Metabolic fluxes in the liver of rats bearing the Walker-256 tumour: Influence of the circulating levels of substrates and fatty acids

Cell Biochemistry and Function

Volumn 26, Issue 1, 2008, Pages 51-63

  Da Veiga, Renata P ^a   Da Silva, Mário H R Alves ^a   Teodoro, Graziele R ^a   Yamamoto, Nair Seiko ^a   Constantin, Jorgete ^a   Bracht, Adelar ^a,b  

^a STATE UNIVERSITY OF MARINGÁ   (Brazil)

^b Department of Biochemistry   (Brazil)

Author keywords

Fatty acid concentrations; Gluconeogenesis; Physiologic substrate concentrations; Ureogenesis; Walker 256 tumour

Indexed keywords

ALANINE; FATTY ACID; LACTIC ACID; NICOTINAMIDE ADENINE DINUCLEOTIDE; OLEIC ACID; PYRUVIC ACID; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE;

AMMONIA FORMATION; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; ENZYME SUBSTRATE; FATTY ACID BLOOD LEVEL; GLUCONEOGENESIS; KETOGENESIS; LIVER METABOLISM; LIVER PERFUSION; MALE; METABOLIC RATE; NONHUMAN; OXYGEN CONSUMPTION; PARAMETER; PRIORITY JOURNAL; RAT; UREA CYCLE; WALKER CARCINOMA;

ANIMALS; CARCINOMA 256, WALKER; FATTY ACIDS; GLUCONEOGENESIS; LACTIC ACID; LIVER; LIVER NEOPLASMS, EXPERIMENTAL; MALE; OLEIC ACID; RATS; RATS, WISTAR;

RATTUS;

EID: 38549160796     PISSN: 02636484     EISSN: 10990844     Source Type: Journal    
DOI: 10.1002/cbf.1398     Document Type: Article

References (34)

