CYP2D6 genotyping and codeine [5]

Paediatric Anaesthesia

Volumn 18, Issue 3, 2008, Pages 274-275

  Leon, Jose De ^a  

^a Eastern State Hospital   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CODEINE; CYTOCHROME P450 2D6; HYDROCODONE; MORPHINE; OXYCODONE;

AFRICAN AMERICAN; ALLELE; APNEA; CAUCASIAN; CHROMOSOME; COMA; DNA POLYMORPHISM; ENZYME ACTIVITY; GENE DUPLICATION; GENOTYPE; HUMAN; INTOXICATION; KIDNEY DYSFUNCTION; KIDNEY FUNCTION; LETTER; MENTAL DISEASE; PHENOTYPE; PRIORITY JOURNAL; PUBLICATION; UNITED STATES;

ALLELES; APNEA; CHILD; CODEINE; CYTOCHROME P-450 CYP2D6; HUMANS; NARCOTICS; PHENOTYPE; POLYMORPHISM, GENETIC;

EID: 38549096032     PISSN: 11555645     EISSN: 14609592     Source Type: Journal    
DOI: 10.1111/j.1460-9592.2008.02420.x     Document Type: Letter

References (5)

1. Voronov P, Przybylo HJ, Jagannathan N. Apnea in a child after oral codeine: a genetic variant - an ultra-rapid metabolizer. Paediatr Anaesth 2007 17 : 684 687.
2. de Leon J. The AmpliChip CYP450 test: personalized medicine has arrived in psychiatry. Expert Rev Mol Diagn 2006 6 : 277 286.
3. Dalen P, Frengell C, Dahl ML et al. Quick onset of severe abdominal pain after codeine in an ultrarapid metabolizer of debrisoquine. Ther Drug Monit 1997 19 : 543 544.
4. de Leon J, Dinsmore L, Wedlund PJ. Adverse drug reactions to oxycodone and hydrocodone in CYP2D6 ultrarapid metabolizers (letter). J Clin Psychopharmacol 2003 23 : 420 421.
5. Gasche Y, Daali Y, Fathi M et al. Codeine intoxication associated with ultrarapid CYP2D6 metabolism. N Eng J Med 2004 351 : 2827 2831.