Synthesis of a novel multivalent galactoside with high hepatocyte targeting for gene delivery

Chinese Chemical Letters

Volumn 19, Issue 2, 2008, Pages 127-129

  Jiang, Qing Lin ^a   Hai, Li ^a   Chen, Lei ^a   Lu, Jiao ^a   Zhang, Zhi Rong ^a   Wu, Yong ^a  

^a BEIJING UNIVERSITY OF POSTS AND TELECOMMUNICATIONS   (China)

Author keywords

Clustered glycosides; Galactosylated ligand; Gene delivery; Hepatocyte; Targeting

Indexed keywords

EID: 38649106765     PISSN: 10018417     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cclet.2007.12.002     Document Type: Article

References (17)

1. Vogel K., Wang S., Lee R.G., et al. J. Am. Chem. Soc. 118 (1996) 1581
2. Park I.K., Kim T.H., Park Y.H., et al. J. Control. Rel. 76 (2001) 349
3. Kim C.K., Min K.H., Oh Y.K., et al. Int. J. Pharm. 128 (1996) 65
4. Sun X., Hai L., Wu Y., et al. J. Drug Target. 13 2 (2005) 1021
5. Kawakami S., Wong J., Sato A., et al. Biochim. Biophys. Acta 1524 2/3 (2000) 258
6. Ashwell G., and Harford J. Annu. Rev. Biochem. 51 (1982) 531
7. Rensen P.C.N., Sliedregt L.A.J.M., Ferns M., et al. J. Biol. Chem. 276 (2001) 37577
8. Shimada K., Kamps J.A., Regts J., et al. Scherphof. Biochim. Biophys. Acta 1326 (2001) 329
9. Tang L., Wu Y., Lu J., Hai L., et al. Chin. Chem. Lett. 18 5 (2007) 513
10. Biessen E.A., Beuting D.M., Roelen H.C., et al. J. Med. Chem. 38 9 (1995) 1538
11. Sliedregt L.A., Rensen P.C., Rump E.T., et al. J. Med. Chem. 42 4 (1999) 609
12. Iden D.L., and Allen T.M. Biochim. Biophys. Acta 1513 (2001) 207
13. Praefcke K., Psaras P., and Kohne B. Chem. Ber. 124 11 (1991) 2523
14. Hai L., Fan J., Zhang Z.Y., Zhang G.Y., and Wu Y. Synth. Commun. 36 18 (2006) 2633
15. Roelen H.C., Bijsterbosch M.K., Bakkeren H.F., et al. J. Med. Chem. 34 3 (1991) 1036
16. 5: C, 55.20; H, 7.21; S, 5.46. Found: C, 55.49; H, 7.01; S, 5.23.
17. 5: C, 54.42; H, 8.17; S, 7.65; Found: C, 54.66; H, 8.23; S, 7.47.