Experimental toxocariosis in BALB/c mice: Effect of the inoculation dose on brain and eye involvement

Acta Tropica

Volumn 105, Issue 2, 2008, Pages 124-130

  Ollero, María Dolores ^a   Fenoy, Soledad ^a   Cuéllar, Carmen ^b   Guillén, José Luis ^b   del Aguila, Carmen ^b  

^a UNIVERSIDAD SAN PABLO CEU   (Spain)

^b UNIVERSIDAD COMPLUTENSE DE MADRID   (Spain)

Author keywords

Brain; Eye; Larval migration; Multiple doses; Ocular toxocarosis; Single doses; Toxocara canis

Indexed keywords

IMMUNOGLOBULIN G; IMMUNOGLOBULIN G1; IMMUNOGLOBULIN G2A; IMMUNOGLOBULIN G2B; IMMUNOGLOBULIN G3; IMMUNOGLOBULIN M;

ANTIBODY; ANTIGEN; BRAIN; DOSE-RESPONSE RELATIONSHIP; EXPERIMENTAL DESIGN; EYE; IMMUNE RESPONSE; INOCULATION; LARVAL DEVELOPMENT; NEMATODE; PARASITIC DISEASE; RODENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BAGG ALBINO MOUSE; BRAIN INFECTION; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; EYE INFECTION; HUMORAL IMMUNITY; MOUSE; NONHUMAN; TOXOCARA; TOXOCARA CANIS; TOXOCARIASIS; ZYGOTE;

ANIMALS; ANTIBODIES, HELMINTH; BRAIN; CENTRAL NERVOUS SYSTEM HELMINTHIASIS; EYE; EYE INFECTIONS, PARASITIC; FEMALE; HOST-PARASITE INTERACTIONS; LARVA; MICE; MICE, INBRED BALB C; TOXOCARA; TOXOCARIASIS;

ANIMALIA; MUS; TOXOCARA CANIS;

EID: 38649100634     PISSN: 0001706X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.actatropica.2007.11.001     Document Type: Article

References (45)

