Topical 0.5% moxifloxacin prevents endophthalmitis in an intravitreal injection rabbit model

Journal of Ocular Pharmacology and Therapeutics

Volumn 24, Issue 1, 2008, Pages 1-7

  Kowalski, Regis P ^a,b   Romanowski, Eric G ^a   Mah, Francis S ^a   Yates, Kathleen A ^a   Gordon, Y Jerold ^a  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^b University of Pittsburgh School of Medicine   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MOXIFLOXACIN; SODIUM CHLORIDE; TRIAMCINOLONE;

ANIMAL EUTHANASIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBIOTIC THERAPY; ARTICLE; BACTERIAL VIABILITY; BACTERIUM CULTURE; CONJUNCTIVA; CONTROLLED STUDY; DISEASE COURSE; ENDOPHTHALMITIS; NONHUMAN; PROPHYLAXIS; RABBIT; STAPHYLOCOCCUS AUREUS; VITREOUS BODY;

ADMINISTRATION, TOPICAL; ANIMALS; ANTI-INFECTIVE AGENTS; AZA COMPOUNDS; CONJUNCTIVITIS; ENDOPHTHALMITIS; INJECTIONS; OPHTHALMIC SOLUTIONS; QUINOLINES; RABBITS; STAPHYLOCOCCAL INFECTIONS; VITREOUS BODY;

EID: 38549181521     PISSN: 10807683     EISSN: None     Source Type: Journal    
DOI: 10.1089/jop.2007.0071     Document Type: Article

References (8)

1. Speaker, M.G., and Menikoff, J.A. Prophylaxis of endophthalmitis with topical povidone-iodine. Ophthalmology 98:1769-1777, 1991.
2. Kimm D.H., Stark, W.J., O'Brien, T.P., et al. Aqueous penetration and biological activity of moxifloxacin 0.5% ophthalmic solution and gatifloxacin 0.3% solution in cataract surgery patients. Ophthalmology 112:1992-1996, 2005.
3. Solomon, R., Donnenfeld, E.D., Perry, H.D., et al. Penetration of topically applied gatifloxacin 0.3%, moxifloxacin 0.5%, and ciprofloxacin 0.3% into the aqueous humor. Ophthalmology 112:466-469, 2005.
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6. Kowalski, R.P., Romanowski, E.G., Mah, F.S., et al. Topical prophylaxis with moxifloxacin prevents endophthalmitis in a rabbit model. Am. J. Ophthalmol. 138:33-37, 2004.
7. Kowalski, R.P., Romanowski, E.G., Mah, F.S., et al. Intracameral Vigamox (0.5% moxifloxacin) is nontoxic and effective in preventing endophthalmitis in a rabbit model. Am. J. Ophthal. 140:497-504, 2005.
8. Costello, P., Bakri, S.J., Beer, P.M., et al. Vitreous penetration of topical moxifloxacin and gatifloxacin in humans. Retina 26:191-195, 2006.