Moraxella catarrhalis induces ERK- and NF-κB-dependent COX-2 and prostaglandin E2 in lung epithelium

European Respiratory Journal

Volumn 30, Issue 3, 2007, Pages 443-451

  N'Guessan, P D ^a   Temmesfeld Wollbruck B ^a   Zahlten, J ^a   Eitel, J ^a   Zabel, S ^a   Schmeck, B ^a   Opitz, B ^a   Hippenstiel, S ^a   Suttorp, N ^a   Slevogt, H ^a  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

Author keywords

Cyclooxygenase 2; Extracellular signal regulated kinase 1 2; Moraxella catarrhalis; Nuclear factor B; Prostaglandin E2; Ubiquitous cell surface protein A1

Indexed keywords

CELL SURFACE PROTEIN; CYCLOOXYGENASE 2; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE 3; OUTER MEMBRANE PROTEIN; PROSTAGLANDIN E2; MEMBRANE PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE P38; UNCLASSIFIED DRUG; USPA PROTEIN, MORAXELLA CATARRHALIS;

ARTICLE; ENZYME ACTIVATION; ENZYME LINKED IMMUNOSORBENT ASSAY; GEL MOBILITY SHIFT ASSAY; HUMAN; HUMAN CELL; LUNG ALVEOLUS EPITHELIUM; MORAXELLA CATARRHALIS; NONHUMAN; PNEUMONIA; PRIORITY JOURNAL; PROSTAGLANDIN RELEASE; PROTEIN EXPRESSION; RECEPTOR UPREGULATION; RESPIRATORY SYSTEM; CELL LINE; ENZYME INDUCTION; IMMUNOLOGY; IN VITRO STUDY; LUNG; METABOLISM; PHYSIOLOGY; RESPIRATORY TRACT MUCOSA;

BACTERIAL OUTER MEMBRANE PROTEINS; CELL LINE; CYCLOOXYGENASE 2; DINOPROSTONE; ENZYME INDUCTION; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; HUMANS; LUNG; MEMBRANE PROTEINS; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; MORAXELLA (BRANHAMELLA) CATARRHALIS; NF-KAPPA B; P38 MITOGEN-ACTIVATED PROTEIN KINASES; RESPIRATORY MUCOSA;

EID: 38449097778     PISSN: 09031936     EISSN: None     Source Type: Journal    
DOI: 10.1183/09031936.00008707     Document Type: Article

References (33)

