 (2001) 1558-1564
14. Iskandrian A.S., Heo J., Kong B., and Lyons E. Effect of exercise level on the ability of thallium-201 tomographic imaging in detecting coronary artery disease: analysis of 461 patients. J Am Coll Cardiol 14 (1989) 1477-1486
15. Heller G.V., Ahmed I., Tilkemeier P.L., Barbour M.M., and Garber C.E. Influence of exercise intensity on the presence, distribution, and size of thallium-201 defects. Am Heart J 123 (1992) 909-916
16. Beller G.A. Dipyridamole thallium-201 scintigraphy: an excellent alternative to exercise scintigraphy. J Am Coll Cardiol 14 (1989) 1642-1644
17. Nguyen T., Heo J., Ogilby J.D., and Iskandrian A.S. Single photon emission computed tomography with thallium-201 during adenosine-induced coronary hyperemia: correlation with coronary arteriography, exercise thallium imaging and two-dimensional echocardiography. J Am Coll Cardiol 16 (1990) 1375-1383
18. Coyne E.P., Belvedere D.A., Vande Streek P.R., Weiland F.L., Evans R.B., and Spaccavento L.J. Thallium-201 scintigraphy after intravenous infusion of adenosine compared with exercise thallium testing in the diagnosis of coronary artery disease. J Am Coll Cardiol 17 (1991) 1289-1294
19. Gupta N.C., Esterbrooks D.J., Hilleman D.E., and Mohiuddin S.M. Comparison of adenosine and exercise thallium-201 single-photon emission computed tomography (SPECT) myocardial perfusion imaging. J Am Coll Cardiol 19 (1992) 248-257
20. Nishimura S., Mahmarian J.J., Boyce T.M., and Verani M.S. Equivalence between adenosine and exercise thallium-201 myocardial tomography: a multicenter, prospective crossover trial. J Am Coll Cardiol 20 (1992) 265-275
21. Miller D.D., Younis L.T., Chaitman B.R., and Sratmann H. Diagnostic accuracy of dipyridamole technetium99m-labeled sestamibi myocardial tomography for detection of coronary artery disease. J Nucl Cardiol 4 (1997) 18-24
22. Stratmann H.G., Tamesis B.R., Younis L.T., Wittry M.D., and Miller D.D. Prognostic value of dipyridamole technetium-99m sestamibi myocardial tomography in patients with stable chest pain who are unable to exercise. Am J Cardiol 73 (1994) 647-652
23. Miller D.D., Stratmann H.G., Shaw L., Tamesis B.R., Wittry M.D., Younis L.T., et al. Dipyridamole technetium 99m sestamibi myocardial tomography as an independent predictor of cardiac event-free survival after acute ischemic events. J Nucl Cardiol 1 (1994) 72-82
24. Heller G.V., Herman S.D., Travin M.I., Baron J.I., Santos-Ocampo C., and McClellan J.R. Independent prognostic value of intravenous dipyridamole with technetium-99m sestamibi tomographic imaging in predicting cardiac events and cardiac-related hospital admissions. J Am Coll Cardiol 26 (1995) 1202-1208
25. Stratmann H.G., Tamesis B.R., Younis L.T., Wittry M.D., Amato M., and Miller D.D. Prognostic value of predischarge dipyridamole technetium 99m sestamibi myocardial tomography in medically treated patients with unstable angina. Am Heart J 130 (1995) 734-740
26. Stratmann H.G., Younis L.T., Wittry M.D., Amato M., and Miller D.D. Dipyridamole technetium-99m sestamibi myocardial tomography in patients evaluated for elective vascular surgery: prognostic value of perioperative and late cardiac events. Am Heart J 131 (1996) 923-929
27. McClellan J.R., Travin M.I., Herman S.D., Baron J.I., Golub R.J., Gallagher J.J., et al. Prognostic importance of scintigraphic left ventricular cavity dilation during intravenous dipyridamole technetium-99m sestamibi myocardial tomographic imaging in predicting coronary events. Am J Cardiol 79 (1997) 600-605
28. Hachamovitch R., Berman D.S., Kiat H., Cohen I., Lewin H., Amanullah A., et al. Incremental prognostic value of adenosine stress myocardial perfusion single-photon emission computed tomography and impact on subsequent management in patients with or suspected of having myocardial ischemia. Am J Cardiol 80 (1997) 426-433
