Malignant insulinoma presenting as metastatic liver tumor. Case report and review of the literature

Journal of Experimental and Clinical Cancer Research

Volumn 26, Issue 4, 2007, Pages 603-607

  Baldelli, R ^a   Ettorre, G ^a   Vennarecci, G ^a   Pasimeni, G ^a   Carboni, F ^a   Lorusso, R ^a   Barnabei, A ^a   Appetecchia, Marialuisa ^a  

^a REGINA ELENA NATIONAL CANCER INSTITUTE   (Italy)

Author keywords

Malignant insulinoma; Octreotide; Somatostatin analog

Indexed keywords

DIAZOXIDE; GLUCOSE; INSULIN; OCTREOTIDE; PENTETREOTIDE IN 111;

AGED; ANXIETY; ARTICLE; BEHAVIOR CHANGE; BLOOD EXAMINATION; BLURRED VISION; CANCER SURGERY; CASE REPORT; CLINICAL FEATURE; COMPUTER ASSISTED TOMOGRAPHY; CONFUSION; DIABETES MELLITUS; DIZZINESS; FEMALE; GLUCOSE BLOOD LEVEL; HUMAN; HYPERINSULINEMIA; HYPERTENSION; HYPOGLYCEMIA; HYPOTHYROIDISM; IMMUNOHISTOCHEMISTRY; INSULIN BLOOD LEVEL; INSULINOMA; LIVER BIOPSY; LIVER METASTASIS; NEUROENDOCRINE TUMOR; PANCREAS; PERSONALITY DISORDER; PHYSICAL EXAMINATION; PRIORITY JOURNAL; SYNCOPE; WEIGHT GAIN; WHOLE BODY SCINTISCANNING;

AGED; FEMALE; HUMANS; INSULINOMA; LIVER; LIVER NEOPLASMS; PANCREATIC NEOPLASMS;

EID: 38549144210     PISSN: 03929078     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (30)