1. Di Stefano A, Caramori G, Ricciardolo FL, Capelli A, Adcock IM, Donner CF. Cellular and molecular mechanisms in chronic obstructive pulmonary disease: an overview. Clin Exp Allergy 2004; 34: 1156-1167.
2. Murphy TF, Sethi S, Niederman MS. The role of bacteria in exacerbations of COPD. A constructive view. Chest 2000; 118: 204-209.
3. Sethi S. Pathogenesis and treatment of acute exacerbations of chronic obstructive pulmonary disease. Semin Respir Crit Care Med 2005; 26: 192-203.
4. Sethi S, Evans N, Grant BJ, Murphy TF. New strains of bacteria and exacerbations of chronic obstructive pulmonary disease. N Engl J Med 2002; 347: 465-471.
5. Murphy TF, Brauer AL, Grant BJ, Sethi S. Moraxella catarrhalis in chronic obstructive pulmonary disease: burden of disease and immune response. Am J Respir Crit Care Med 2005; 172: 195-199.
6. Chen D, McMichael JC, VanDerMeid KR, et al. Evaluation of purified UspA from Moraxella catarrhalis as a vaccine in a murine model after active immunization. Infect Immun 1996; 64: 1900-1905.
7. Hill DJ, Virji M. A novel cell-binding mechanism of Moraxella catarrhalis ubiquitous surface protein UspA: specific targeting of the N-domain of carcinoembryonic antigen-related cell adhesion molecules by UspA1. Mol Microbiol 2003; 48: 117-129.
8. Nordstrom T, Blom AM, Forsgren A, Riesbeck K. The emerging pathogen Moraxella catarrhalis interacts with complement inhibitor C4b binding protein through ubiquitous surface proteins A1 and A2. J Immunol 2004; 173: 4598-4606.
9. Tan TT, Nordstrom T, Forsgren A, Riesbeck K. The respiratory pathogen Moraxella catarrhalis adheres to epithelial cells by interacting with fibronectin through ubiquitous surface proteins A1 and A2. J Infect Dis 2005; 192: 1029-1038.
10. Tilley SL, Coffman TM, Koller BH. Mixed messages: modulation of inflammation and immune responses by prostaglandins and thromboxanes. J Clin Invest 2001; 108: 15-23.
11. Vancheri C, Mastruzzo C, Sortino MA, Crimi N. The lung as a privileged site for the beneficial actions of PGE2. Trends Immunol 2004; 25: 40-46.
12. Montuschi P, Kharitonov SA, Ciabattoni G, Barnes PJ. Exhaled leukotrienes and prostaglandins in COPD. Thorax 2003; 58: 585-588.
13. N'guessan PD, Etouem MO, Schmeck B, et al. Legionella pneumophila-induced PKCalpha-, MAPK- and NF-kappaB-dependent COX-2 expression in human lung epithelium. Am J Physiol Lung Cell Mol Physiol 2007; 292: L267-L277.
14. N'guessan PD, Hippenstiel S, Etouem MO, et al. Streptococcus pneumoniae induced p38 MAPK- and NFkappaB-dependent COX-2 expression in human lung epithelium. Am J Physiol Lung Cell Mol Physiol 2006; 290: L1131-L1138.
15. Chun KS, Surh YJ. Signal transduction pathways regulating cyclooxygenase-2 expression: potential molecular targets for chemoprevention. Biochem Pharmacol 2004; 68: 1089-1100.
16. Johnson GL, Lapadat R. Mitogen-activated protein kinase pathways mediated by ERK, JNK, and p38 protein kinases. Science 2002; 298: 1911-1912.
17. Schmeck B, N'guessan PD, Ollomang M, et al. Legionella pneumophila induced NF-κB- and MAPK-dependent cytokine release by lung epithelial cells. Eur Respir J 2007; 29: 25-33.
18. Schmeck B, Zahlten J, Moog K, et al. Streptococcus pneumoniae-induced p38 MAPK-dependent phosphorylation of RelA at the interleukin-8 promotor. J Biol Chem 2004; 279: 53241-53247.
19. Slevogt H, Schmeck B, Jonatat C, et al. Moraxella catarrhalis induces inflammatory response of bronchial epithelial cells via MAPK and NF-kappaB activation and histone deacetylase activity reduction. Am J Physiol Lung Cell Mol Physiol 2006; 290: L818-L826.
20. Rosseau S, Wiechmann K, Moderer S, et al. Moraxella catarrhalis-infected alveolar epithelium induced monocyte recruitment and oxidative burst. Am J Respir Cell Mol Biol 2005; 32: 157-166.
21. Slevogt H, Seybold J, Tiwari KN, et al. Moraxella catarrhalis is internalized in respiratory epithelial cells by a trigger-like mechanism and initiates a TLR2- and partly NOD1-dependent inflammatory immune response. Cell Microbiol 2007; 9: 694-707.
22. Slevogt H, Tiwari KN, Schmeck B, et al. Adhesion of Moraxella catarrhalis to human bronchial epithelium characterized by a novel fluorescence-based assay. Med Microbiol Immunol (Berl) 2006; 195: 73-83.
23. Ke Y, Reddel RR, Gerwin BI, et al. Human bronchial epithelial cells with integrated SV40 virus T antigen genes retain the ability to undergo squamous differentiation. Differentiation 1988; 38: 60-66.
24. N'guessan PD, Vigelahn M, Bachmann S, et al. The UspA1 protein of Moraxella catarrhalis induces CEACAM-1-dependent apoptosis in alveolar epithelial cells. J Infect Dis 2007; 195: 1651-1660.
25. Song HY, Regnier CH, Kirschning CJ, Goeddel DV, Rothe M. Tumor necrosis factor (TNF)-mediated kinase cascades: bifurcation of nuclear factor-kappaB and c-jun N-terminal kinase (JNK/SAPK) pathways at TNF receptor-associated factor 2. Proc Natl Acad Sci USA 1997; 94: 9792-9796.
26. May MJ, D'Acquisto F, Madge LA, Glockner J, Pober JS, Ghosh S. Selective inhibition of NF-kappaB activation by a peptide that blocks the interaction of NEMO with the IkappaB kinase complex. Science 2000; 289: 1550-1554.
27. Clarke DL, Belvisi MG, Smith SJ, et al. Prostanoid receptor expression by human airway smooth muscle cells and regulation of the secretion of granulocyte colony-stimulating factor. Am J Physiol Lung Cell Mol Physiol 2005; 288: L238-L250.
28. Timpe JM, Holm MM, Vanlerberg SL, Basrur V, Lafontaine ER. Identification of a Moraxella catarrhalis outer membrane protein exhibiting both adhesin and lipolytic activities. Infect Immun 2003; 71: 4341-4350.
29. Gray-Owen SD, Blumberg RS. CEACAM1: contact-dependent control of immunity. Nat Rev Immunol 2006; 6: 433-446.
30. Hwang D. Modulation of the expression of cyclooxygenase-2 by fatty acids mediated through toll-like receptor 4-derived signaling pathways. FASEB J 2001; 15: 2556-2564.
31. Gray T, Nettesheim P, Loftin C, et al. Interleukin-1beta-induced mucin production in human airway epithelium is mediated by cyclooxygenase-2, prostaglandin E2 receptors, and cyclic AMP-protein kinase A signaling. Mol Pharmacol 2004; 66: 337-346.
32. Baginski TK, Dabbagh K, Satjawatcharaphong C, Swinney DC. Cigarette smoke synergistically enhances respiratory mucin induction by proinflammatory stimuli. Am J Respir Cell Mol Biol 2006; 35: 165-174.
33. Di Stefano A, Capelli A, Donner CF. Role of interleukin-8 in the pathogenesis and treatment of COPD. Chest 2004; 126: 676-678.