Masked clozapine-induced cardiomyopathy

Journal of the American Board of Family Medicine

Volumn 21, Issue 1, 2008, Pages 70-74

  Pastor, Charles A ^a   Mehta, Monica ^b  

^a BRONX LEBANON HOSPITAL CENTER   (United States)

^b LONG ISLAND UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CLONAZEPAM; CLOZAPINE; ENALAPRIL; LITHIUM; LORAZEPAM; METOPROLOL TARTRATE; OLANZAPINE; VALPROATE SEMISODIUM;

ADULT; ARTICLE; CARDIOMYOPATHY; CASE REPORT; DRUG DOSE REDUCTION; DRUG DOSE TITRATION; DRUG SUBSTITUTION; DRUG WITHDRAWAL; EVENING DOSAGE; FEMALE; FEVER; HEART FAILURE; HEART FUNCTION; HEART LEFT VENTRICLE EJECTION FRACTION; HUMAN; MOOD DISORDER; MORNING DOSAGE; PSYCHOSIS; RISK FACTOR; TACHYCARDIA; TREMOR;

ADULT; ANTIPSYCHOTIC AGENTS; BENZODIAZEPINES; CARDIOMYOPATHIES; CLOZAPINE; DIAGNOSIS, DIFFERENTIAL; DRUG ADMINISTRATION SCHEDULE; FEMALE; HUMANS; SCHIZOPHRENIA;

EID: 38549145941     PISSN: 15572625     EISSN: 15587118     Source Type: Journal    
DOI: 10.3122/jabfm.2008.01.070091     Document Type: Article

References (19)

1. Merrill DB, Dec W, Goff D. Adverse cardiac effects associated with clozapine. J Clin Psychopharmacol 2005;25:32-41.
2. Physicians' desk reference, 59th ed. Stamford (CT): Thompson PDR; 2005.
3. Committee on Safety of Medicines. Myocarditis with antipsychotics: recent cases with clozapine (Clozaril). Current Problems in Pharmacovigilance 1993;19:9-10.
4. Kilian J, Kerr K, Lawrence C, Celermajer D. Myocarditis and cardiomyopathy associated with clozapine. Lancet 1999;354:1841-5.
5. Novartis. Clozaril (clozapine tablets). Prescribing information. Available at http://www.novartis.ca/downloads/en/products/clozarilscripe.pdf. Accessed 20 February 2007.
6. Leo R, Kreeger J, Kim K. Cardiomyopathy associated with clozapine. Ann Pharmacother 1996;30:603-5.
7. Tanner M, Culling W. Clozapine-associated dilated cardiomyopathy. Postgrad Med J 2003;79:412-3.
8. Roh S, Ahn D, Nam J, Yang B, Lee B, Kim Y. Cardiomyopathy associated with clozapine. Exp Clin Psychopharmacol 2006;14:94-8.
9. De Boni R, Gama CS, Lobato MI. [Mocardial disease in a patient treated with clozapine.] Rev Bras Psiquiatr 2005;27:164.
10. Worrel J, Marken P, Beckman S, et al. Atypical antipsychotic agents. Am J Health Syst Pharm 2000;57:238-58.
11. Sungwon R, Dong H, Jung H, Byung H, Bang H, Yang S. Cardiomyopathy associated with clozapine. Exp Clin Psychopharmacol 2006;14:94-8.
12. Conley RR. Optimizing treatment with clozapine. J Clin Psychiatry 1998;59:44-8.
13. Walker AM, Lanza LL, Arellano F, et al. Mortality in current and former users of clozapine. Epidemiology 1997;8:671-7.
14. Green A, Burgess E. Use in schizophrenia: effects of clozapine vs. risperidone. Schizophr Res 2003;60:81-5.
15. Coulter D, Bate A, Meyboom R, et al. Antipsychotic drugs and heart muscle disorder in international pharmacovigilance: data mining study. BMJ 2001;322:1207-9.
16. Berger A, Medline Plus. (2006) Cardiomyopathy. Available at http://www.nlm.nih.gov/medlineplus/ency/article/001105.htm. Accessed 20 February 2007.
17. Wehmeier P, Heiser P, Remschimidt H. Myocarditis, pericarditis and cardiomyopathy in patients treated with clozapine. J Clin Pharm Ther 2005;30:91-6.
18. Devarajan S, Kutcher SP, Dursun SM. Clozapine and sudden death [Letter]. Lancet 2000;355:841.
19. Vaddadi K, Soosai E, Vaddadi G. Low blood selenium concentrations in schizophrenic patients on clozapine. Br J Clin Pharmacol 2003;55:307-9.