1. Service F.J., McMahon M.M., O'Brien P.C. et al.: Functioning insulinoma: incidence, recurrence, and long-term survival of patients: a 60-year study. Mayo Clin. Proc. 66: 711-719, 1991.
2. Lack E.E.: Pancreatic endocrine neoplasms. In: Lack EE, ed. Pathology of the pancreas, gallbladder, extrahepatic biliary tract and ampullary region. New York: Oxford University Press; 323-373, 2003.
3. Grant C.S.: Surgical aspects of hyperinsulinemic hypoglycemia. Endocrinol. Metab. Clin. North Am. 28: 533-554, 1999.
4. Boukhman M.P., Karam J.M., Shaver J. et al.: Localization of insulinomas. Arch. Surg. 134: 818-822, 1999.
5. Wayne J.D., Tanaka R., Kaplan E.L.: Insulinomas. In: Clark OH, Duh QY, eds. Textbook of endocrine surgery. Philadelphia: Saunders; 577-591, 1997.
6. Kataoka H., Otsuka F., Yamauchi T. et al.: Giant insulinoma in a patient with multiple endocrine neoplasia type I: a case report. Endocr. J. 46: 429-435, 1999.
7. Vezzosi D., Bennet A., Fauvel J. et al.: Insulin levels measured with an insulin-specific assay in patients with fasting hypo-glycaemia related to endogenous hyperinsulinism. Eur. J. Endocrinol. 149: 413-419, 2003.
8. Pasieka J.L., McLeod M.K., Thompson N.W., Burney R.E.: Surgical approach to insulinomas: assessing the need for preoperative localization. Arch. Surg. 127:442-447, 1992.
9. Liu T.H., Tseng H.C., Zhu Y. et al.: Insulinoma: an immunocytochemical and morphologic analysis of 95 cases. Cancer 56: 1420-1429, 1985.
10. Doherty G.M., Doppman J.L., Shawker T.H. et al.: Results of a prospective strategy to diagnose, localize, and resect insulinomas. Surgery 110: 989-997, 1991.
11. Thompson N.W., Czako P.F., Fritts L.L. et al.: Role of endoscopic ultrasonography in the localization of insulinomas nd gastrinomas. Surgery 116: 1131-1138, 1994.
12. Danforth D.N., Gorden P., Brennan M.F. et al.: Metastatic insulin-secreting carcinoma of the pancreas: clinical course and the role of surgery. Surgery 96: 1027-1036, 1984.
13. Arensman R.M., Glassfor G.H. Giant insulinoma. Am. J. Surg. 131: 603-604, 1976.
14. Williams A.J., Coates P.J., Lowe D.G. et al.: Immunochemical investigations of insulinomas for islet amyloid polypeptide and insulin: evidence of differential synthesis and storage. Histopathology 21: 215-223, 1992.
15. Mukai K., Grotting J.C., Greider M.H. et al.: Retrospective study of 77 pancreatic endocrine tumors using the immunoperoxidase method. Am. J. Surg. Pathol. 6:387-399, 1982.
16. Que F.G., Nagorney D.M., Batts K.P. et al.: Hepaticresection for metastatic neuroendocrine carcinomas. Am. J. Surg. 169: 36-43, 1995.
17. Rindi G., Capella C., Solcia E. Introduction to a revised clinicopathological classification of neuroendocrine tumors of the gastroenteropancreatic tract. Q. J. Nucl. Med. 44: 13-21, 2000.
18. O'Brien T.D., Butler A.E., Johnson K.H. et al.: Islet amyloid polypeptide in human insulinomas. Evidence for intracellular amyloidogenesis. Diabetes 3: 329-336, 1994.
19. van Hulst K.L., Oosterwijk C., Born W. et al.: Islet amyloid polypeptide/amylin messenger RNA and protein expression in human insulinomas in relation to amyloid formation. Eur. J. Endocrinol. 140: 69-78, 1999.
20. Lam K., Lo C., Wat M. et al.: Malignant insulinoma with hepatoid differentiation: a unique case with alpha-fetoprotein production. Endocr. Pathol. 12: 351-354, 2001.
21. Shimoike T., Goto M., Nakano I., et al. Acinar-islet cell carcinoma presenting as insulinoma. J. Gastroenterol. 32: 830-835, 1997.
22. Graeme-Cook F., Nardi G., Compton C.C. Immunocytochemical staining for human chorionic gonadotropin subunits does not predict malignancy in insulinomas. Am. J. Clin. Pathol. 93:273-276, 1990.
23. Hirshberg B., Cochran C., Skarulis M.C. et al.: Malignant insulinoma: spectrum of unusual clinical features. Cancer. 104:264-72, 2005.
24. Vezzosi D., Bennet A., Rochaix P. et al.: Octreotide in insulinoma patients: efficacy on hypoglycemia, relationships with Octreoscan scintigraphy and immunostaining with anti-sst2A and anti-sst5 antibodies. Eur. J. Endocrinol. 152 :757-67, 2005.
25. Verschoor L., Uitterlinden P., Lamberts S.W. et al.: On the use of a new somatostatin analogue in the treatment of hypoglycaemia in patients with insulinoma. Clinical Endocrinology 25: 555-560, 1986.
26. Von Eyben F., Grodum E., Gjessing H. et al.: Metabolic remission with octreotide in patients with insulinoma. Journal of Internal Medicine 235: 245-248, 1994.
27. Kvols L., Buck M., Moertel C. et al.: Treatment of metastatic islet cell carcinoma with a somatostatin analogue (SMS 201-995). Annals of Internal Medicine 107: 162-168, 1987.
28. Starke A., Saddig C., Mansfeld L. et al.: Malignant metastatic insulinoma-postoperative treatment and follow-up. World J. Surg. 29: 789-73, 2005.
29. House M.G., Cameron J.L., Lillemoe K.D. et al.: Differences in survival for patients with resectable versus unresectable metastases from pancreatic islet cell cancer. J. Gastrointest. Surg. 10: 138-145, 2006.
30. Sarmiento J.M., Que F.G., Grant C.S. et al.: Concurrent resections of pancreatic islet cell cancers with synchronous hepatic metastases: outcomes of an aggressive approach. Surgery 132: 976-982, 2002.