Antiepileptic drugs and brain maturation: Fetal exposure to lamotrigine generates cortical malformations in rats

Epilepsy Research

Volumn 78, Issue 2-3, 2008, Pages 131-139

  Manent, Jean Bernard ^a,b   Jorquera, Isabel ^a,b   Franco, Valentina ^c   Ben Ari, Yehezkel ^a,b   Perucca, Emilio ^c,d   Represa, Alfonso ^a,b  

^a Turing Center for Living Systems CENTURI Aix Marseille University   (France)

^b AIX MARSEILLE UNIVERSITY   (France)

^c UNIVERSITY OF PAVIA   (Italy)

^d C MONDINO NATIONAL NEUROLOGICAL INSTITUTE   (Italy)

Author keywords

Antiepileptic drugs; Cortical malformations; Fetal development; Lamotrigine; Rats

Indexed keywords

ETIRACETAM; LAMOTRIGINE; PHENOBARBITAL; TOPIRAMATE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; BRAIN DEVELOPMENT; BRAIN MALFORMATION; BRAIN MATURATION; CONTROLLED STUDY; CORRELATION ANALYSIS; CORTICAL DYSPLASIA; DOSE RESPONSE; DRUG BLOOD LEVEL; EMBRYO; FEMALE; FETUS MALFORMATION; GABAERGIC SYSTEM; HIPPOCAMPUS; MATERNAL PLASMA; NONHUMAN; PRENATAL DRUG EXPOSURE; PRIORITY JOURNAL; RAT; TERATOGENICITY;

ANIMALS; ANTICONVULSANTS; BRAIN; CELL COUNT; CELL MOVEMENT; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; FRUCTOSE; HIPPOCAMPUS; IMMUNOHISTOCHEMISTRY; LITTER SIZE; MALFORMATIONS OF CORTICAL DEVELOPMENT; NEURONS; PHENOBARBITAL; PIRACETAM; PREGNANCY; RATS; RATS, WISTAR; TERATOGENS; TRIAZINES; WEIGHT GAIN;

EID: 38549100026     PISSN: 09201211     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.eplepsyres.2007.10.014     Document Type: Article

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