1. Seelaender MC, Curi R, Colquhoun A, Williams JF, Zammit VA. Carnitine palmitoyltransferase II activity is decreased in liver mitochondria of cachectic rats bearing the Walker-256 carcinosarcoma: effect of indomethacin treatment. Biochem Mol Biol Int 1998; 44: 185-193.
2. Vicentino C, Constantin J, Bracht A, Yamamoto NS. Long-chain fatty acid uptake and oxidation in the perfused liver of Walker-256 tumour-bearing rats. Liver 2002; 22: 341-350.
3. Vicentino C, Constantin J, Stecanella L, Bracht A, Yamamoto NS. Glucose and glycogen catabolism in perfused livers of Walker-256 tumor-bearing rats and the response to hormones. Pathophysiology 2002; 8: 175-182.
4. Williams JF, Siddiqui RA. Biochemistry of cancer cachexia: review of results, a new hypothesis and a proposal for treatment. Med Sci Res 1990; 18: 3-10.
5. Corbello-Pereira SR, Darronqui E, Constantin J, Silva MHRA, Yamamoto NS, Bracht A. The urea cycle and related pathways in the liver of Walker-256 tumor-bearing rats. Biochim Biophys Acta 2004; 1688: 187-196.
6. Shearer J, Caldwell M, Crosby LO, Miller E, Buzby GP, Mullen JL. Tumor effects on gluconeogenesis in the isolated perfused rat liver. J Parent Ent Nutr 1983; 7: 105-109.
7. Shearer JD, Buzby GP, Mullen JL, Miller E, Caldwell MD. Alteration in pyruvate metabolism in the liver of tumor-bearing rats. Cancer Res 1984; 44: 4443-4446.
8. Blumberg D, Burt ME, Kher U, Brennan MF. Tolbutamide inhibits gluconeogenesis in the tumor-influenced hepatocyte. J Surg Res 1993; 55: 565-569.
9. Fischer CP, Bode BP, Hurley BP, Souba WW. Alterations in oxidative metabolism and glutamine transport support glucose production in the tumor-influenced hepatocyte. J Surg Res 1997; 69: 379-384.
10. Liu KJ, Henderson T, Kieps RA, Reyes MC, Nyhus L. Gluconeogenesis in the liver of tumor rats. J Surg Res 1990; 49: 179-185.
11. Argilés JM, López-Soriano FJ. The energy state of tumor-bearing rats. J Biol Chem 1991; 266: 2978-2982.
12. Pinto-Jr JA, Folador A, Bonato SJ, et al. Fish oil supplementation in F1 generation associated with naproxen, clenbuterol, and insulin administration reduce tumor growth and cachexia in Walker 256 tumor-bearing rats. J Nutr Biochem 2004; 15: 358-365.
13. Tisdale MJ. Metabolic abnormalities in cachexia and anorexia. Nutrition 2000; 16: 1013-1014.
14. Williamson JR, Kreisberg RA, Felts PW. Mechanism for the stimulation of gluconeogenesis by fatty acids in perfused rat liver. Proc Nat Acad Sci USA 1966; 56: 247-254.
15. Williamson JR, Browning ET, Scholz R. Control mechanisms of gluconeogenesis and ketogenesis. I. Effects of oleate on gluconeogenesis in perfused rat liver. J Biol Chem 1969; 244: 4607-4616.
16. Johnson MEM, Das NM, Butcher FR, Fain JN. The regulation of gluconeogenesis in isolated rat liver cells by glucagon, insulin, dibutyryl cyclic adenosine monophosphate, and fatty acids. J Biol Chem 1972; 247: 3229-3235.
17. Groen AK, Vervoorn RC, Van der Meer R, Tager JM. Control of gluconeogenesis in rat liver cells. I. Kinetics of the individual enzymes and the effect of glucagon. J Biol Chem 1983; 258: 14346-14353.
18. Patel TB, Barron LL, Olson MS. The stimulation of hepatic gluconeogenesis by acetoacetate precursors. A role for the monocarboxylate translocator. J Biol Chem 1984; 259: 7525-7531.
19. Scholz R, Bücher T. Hemoglobin-free perfusion of rat liver. In Control of Energy Metabolism, Chance B, Estabrook RW, Williamson JR (eds). Academic Press: New York, 1965; 393-414.
20. Bergmeyer HU, Bernt E. Determination of glucose with glucose oxidase and peroxidase. In Methods of Enzymatic Analysis, Bergmeyer HU (ed.). Verlag Chemie-Academic Press: Weinheim-London, 1974; 1205-1215.
21. Gutmann J, Bergmeyer HU. Determination of urea with glutamate dehydrogenase as indicator enzyme. In Methods of Enzymatic Analysis, Bergmeyer HU (ed.). Verlag Chemie-Academic Press: Weinheim-London, 1974; 1794-1798.
22. Kun E, Kearney EB. Ammonia. In Methods of Enzymatic Analysis, Bergmeyer HU (ed.). Verelag Chemie-Academic Press: Weinheim-London, 1974; 1802-1806.
23. Williamson DH, Mellanby J. D-(-)-3-Hydroxybutyrate. In Methods of Enzymatic Analysis, Bergmeyer HU (ed.). Verlag Chemie-Academic Press: Weinheim-London, 1974; 1836-1839.
24. Mellanby J, Williamson DH. Acetoacetate. In Methods of Enzymatic Analysis, Bergmeyer HU (ed.). Verlag Chemie-Academic Press: Weinheim-London, 1974; 1840-1843.
25. 2 production following addition of octanoate and oleate in perfused rat liver. Eur J Biochem 1984; 141: 223-230.
26. Sies H. Nicotinamide nucleotide compartmentation. In Metabolic Compartmentation, Sies H (ed.). Academic Press: New York, 1982; 205-231.
27. Baker N, Schotz MC. Quantitative aspects of free fatty acid metabolism in the fasted rat. J Lipid Res 1967; 8: 646-660.
28. Baker N, Rostami H. Effect of glucose feeding on net transport of plasma free fatty acids. J Lipid Res 1969; 10: 83-90.
29. Siess EA, Brocks DG, Wieland OH. Subcellular distribution of adenine nucleotides and of metabolites of tricarboxylate cycle and gluconeogenesis in hepatocytes. In Metabolic Compartmentation, Sies H (ed.). Academic Press: New York, 1982; 235-257.
30. Scholz R, Olson MS, Schwab AJ, Schwabe U, Noell C, Braun W. The effect of fatty acids on the regulation of pyruvate dehydrogenase in perfused rat liver. Eur J Biochem 1978; 86: 519-530.
31. Batenburg JJ, Olson MS. Regulation of pyruvate dehydrogenase by fatty acid in isolated rat liver mitochondria. J Biol Chem 1976; 251: 1364-1370.
32. Papa S, Paradies G. On the mechanism of translocation of pyruvate and other monocarboxylic acids in rat liver mitochondria. Eur J Biochem 1974; 49: 265-274.
33. 35 lipoic acid distribution and its effect on pyruvate dehydrogenase activity in rats with Walker carcinoma. Vopr Onkol 1977; 23: 87-90.
34. Nemeria NS, Trevukhina RV. Activity of the pyruvate dehydrogenase complex in Walker-256 carcinosarcoma. Ukr Biokhim Zh 1993; 65: 28-33.