1. Águila C., Cuéllar C., Fenoy S., and Guillén J.L. Comparative study of assays detecting circulating immune complexes and specific antibodies in patients infected with Toxocara canis. J. Helminthol. 6l (1987) 196-202
2. Akao N., Takayanagi T.H., Suzuki R., Tsukidate S., and Fujita K. Ocular larva migrans caused by Toxocara cati in Mongolian gerbils and a comparison of ophthalmologic findings with those produced by T. canis. J. Parasitol. 86 (2000) 1133-1135
3. Alba-Hurtado F., Tortora P.J., Tsutsumi V., and Ortega-Pierres M.G. Histopathological investigation of experimental ocular toxocariasis in gerbils. Int. J. Parasitol. 30 (2000) 143-147
4. Bardón R., Cuéllar C., and Guillén J.L. Larval distribution of Toxocara canis in BALB/c mice at nine weeks and one year post-inoculation. J. Helminthol. 68 (1994) 359-360
5. Bardón R., Cuellar C., and Guillen J.L. Evaluation by larval recovery of mebendazole activity in experimental murine toxocariasis. Int. J. Parasitol. 25 (1995) 587-592
6. Bowman D.D., Mika-Grieve M., and Grieve R.B. Circulating excretory-secretory antigen levels and specific IgG and IgM responses in mice infected with Toxocara canis. Am. J. Trop. Med. Hyg. 36 (1987) 75-82
7. Bradford M. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye-binding. Anal. Biochem. 72 (1976) 248
8. Cox D.M., and Holland C.V. Relationship between three intensity levels of Toxocara canis larvae in the brain and effects on exploration, anxiety, learning and memory in the murine host. J. Helminthol. 75 (1998) 33-41
9. Cuéllar C., Fenoy S., Águila del C., and Guillén J.L. Nuevos datos sobre la fotodependencia del desarrollo embrionario de Toxocara canis. Rev. Iber. Parasitol. 46 (1986) 409-417
10. Cuéllar C., Fenoy S., Águila C., and Guillén J.L. lsotype specific immune responses in murine experimental toxocariasis. Mem. Inst. Oswaldo Cruz 96 (2001) 549-553
11. Cypess R.H., Karol M.H., Zidian J.L., Glikman L.T., and Gitlin D. Larva-specific antibodies in patients with visceral larva migrans. J. Infect. Dis. 135 (1977) 633-640
12. de Savigny D.H. In vitro maintenance of Toxocara canis larvae and a simple method for the production of Toxocara E/S antigen for the use in serodiagnostic tests for visceral larva migrans. J. Parasitol. 61 (1975) 781-782
13. Despommier D. Toxocariasis: clinical aspects, epidemiology, medical ecology, and molecular aspects. Clin. Microbiol. Rev. 16 (2003) 265-272
14. Duguid I.M. Chronic endophthalmitis due to Toxocara. Br. J. Ophtalmol. 45 (1961) 705-717
15. Epe C., Sabel T., Schnieder T., and Stoye M. The behavior and pathogenicity of Toxocara canis larvae in mice of different strains. Parasitol. Res. 80 (1994) 691-695
16. Farjat J.A., Minvielle M.C., Pezzani B.C., and Niedfeld G. Relationship between parasitical inoculum and immunological parameters in experimental toxocariasis. Zentralbl. Bakteriol. 282 (1995) 465-473
17. Fenoy S., Cuéllar C., Águila C., and Guillén J.L. Persistence of immune response in human toxocariasis as measured by ELISA. Int. J. Parasitol. 22 (1992) 1037-1038
18. Ghafoor S.Y.A., Smith H.V., Lee W.R., Quinn R., and Girdwood R.W.A. Experimental ocular toxocariasis in a mouse model. Br. J. Ophtalmol. 68 (1984) 89-96
19. Glickman L.T., and Schantz P.M. Epidemiology and pathogenesis of zoonotic toxocariasis. Epidemiol. Rev. 3 (1981) 230-250
20. Glickman L.T., Magnaval J.F., and Brochier B. Seroprevalence of visceral larva migrans in the Mediterranean Pyrinean region. Presse Med. 14 (1985) 1094
21. Good B., Holland C.V., and Stafford P. The influence of inoculum size and time post-infection on the number and position of Toxocara canis larvae recovered from the brains of outbred CDI mice. J. Helminthol. 75 (2001) 175-181
22. Good B., Holland C.V., Taylor M.R.H., Larragy J., Moriarty P., and O'Regan M. Ocular toxocariasis in schoolchildren. Clin. Infect. Dis. 39 (2004) 173-178
23. Guillén J.L., Cuéllar C., and Águila C. Larva migratoria visceral: estudio mediante ELISA de tres grupos familiares. Pediatrika 6 (1986) 28-32
24. Guillén J.L., Bardón R., Dominguez P., and Cuellar C. Migración larvaria de Toxocara canis y respuesta eosinofilica en las cepas murinas BALB/c y C57BL/I0. Rev. Iber. Parasitol. 50 (1990) 289-299
25. Hamilton C.M., Staffor P., Pinelli E., and Holland C.V. A murine model for cerebral toxocariasis: characterization of host susceptibility and behaviour. Parasitology 132 (2006) 791-801
26. Hayashi E., Akao N., and Fujita K. Evidence for the involvement of the optic nerve as a migration route for larvae in ocular toxocariasis of Mongolian gerbils. J. Helminthol. 77 (2003) 311-315
27. Holland C.V., and Cox D.M. Toxocara in the mouse: a model for parasite-altered host behaviour?. J. Helminthol. 75 (2001) 125-135
28. Kato N. Studies on experimental toxocariasis: resistance against challenge infection in infected or immunized mice and treatment with diethylcarbamazine of infected mice. Act. Sch. Med. Imover. Gifu. 21 (1973) 159-168
29. Kayes S. Human toxocariasis and visceral larva migrans syndrome: correlative immunopathology. Chem. Immunol. 66 (1997) 99-124
30. Kayes S.G., Omholt P.E., and Grieve R.B. Immune responses of CBA/J mice to graded infections with Toxocara canis. Infect. Immun. 48 (1985) 697-703
31. Kazacos K.R. Visceral and ocular larva migrans. Semin. Vet. Med. Surg. (Small Anim.) 6 (1991) 227-235
32. Kondo K., Kurimolo H., Orla K., Shimada Y., Tanako N., Fujisana K., and Otaka K. Experimental studies on "larva migrans". I. Transition of blood picture in mice infected with Toxocara canis larvae. Jpn. J. Parasitol. 24 (1975) 137-143
33. Lee H. Effects of superinfection on the behavior of Toxocara canis larvae in mice. J. Parasitol. 46 (1960) 583-588
34. Logar J., Kraut A., and Likar M. Toxocara antibodies in patients with visceral or ocular disorder in Slovenia. Infection 21 (1993) 27-29
35. Magnaval J.F., Glickman L.T., Dorchies P., and Morassin B. Highlights of human toxocariasis. Korean J. Parasitol. 39 (2001) 1-11
36. Maruyama S., Yamamoto K., and Katsube Y.Y. Infectivity of Toxocara canis larvae from Japanese quails in mice. J. Vet. Med. Sci. 56 (1994) 399-401
37. Olson L.J. Ocular toxocariasis in mice: distribution of larvae and lesions. Int. J. Parasitol. 6 (1976) 247-251
38. Overgaauw P.A.M. Aspects of Toxocara epidemiology: human toxocarosis. Crit. Rev. Microbiol. 23 (1997) 215-231
39. Parsons J.C., and Grieve R.B. Effect of egg dosage and host genotype on liver trapping in murine larval toxocariasis. J. Parasitol. 76 (1990) 53-58
40. Pollard Z.F., Jarrett W.H., Allain D.S., and Schantz P.M. ELISA for diagnosis of ocular toxocariasis. Ophthalmology 86 (1979) 743
41. Prokopic J., and Figallova V. Migration of some roundworm species in experimentally infected white mice. Folia Parasitol. 29 (1982) 309-313
42. Schantz P.M. Toxocara larva migrans now. Am. J. Trop. Med. Hyg. 41 (1989) S-21-34
43. Sugane K., and Oshima T. Trapping of large numbers of larvae in the livers of Toxocara canis reinfected mice. J. Helminthol. 57 (1983) 95-99
44. Takayanagi T.H., Akao N., Suzuki R., Tomoda M., Tsukidate S., and Fujita K. New animal model for human ocular toxocariasis: ophthalmoscopic observation. Br. J. Ophtalmol. 83 (1999) 967-972
45. Watzke M.D., Oaks J.A., and Folk J.C. Toxocara canis infection of the eye: correlation of clinical observations with developing pathology in the primate model. Arch. Ophtalmol. l02 (1984) 282-291