29. Hachamovitch R., Hayes S.W., Friedman J.D., Cohen I., and Berman D.S. A progressive score for prediction of cardiac mortality risk after adenosine stress myocardial perfusion scintigraphy. J Am Coll Cardiol 45 (2005) 722-729
30. Laarman G.J., Bruschke A.V.G., Verzijlbergen J.F., Bal E.T., van der Wall E.E., and Ascoop C.A. Efficacy of intravenous dipyridamole with exercise thallium-201 myocardial perfusion scintigraphy. Eur Heart J (1988) 1206-1214
31. Casale P.N., Guiney T.E., Strauss H.W., and Boucher C.A. Simultaneous low level treadmill exercise and intravenous dipyridamole stress thallium imaging. Am J Cardiol 62 (1988) 799-802
32. Laarman G.J., Bruschke A.V.G., Verzijibergen J.F., Go T.L., Bal E.T., Van Der Wall E.E., et al. Thallium-201 scintigraphy after dipyridamole infusion with low-level exercise. II. Quantitative analysis vs. visual analysis. Eur Heart J 11 (1990) 162-172
33. Laarman G.J., Serruys P.W., Verzijlbergen J.F., and Ascoop C.A. Thallium-201 scintigraphy after dipyridamole infusion with low-level exercise. III. Clinical significance and additional diagnostic value of ST segment depression and angina pectoris during the test. Eur Heart J 11 (1990) 705-711
34. Ignaszewski A.P., McCormick L.X., Heslip P.G., McEwan A.J., and Humen D.P. Safety and clinical utility of combined intravenous dipyridamole/symptom-limited exercise stress test with thallium-201 imaging in patients with known or suspected coronary artery disease. J Nucl Med 34 (1993) 2053-2061
35. Pennell D.J., Mavrogeni S.I., Forbat S.M., Karwatowski S.P., and Underwood S.R. Adenosine combined with dynamic exercise for myocardial perfusion imaging. J Am Coll Cardiol 25 (1995) 1300-1309
36. Stein L., Burt R., Oppenheim B., Schauwecker D., and Fineberg N. Symptom-limited arm exercise increases detection of ischemia during dipyridamole tomographic thallium stress testing in patients with coronary artery disease. Am J Cardiol 75 (1995) 568-572
37. Daou D., Le Guiudec D., Faraggi M., Foult J.M., Lebtahi R., Cohen-Solal A., et al. Nonlimited exercise test combined with high-dose dipyridamole for thallium-201 myocardial single-photon emission computed tomography in coronary artery disease. Am J Cardiol 76 (1995) 753-758
38. Elliott M.D., Holly T.A., Leonard S.M., and Hendel R.C. Impact of an abbreviated adenosine protocol incorporating adjunctive treadmill exercise on adverse effects and image quality in patients undergoing stress myocardial perfusion imaging. J Nucl Cardiol 7 (2000) 584-589
39. Thomas G.S., Prill N.V., Majmundar H., Fabrizi R.R., Thomas J.J., Hayashida C., et al. Treadmill exercise during adenosine infusion is safe, results in fewer adverse reactions, and improves myocardial perfusion image quality. J Nucl Cardiol 7 (2000) 439-446
40. Vitola J.V., Brambatti J.C., Caligaris F., Lesse C.R., Nogueira P.R., Joaquim A.I., et al. Exercise supplementation to dipyridamole prevents hypotension, improves electrocardiogram sensitivity, and increases heart-to-liver activity ratio on Tc-99m sestamibi imaging. J Nucl Cardiol 8 (2001) 652-659
41. Samady H., Wackers F.J., Joska T.M., Zaret B.L., and Jain D. Pharmacologic stress perfusion imaging with adenosine: role of simultaneous low-level treadmill exercise. J Nucl Cardiol 9 (2002) 188-196
42. Verzijibergen J.F., Vermeersch P.H., Laarman G.J., and Ascoop C.A. Inadequate exercise leads to suboptimal imaging. Thallium-201 myocardial perfusion imaging after dipyridamole combined with low-level exercise unmasks ischemia in symptomatic patients with non-diagnostic thallium-201 scans who exercise submaximally. J Nucl Med 32 (1991) 2071-2078
43. Pennell D.J., Mavrogeni S., Anagnostopoulos C., Ell P.J., and Underwood S.R. Thallium myocardial perfusion tomography using intravenous dipyridamole combined with maximal dynamic exercise. Nucl Med Commun 14 (1993) 939-945
