Effect of retinol palmitate eye drops on experimental keratoconjunctival epithelial damage induced by n-heptanol in rabbit

Current Eye Research

Volumn 33, Issue 1, 2008, Pages 13-18

  Toshida, Hiroshi ^a   Odaka, Akito ^a,b   Koike, Daisuke ^b   Murakami, Akira ^a  

^a JUNTENDO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b LION CORPORATION   (Japan)

Author keywords

Dry eye; Goblet cell; Mucin; Vitamin A; Wound healing

Indexed keywords

EYE DROPS; FLUORESCEIN; HEPTANOL; RETINOL PALMITATE; ROSE BENGAL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONJUNCTIVA EPITHELIUM; CONTROLLED STUDY; DRUG EFFICACY; EYE INJURY; HISTOLOGY; KERATOCONJUNCTIVAL INJURY; MALE; NONHUMAN; PRIORITY JOURNAL; RABBIT; STAINING; WOUND HEALING;

ANIMALS; BURNS, CHEMICAL; CONJUNCTIVAL DISEASES; CORNEAL DISEASES; DISEASE MODELS, ANIMAL; EPITHELIAL CELLS; EYE BURNS; EYE PROTEINS; FLUORESCEIN; FLUORESCENT DYES; HEPTANOL; MALE; MUCINS; OPHTHALMIC SOLUTIONS; RABBITS; ROSE BENGAL; TEARS; VITAMIN A; WOUND HEALING;

EID: 38549090985     PISSN: 02713683     EISSN: 14602202     Source Type: Journal    
DOI: 10.1080/02713680701827696     Document Type: Article

References (20)

1. Ubels JL, MacRae SM. Vitamin A is present as retinol in the tears of humans and rabbits. Curr Eye Res. 1984;3:815-822.
2. Kubo Y, Arimura A, Watanabe Y, Nakayasu K, Kanai A. Effect of vitamin A palmitate on vitamin A-deficient rabbits. J Jpn Ophthalmol Soc. 1999;103:729-733.
3. Ubels JL, Edelhauser HF, Foley KM, Liao JC, Gressel P. The efficacy of retinoic acid ointment for treatment of xerophthalmia and corneal epithelial wounds. Curr Eye Res. 1985;4:1049-1057.
4. Kubo Y, Arimura A, Nakayasu K, Kanai A. Effect of vitamin A palmitate on the synthesis of mucins in cultured conjuntiva. J Jpn Ophthalmol Soc. 1999;103:580-583.
5. Hori Y, Spurr-Michaud SJ, Russo CL, Argüeso P, Gipson IK. Effect of retinoic acid on gene expression in human conjunctival epithelium: Secretory phospholipase A2 mediates retinoic acid induction of MUC16. Invest Ophthalmol Vis Sci. 2005;46:4050-4061.
6. Wright P. 1985. Topical retinoic acid therapy for disorders of the outer eye. Trans Ophthalmol Soc UK. 1985;104:869-874.
7. Soong HK, Martin NF, Wagoner MD, Alfonso E, Mandelbaum SH, Laibson PR, Smith RE, Udell I. 1988. Topical retinoid therapy for squamous metaplasia of various ocular surface disorders. A multicenter, placebo-controlled double-masked study. Ophthalmology. 1988;95:1142-1146.
8. Ohashi Y, Watanabe H, Kinoshita S, Hosotani H, Umemoto M, Manabe R. Vitamin A eyedrops for superior limbic keratoconjunctivitis. Am J Ophthalmol. 1988;105:523-527.
9. Kobayashi T, Tsubota K, Takamura E, Sawa M, Ohashi Y, Usui M. Effect of retinol palmitate as a treatment for dry eye: A cytological evaluation. Ophthalmologica. 1997;211:358-361.
10. Kessing SV. Mucous gland system of the conjunctiva. A quantitative normal anatomical study. Acta Ophthalmol Suppl. 1968;95:1.
11. Watanabe H, Fabricant M, Tisdale AS, Spurr-Michaud SJ, Lindberg K, Gipson IK. Human corneal and conjunctival epithelia produce a mucin-like glycoprotein for the apical surface. Invest Ophthalmol Vis Sci. 1995;36:337-344.
12. Johansen S, Heegaard S, Prause JU, Rask-Pedersen E. The healing effect of all-trans retinoic acid on epithelial corneal abrasions in rabbits. Acta Ophthalmol Scand. 1998;76:401-404.
13. Araki K, Ohashi Y, Kinoshita S, Hayashi K, Kuwayama Y, Tano Y. Epithelial wound healing in the denervated cornea. Curr Eye Res. 1993;13:203-211.
14. Ohashi Y, Watanabe TM, Umemoto M, Kinoshita YH, Kinoshita S, Watanabe H, Manabe R. Effect of vitamin A instillation on corneal and conjuntival disorders. Rinsho Ganka (Jpn J Clin Ophthalmol). 1987;41:368-369.
15. Lemp MA. Report of the National Eye Institute/Industry workshop on clinical trials in dry eyes. CLAO J. 1995;21:221-232.
16. Van Bijsterveld, OP. Diagnostic tests in the sicca syndrome. Arch Ophthalmol. 1969;82:10-14.
17. Toshida H, Nakata K, Hamano T, Nakamura M, Nguyen D, Beuerman RW. Effect of gefarnate on the ocular surface in squirrel monkeys. Cornea. 2002;21:292-299.
18. Toshida H, Nakata K, Hamano T, Nakamura M, Nguyen D, Beuerman R. Gefarnate stimulates goblet cell repopulation following an experimental wound to the tarsal conjunctiva in the dry eye rabbit. Adv Exp Med Biol. 2002;506(Pt A):353-357.
19. 2 receptor elicits PAS-positive glycoprotein secretion from rabbit conjunctival goblet cells in vivo.J Ocul Pharmacol Ther. 2003;19:345-352.
20. Shigemitsu T, Shimizu Y, Majima Y. Effects of mucin ophthalmic solution on epithelial wound healing in rabbit cornea. Ophthalmic Res. 1997;29:61-66.