Experimental transmission of scrapie agent to susceptible sheep by intralingual or intracerebral inoculation

Canadian Journal of Veterinary Research

Volumn 72, Issue 1, 2008, Pages 63-67

  Hamir, Amir N ^a   Kunkle, Robert A ^a   Bulgin, Marie S ^b   Rohwer, Robert G ^c   Gregori, Luisa ^c   Richt, Juergen A ^a  

^a NATIONAL ANIMAL DISEASE CENTER   (United States)

^b UNIVERSITY OF IDAHO   (United States)

^c UNIVERSITY OF MARYLAND   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PRION PROTEIN;

ANIMAL EUTHANASIA; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN HEMATOMA; CENTRAL NERVOUS SYSTEM INFECTION; CODON; CONTROLLED STUDY; FEMALE; GENETIC SUSCEPTIBILITY; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; INFECTION SENSITIVITY; INOCULATION; INTERMETHOD COMPARISON; LAMB; MALE; NONHUMAN; SCRAPIE; SCRAPIE AGENT; SHEEP DISEASE; SURVIVAL TIME; VIRUS PATHOGENESIS; VIRUS TRANSMISSION; WESTERN BLOTTING;

ADMINISTRATION, ORAL; ANIMALS; BRAIN; FEMALE; GENETIC PREDISPOSITION TO DISEASE; INJECTIONS; MALE; PRPSC PROTEINS; SCRAPIE; SHEEP; SURVIVAL ANALYSIS; TONGUE;

ANIMALIA; CAPRA HIRCUS; OVIS ARIES;

EID: 38449106881     PISSN: 08309000     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (10)

1. Detwiler LA. Scrapie. Rev Sci Tech Off Int Epizoot 1992;11: 491-537.
2. Hamir AN, Kunkle RA, Richt JA, et al. Experimental transmission of sheep scrapie by intracerebral and oral routes to genetically susceptible Suffolk sheep in the United States. J Vet Diagn Invest 2005;17:3-9.
3. Bulgin MS, Sorensen SJ, Matlock ME. Association between incubation time and genotype in sheep experimentally inoculated with scrapie-positive brain homogenate. Am J Vet Res 2006;67:498-504.
4. Hamir AN, Miller JM, Stack MJ, et al. Failure to detect abnormal prion protein and scrapie-associated fibrils 6 wk affer intracerebral inoculation of genetically susceptible sheep with scrapie agent. Can J Vet Res 2002;66:289-294.
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8. Mulcahy ER, Bartz JC, Kincaid AE, et al. Prion infection of skeletal muscle cells and papillae in the tongue. J Virol 2004;78: 6792-6798.
9. Casalone C, Zanusso G, Acutis P, et al. Identification of a second bovine amyloidotic spongiform encephalopathy: molecular similarities with sporadic Creutzfeldt-Jakob disease. Proc Natl Acad Sci U S A 2004;101:3065-3070.
10. Bartz JC, Kincaid AE, Bessen RA. Rapid prion neuroinvasion following tongue infection. J Virol 2003;77:583-591.