44. Candell-Riera J., Santana-Boado C., Castell-Conesa J., Aguade-Bruix S., Olona M., Palet J., et al. Simultaneous dipyridamole/maximal subjective exercise with 99mTc-MIBI SPECT: improved diagnostic yield in coronary artery disease. J Am Coll Cardiol 29 (1997) 531-536
45. Holly T.A., Satran A., Bromet D.S., Mieres J.H., Frey M.J., Elliott M.D., et al. The impact of adjunctive adenosine infusion during exercise myocardial perfusion imaging: results of the Both Exercise and Adenosine Stress Test (BEAST) Trial. J Nucl Cardiol 10 (2003) 291-296
46. Gibbons R.J., Balady G.J., Beasley J.W., Bricker J.T., Duvernoy W.F., Froelicher V.F., et al. ACC/AHA guidelines for exercise testing: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Committee on Exercise Testing). J Am Coll Cardiol 30 (1997) 260-315
47. McArdle W.D., Katch F.I., and Katch W.L. Essentials of exercise physiology (1994), Lea & Febiger, Philadelphia 354
48. American Society of Nuclear Cardiology. Imaging guidelines for nuclear cardiology procedures, part 2. J Nucl Cardiol 6 (1999) G47-G84
49. Cerqueria M.D., Weissman N.J., Dilsizian V., Jacobs A.K., Kaul S., and Laskey W.K. Standardized myocardial segmentation and nomenclature for tomographic imaging of the heart: a statement for healthcare professionals from the Cardiac Imaging Committee of the Council on Clinical Cardiology of the American Heart Association. Circulation 105 (2002) 539-542
50. Germano G., Kiat H., Kavanaugh P.B., Moriel M., Mazzanti M., and Hsiao-Te S. Automatic quantification of ejection fraction from gated myocardial perfusion SPECT. J Nucl Med 36 (1995) 2138-2147
51. Brown K.A. Exercise-dipryidamole myocardial perfusion imaging: the circle is now complete-editorial. J Nucl Med 34 (1993) 2053-2061
52. Boden W.E., O'Rourke R.A., Teo K.K., Hartigan P.M., Maron D.J., and Kostuk W.J. Optimal medical therapy with or without PCI for stable coronary disease. N Engl J Med 356 (2007) 1-14
53. 2A receptor agonist binodenoson for pharmacological stress as an adjunct to myocardial perfusion imaging. Circulation 109 (2004) 457-465
54. Hockings B., Saltissi S., Croft D.N., and Webb-Peploe M.M. Effect of beta adrenergic blockade on thallium-201 myocardial perfusion imaging. Br Heart J 48 (1983) 83-89
55. Martin G.J., Henkin R.E., and Scanlon P.J. Beta blockers and the sensitivity of the thallium treadmill test. Chest 92 (1987) 486-487
56. Taillefer R., Ahlberg A.W., Masood Y., White C.M., Lamargese I., Mather J.P., et al. Acute beta-blockade reduces the extent and severity of myocardial perfusion defects with dipyridamole Tc-99m sestamibi SPECT imaging. J Am Coll Cardiol 42 (2003) 1475-1483
57. Brown K.A., and Rowen M.A. Impact of antianginal medications, peak heart rate, and stress level on the prognostic value of a normal exercise myocardial perfusion imaging study. J Nucl Med 34 (1993) 1467-1471
58. Burns R.J., Kruzyk G.C., Armitage D.L., and Druck M.N. Effect of antianginal medications on the prognostic value of exercise thallium scintigraphy. Can J Cardiol 5 (1989) 29-32
59. Gerson M.C. Reduction in dipyridamole-induced single-photon emission computed tomography myocardial defect size by beta-blockers-editorial. J Am Coll Cardiol 42 (2003) 1484-1486
60. Alderman E.L., Coltart D.J., Wettach G.E., and Harrison D.C. Coronary artery syndromes after sudden propranolol withdrawal. Ann Intern Med 81 (1974) 625-627
61. Miller R.R., Olson H.G., Amsterdam E.A., and Mason D.T. Propranolol-withdrawal rebound phenomenon. Exacerbation of coronary events after abrupt cessation of antianginal therapy. N Engl J Med 293 (1975) 416-418
62. Myers M.G., and Wisenberg G. Sudden withdrawal of propranolol in patients with angina pectoris. Chest 71 (1977) 24-26
63. Lindenfield J., Crawford M.H., O'Rourke R.A., Levine S.P., Montiel M.M., and Horowitz L.D. Adrenergic responsiveness after abrupt propranolol withdrawal in normal subjects and in patients with angina pectoris. Circulation 62 (1980) 704-711