The mechanism of Axl-mediated ebola virus infection

Journal of Infectious Diseases

Volumn 196, Issue SUPPL. 2, 2007, Pages

  Shimojima, Masayuki ^a,b   Ikeda, Yasuhiro ^c   Kawaoka, Yoshihiro ^a,b,d  

^a UNIVERSITY OF TOKYO   (Japan)

^b JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

^c Mayo Clinic   (United States)

^d UNIVERSITY OF WISCONSIN MADISON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CATHEPSIN; PROTEIN AXL; TYROSINE KINASE RECEPTOR; UNCLASSIFIED DRUG; VIRUS GLYCOPROTEIN; AXL RECEPTOR TYROSINE KINASE; GLYCOPROTEIN; ONCOPROTEIN; PROTEIN TYROSINE KINASE; RECOMBINANT PROTEIN; VIRUS PROTEIN;

CONFERENCE PAPER; CONTROLLED STUDY; EBOLA VIRUS; ENDOCYTOSIS; GENE DELETION; GENE MUTATION; HUMAN; LIGAND BINDING; NONHUMAN; PH; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; VIRUS CELL INTERACTION; VIRUS INFECTION; ARTICLE; CELL LINE; GENETICS; KIDNEY; LEUKEMIA CELL LINE; METABOLISM; MUTAGENESIS; PATHOGENICITY; PHYSIOLOGY; PLASMID; POLYMERASE CHAIN REACTION;

CELL LINE; EBOLAVIRUS; GLYCOPROTEINS; HUMANS; JURKAT CELLS; KIDNEY; MUTAGENESIS; ONCOGENE PROTEINS; PLASMIDS; POLYMERASE CHAIN REACTION; RECEPTOR PROTEIN-TYROSINE KINASES; RECOMBINANT PROTEINS; VIRAL PROTEINS;

EID: 38449119465     PISSN: 00221899     EISSN: None     Source Type: Journal    
DOI: 10.1086/520594     Document Type: Conference Paper

References (15)

1. Feldmann H, Geisbert TW, Jahrling PB, et al. Family Filoviridae. In: Fauquet CM, Mayo MA, Maniloff J, Desselberger U, Ball LA, eds. Virus taxonomy. 8th ed. London: Elsevier/Academic Press, 2004:645-53.
2. Takada A, Robison C, Goto H, et al. A system for functional analysis of Ebola virus glycoprotein. Proc Natl Acad Sci USA 1997; 94:14764-9.
3. Wool-Lewis RJ, Bates P. Characterization of Ebola virus entry by using pseudotyped viruses: identification of receptor-deficient cell lines. J Virol 1998; 72:3155-60.
4. Simmons G, Reeves JD, Grogan CC, et al. DC-SIGN and DC-SIGNR bind Ebola glycoproteins and enhance infection of macrophages and endothelial cells. Virology 2003; 305:115-23.
5. Takada A, Fujioka K, Tsuiji M, et al. Human macrophage C-type lectin specific for galactose and N-acetylgalactosamine promotes filovirus entry. J Virol 2004; 78:2943-47.
6. Takada, A, Watanabe S, Ito H, Okazaki K, Kida H, Kawaoka Y. Down-regulation of β1 integrins by Ebola virus glycoprotein: implication for virus entry. Virology 2000; 278:20-6.
7. Shimojima M, Takada A, Ebihara H, et al. Tyro3 family-mediated cell entry of Ebola and Marburg viruses. J Virol 2006; 80:10109-16.
8. O'Bryan JP, Frye RA, Cogswell PC, et al. axl, a transforming gene isolated from primary human myeloid leukemia cells, encodes a novel receptor tyrosine kinase. Mol Cell Biol 1991; 11:5016-31.
9. Valverde P. Effects of Gas6 and hydrogen peroxide in Axl ubiquitination and down regulation. Biochem Biophys Res Comm 2005; 333:180-5.
10. Angelillo-Scherrer A, Burnier L, Flores N, et al. Role of Gas6 receptors in platelet signaling during thrombus stabilization and implications for antithrombotic therapy. J Clin Invest 2005; 115:237-46.
11. D'Arcangelo D, Ambrosino V, Giannuzzo M, Gaetano C, Capogrossi MC. Axl receptor activation mediates laminar shear stress anti-apoptotic effects in human endothelial cells. Cardiovasc Res 2006; 71:754-63.
12. Shimojima M, Nishimura Y, Miyazawa T, et al. A feline CD2 homologue interacts with human red blood cells. Immunology 2002; 105:360-6.
13. Sasaki T, Knyazev PG, Clout NJ, et al. Structural basis for Gas6-Axl signalling. EMBO J 2006; 25:80-7.
14. Braunger J, Schleithoff L, Schulz AS, et al. Intracellular signaling of the Ufo/Axl receptor tyrosine kinase is mediated mainly by a multisubstrate docking-site. Oncogene 1997; 14:2619-31.
15. Chandran K, Sullivan NJ, Felbor U, Whelan SP, Cunningham JM. Endosomal proteolysis of the Ebola virus glycoprotein is necessary for infection. Science 2005; 308:1643-5.